Increased Tumor Necrosis Factor Superfamily Members in Neuroinflammatory Schizophrenia and Bipolar Disorder Midbrains [0.03%]
神经炎症性精神分裂症和双相情感障碍脑桥延髓中肿瘤坏死因子超家族成员的增加
Gerardo Mendez-Victoriano,Yunting Zhu,Layla Neuhaus et al.
Gerardo Mendez-Victoriano et al.
Background: Neuroinflammation is a key neuropathological finding in schizophrenia and bipolar disorder, as increased cytokines are found in the midbrain of these individuals. However, the most upregulated inflammatory cyt...
Causal Effects of Enhanced Parenting on Resting-State Graph Properties of Adolescents at Risk for Maltreatment [0.03%]
强化养育对 maltreatment 高危青少年静息态脑功能连接的影响研究
Marta Korom,Mary Dozier,Hung-Wei Bernie Chen et al.
Marta Korom et al.
Background: In this study, we investigated the sustained causal effects of enhanced early caregiving quality on adolescent brain network properties approximately 11 years after families received an attachment-based parent...
Glucagon-Like Peptide-1 Receptor Agonists and Alcohol Use: A Real-Word Observational Study in a Large, Integrated Health Care System [0.03%]
胰高血糖素样肽-1受体激动剂和饮酒行为：一项大型综合医疗体系中的真实世界观察研究
Vanessa A Palzes,Brianna Costales,Stacy Sterling et al.
Vanessa A Palzes et al.
Background: Growing research suggests that glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce alcohol consumption, positioning them as new potential pharmacotherapies for alcohol use disorder. However, human stud...
Mineralocorticoid Receptor in Glutamatergic Neurons Modulates Anxiety Exclusively in Male Mice Via Regulation of the Actin-Bundling Factor Fam107a [0.03%]
谷氨酸能神经元中的矿物质受体通过调节肌动蛋白束状因子Fam107a的方式在雄性小鼠中选择性地调节焦虑反应
Huanqing Yang,Sowmya Narayan,Joeri Bordes et al.
Huanqing Yang et al.
Background: Exposure to stressful life events is a major risk factor for many psychiatric disorders. The mineralocorticoid receptor (MR) is a key regulator of the hypothalamic-pituitary-adrenal axis, a central stress resp...
Brain State Dynamics in Ketamine-Induced Dissociation Resemble Those in Posttraumatic Stress Disorder [0.03%]
氯胺酮诱导的分离体验与 PTSD 中的大脑动态变化相似性研究
Noam Goldway,Taly Markovits,Naomi Fine et al.
Noam Goldway et al.
Background: Dissociation, an altered state of consciousness in which individuals feel detached from their body, environment, and sense of self, is a common feature of posttraumatic stress disorder (PTSD). Despite its sign...
Georgia E Hodes,Dawson R Kropp
Georgia E Hodes
Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure [0.03%]
轻度宫内酒精暴露对儿童脑和行为的长期影响
Xiangyu Long,Catherine Lebel
Xiangyu Long
Background: Heavy prenatal alcohol exposure (PAE) is associated with alterations in behavior and cognitive and brain development. However, the effects of low levels of PAE on the brain and behavior remain unclear. In the ...
Early Pubertal Development Is a Risk Factor for Psychotic-Like Experiences in Boys and Girls [0.03%]
青春期发育过早会增加男女出现精神病症状的风险
Eric R Larson,Natasha Chaku,Alexandra Moussa-Tooks
Eric R Larson
Background: Puberty has long been identified as a risk factor for psychosis, although retrospective, cross-sectional, and single-sex indicators of puberty have limited our ability to pinpoint biopsychosocial mechanisms co...