Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function [0.03%]
体外溶酶体酸性脂肪酶丧失或受抑制导致胆固醇酯堆积而不影响肌生成或线粒体功能
Alena Akhmetshina,Laszlo Schooltink,Melina Amor et al.
Alena Akhmetshina et al.
Skeletal muscle (SM) is essential for movement, stability, and overall body function, and it readily adapts to changes in energy demand. Myogenesis is energy-intensive and involves complex molecular and cellular events. We recently demonstr...
Capturing the micro-communities: Insights into biogenesis and architecture of bacterial biofilms [0.03%]
捕捉微小社区：细菌生物膜的发生学和结构的启示
Harshita Agarwal,Bharat Gurnani,Bhumika Pippal et al.
Harshita Agarwal et al.
Biofilm is an assemblage of microorganisms embedded within the extracellular matrix that provides mechanical stability, nutrient absorption, antimicrobial resistance, cell-cell interactions, and defence against host immune system. Various b...
Phosphorylation of N-glycans in the brain: The case for a non-canonical pathway? [0.03%]
脑中的N-聚糖的磷酸化：非经典通路的案例？
Lucija Sironić,Nikol Mraz,Gordan Lauc et al.
Lucija Sironić et al.
Asparagine-linked glycosylation (N-glycosylation) is a common co- and post-translational modification that refers to the addition of complex carbohydrates, called N-linked glycans (N-glycans), to asparagine residues within defined sequons o...
Valosin-containing protein (VCP), a component of tumor-derived extracellular vesicles, impairs the barrier integrity of brain microvascular endothelial cells [0.03%]
包含瓦尔奥斯因蛋白(VCP)的肿瘤源性细胞外囊泡损害脑微血管内皮细胞的屏障功能
Ramon Handerson Gomes Teles,Nicolas Jones Villarinho,Ana Sayuri Yamagata et al.
Ramon Handerson Gomes Teles et al.
Metastases are the leading cause of cancer-related deaths, and their origin is not fully elucidated. Recently, studies have shown that extracellular vesicles (EVs), particularly small extracellular vesicles (sEV), can disrupt the homeostasi...
Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays [0.03%]
单糖和聚糖的识别方法研究——利用化学感知技术和芯片型凝集素对聚糖微阵列进行分析及比较的研究
Shunsuke Tomita,Chiaki Nagai-Okatani
Shunsuke Tomita
Chemical-nose/tongue technologies are emerging as promising analytical tools for glycan analysis. After briefly introducing the importance of glycans and their analytical methods, including the lectin microarray (LMA) as one of the gold sta...
Daniel E Otzen
Daniel E Otzen
Are cellulases slow? Kinetic and thermodynamic limitations for enzymatic breakdown of cellulose [0.03%]
纤维素酶活性受限制吗？纤维素降解的酶反应动力学及热力学限制因素分析
Peter Westh,Jeppe Kari,Silke Badino et al.
Peter Westh et al.
Cellulases are of paramount interest for upcoming biorefineries that utilize residue from agriculture and forestry to produce sustainable fuels and chemicals. Specifically, cellulases are used for the conversion of recalcitrant plant biomas...
Mechano-regulation of germline development, maintenance, and differentiation [0.03%]
机械调控生殖细胞发育、维持和分化
Ishani Sharma,Anup Padmanabhan
Ishani Sharma
Biochemical signaling arising from mechanical force-induced physical changes in biological macromolecules is a critical determinant of key physiological processes across all biological lengths and time scales. Recent studies have deepened o...
MicroGlycoDB: A database of microbial glycans using Semantic Web technologies [0.03%]
MicroGlycoDB：使用语义网络技术的微生物糖类数据库
Sunmyoung Lee,Louis-David Leclercq,Yann Guerardel et al.
Sunmyoung Lee et al.
Glycoconjugates are present on microbial surfaces and play critical roles in modulating interactions with the environment and the host. Extensive research on microbial glycans, including elucidating the structural diversity of the glycan mo...
Sunada Keisham,Hiroaki Tateno
Sunada Keisham
Glycans are present on virtually all cellular surfaces and are important regulators of multicellular communications. Advances in single-cell omics technologies have revolutionized life science research by elucidating cellular heterogeneity ...