TGF-β2/OPTN/FOXC1/ miR-200 axis regulates actin dynamics in human trabecular meshwork cells [0.03%]
转化生长因子β2/OPTN/FOXC1/miR-200轴调控人小梁网细胞肌动蛋白动力学
Chenna Kesavulu Sugali,Navya Naidu Gajula,Suresh Chava et al.
Chenna Kesavulu Sugali et al.
Glaucoma is the second leading cause of irreversible blindness globally, with elevated intraocular pressure (IOP) being its primary risk factor. Current therapeutic approaches, such as beta-blockers, alpha-adrenergic agonists, Rho-kinase in...
Introduction to a special issue, "Expanded glycomics: A bridge over future glycomics" [0.03%]
专刊序言：“扩展糖组学——通向未来糖组学的桥梁”
Jun Hirabayashi,Yann Guerardel
Jun Hirabayashi
CEMIP promotes gefitinib resistance in lung cancer with EGFR-mutation possibly through forming a stable complex CEMIP/c-MYC [0.03%]
CEMIP通过形成稳定的CEMIP/c-MYC复合物可能促进EGFR突变肺癌细胞的吉非替尼耐药性
Li Li,Jiaxiu Xie,Jinxing Liang et al.
Li Li et al.
While gefitinib greatly improves the prognosis of lung cancer patients with epidermal growth factor receptor (EGFR) mutation, its inevitable resistance severely diminishes therapeutic efficacy. Cell migration-inducing protein (CEMIP) might ...
Identification of aberrant α-2,3 sialylation of cartilage associated with osteonecrosis of the femoral head based on integrated multi-omics analyses [0.03%]
基于整合多组学分析的股骨头坏死软骨异常α-2，3岩藻糖基化识别
Xueliang Lu,Xu Wang,Mingyue Xiong et al.
Xueliang Lu et al.
Purpose: Osteonecrosis of the femoral head (ONFH) is one of the most common and devastating articular cartilage diseases worldwide. The role of glycosylation in cartilage degeneration of ONFH is not yet fully understood. ...
Albumin does not induce IL-6 release and toll-like receptor activation in vitro: Role of endotoxin contamination and biochemical modifications [0.03%]
白蛋白不诱导IL-6释放和 Toll 样受体激活：内毒素污染作用及生化修饰的作用
Margret Paar,Vera H Fengler,Martina Schweiger et al.
Margret Paar et al.
Human serum albumin (HSA) is widely used in both clinical and research settings, yet its potential to stimulate immune responses remains poorly understood. In this study, we systematically investigated various therapeutic, recombinant and p...
Isonardosinone suppresses osteoclastogenesis through TRAF2/TRAF6-mediated disruption of calcium signaling and coordinate inhibition of MAPK/NF-κB pathways [0.03%]
异纳豆酚通过TRAF2/6介导的钙信号干扰及协同抑制MAPK/NF-κB通路抑制破骨细胞生成
Jielong Huang,Yang Lv,Chujie Wang et al.
Jielong Huang et al.
Background: Osteoporosis (OP), a prevalent age-related skeletal disorder, is characterized by increased osteoclast (OC) activity, leading to bone loss, reduced bone mineral density, and elevated fracture risk. Through com...
Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis [0.03%]
7-氧代-DHEA作为肺结核辅助宿主定向治疗的潜力研究
María Belén Vecchione,Jorge Barrios-Payán,Dulce Mata-Espinosa et al.
María Belén Vecchione et al.
Although anti-tuberculous therapy effectively eradicates Mycobacterium tuberculosis (Mtb) infection, it requires prolonged treatment with multiple drugs, often resulting in adverse effects and poor compliance. Therefore, novel immunotherape...
VDAC1 inhibitor DIDS uncouples respiration in isolated tissue mitochondria and induces mitochondrial hyperfusion in mammalian cells [0.03%]
VDAC1抑制剂DIDS可使分离的组织线粒体解偶联，并可使哺乳动物细胞线粒体过度融合
Surajit Das,Arpita Dutta,Minakshi Bedi et al.
Surajit Das et al.
Mitochondrial outer membrane protein, voltage-dependent anion channel 1 (VDAC1), is a gatekeeper of transport, metabolism, and cellular apoptosis. Ablation of VDAC1 or treatment with small molecular VDAC1 inhibitors often causes metabolic r...
Blending salmon gelatin with polyvinylidene fluoride using coaxial electrospinning [0.03%]
利用同轴电纺丝技术将三文鱼胶原蛋白与聚偏二氟乙烯结合在一起
Martin Chavarria-Vidal,Dragica Bezjak,Maria Saavedra-Fredes et al.
Martin Chavarria-Vidal et al.
Electrospinning is a technique that produces large quantities of nanofibers, that can be designed at the molecular level. Electrospun membranes can be designed to biomimic the chemical composition and morphological structure of the extracel...
CaF2 nanoparticles deliver siRNA targeting STAT6 and PPAR- [Formula: see text] to depolarise tumour-associated macrophages [0.03%]
CaF2 纳米颗粒递送靶向STAT6和PPAR- [Formula: see text] 的siRNA 以去极化肿瘤相关巨噬细胞
Hamed Al-Busaidi,Won Fen Wong,Lakshmi Selvaratnam et al.
Hamed Al-Busaidi et al.
Breast cancer is a leading cause of death in women, partly due to challenges posed by constituents of the tumour-microenvironment, such as tumour-associated macrophages (TAMs). Polarisation of macrophages to a pro-tumour phenotype usually i...