Identification of aberrant α-2,3 sialylation of cartilage associated with osteonecrosis of the femoral head based on integrated multi-omics analyses [0.03%]
基于整合多组学分析的股骨头坏死软骨异常α-2，3岩藻糖基化识别
Xueliang Lu,Xu Wang,Mingyue Xiong et al.
Xueliang Lu et al.
Purpose: Osteonecrosis of the femoral head (ONFH) is one of the most common and devastating articular cartilage diseases worldwide. The role of glycosylation in cartilage degeneration of ONFH is not yet fully understood. ...
Albumin does not induce IL-6 release and toll-like receptor activation in vitro: Role of endotoxin contamination and biochemical modifications [0.03%]
白蛋白不诱导IL-6释放和 Toll 样受体激活：内毒素污染作用及生化修饰的作用
Margret Paar,Vera H Fengler,Martina Schweiger et al.
Margret Paar et al.
Human serum albumin (HSA) is widely used in both clinical and research settings, yet its potential to stimulate immune responses remains poorly understood. In this study, we systematically investigated various therapeutic, recombinant and p...
Isonardosinone suppresses osteoclastogenesis through TRAF2/TRAF6-mediated disruption of calcium signaling and coordinate inhibition of MAPK/NF-κB pathways [0.03%]
异纳豆酚通过TRAF2/6介导的钙信号干扰及协同抑制MAPK/NF-κB通路抑制破骨细胞生成
Jielong Huang,Yang Lv,Chujie Wang et al.
Jielong Huang et al.
Background: Osteoporosis (OP), a prevalent age-related skeletal disorder, is characterized by increased osteoclast (OC) activity, leading to bone loss, reduced bone mineral density, and elevated fracture risk. Through com...
Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis [0.03%]
7-氧代-DHEA作为肺结核辅助宿主定向治疗的潜力研究
María Belén Vecchione,Jorge Barrios-Payán,Dulce Mata-Espinosa et al.
María Belén Vecchione et al.
Although anti-tuberculous therapy effectively eradicates Mycobacterium tuberculosis (Mtb) infection, it requires prolonged treatment with multiple drugs, often resulting in adverse effects and poor compliance. Therefore, novel immunotherape...
VDAC1 inhibitor DIDS uncouples respiration in isolated tissue mitochondria and induces mitochondrial hyperfusion in mammalian cells [0.03%]
VDAC1抑制剂DIDS可使分离的组织线粒体解偶联，并可使哺乳动物细胞线粒体过度融合
Surajit Das,Arpita Dutta,Minakshi Bedi et al.
Surajit Das et al.
Mitochondrial outer membrane protein, voltage-dependent anion channel 1 (VDAC1), is a gatekeeper of transport, metabolism, and cellular apoptosis. Ablation of VDAC1 or treatment with small molecular VDAC1 inhibitors often causes metabolic r...
Blending salmon gelatin with polyvinylidene fluoride using coaxial electrospinning [0.03%]
利用同轴电纺丝技术将三文鱼胶原蛋白与聚偏二氟乙烯结合在一起
Martin Chavarria-Vidal,Dragica Bezjak,Maria Saavedra-Fredes et al.
Martin Chavarria-Vidal et al.
Electrospinning is a technique that produces large quantities of nanofibers, that can be designed at the molecular level. Electrospun membranes can be designed to biomimic the chemical composition and morphological structure of the extracel...
CaF2 nanoparticles deliver siRNA targeting STAT6 and PPAR- [Formula: see text] to depolarise tumour-associated macrophages [0.03%]
CaF2 纳米颗粒递送靶向STAT6和PPAR- [Formula: see text] 的siRNA 以去极化肿瘤相关巨噬细胞
Hamed Al-Busaidi,Won Fen Wong,Lakshmi Selvaratnam et al.
Hamed Al-Busaidi et al.
Breast cancer is a leading cause of death in women, partly due to challenges posed by constituents of the tumour-microenvironment, such as tumour-associated macrophages (TAMs). Polarisation of macrophages to a pro-tumour phenotype usually i...
Unravelling lipid heterogeneity: Advances in single-cell lipidomics in cellular metabolism and disease [0.03%]
解开脂质异质性之谜：单细胞脂质组学在细胞代谢和疾病研究中的进展
Sutanu Sarkar,Rajgourab Ghosh
Sutanu Sarkar
Recent advancements in single-cell analysis have revolutionized our understanding of cellular heterogeneity, particularly in lipid metabolism. Single-cell lipidomics, enabled by ultra-sensitive mass spectrometry techniques such as Orbitrap ...
F-type lectins: Structural and functional aspects, and potential biomedical applications [0.03%]
F型凝集素：结构和功能及潜在的生物医学应用
Gerardo R Vasta,Mario A Bianchet
Gerardo R Vasta
Among the multiple animal lectin families recognized to date, F-type lectins (FTLs), fucose-binding lectins characterized by an FTL domain (FTLD), constitute the most recent lectin family to be identified and structurally characterized. The...
Best evidence linking the extracellular factor TGF-β to cancer-associated alternative splicing programs [0.03%]
最佳证据揭示细胞因子TGF-β与癌症相关可变剪接程序的关联
Opeoluwa Alli-Oke,Jean-Philippe Brosseau
Opeoluwa Alli-Oke
Alternative splicing is a mechanism by which several RNA transcripts can be created from one gene. Splicing factors are RNA binding proteins recognizing cis-acting sequences that positively or negatively influence the splicing decision base...