Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis [0.03%]
7-氧代-DHEA作为肺结核辅助宿主定向治疗的潜力研究
María Belén Vecchione,Jorge Barrios-Payán,Dulce Mata-Espinosa et al.
María Belén Vecchione et al.
Although anti-tuberculous therapy effectively eradicates Mycobacterium tuberculosis (Mtb) infection, it requires prolonged treatment with multiple drugs, often resulting in adverse effects and poor compliance. Therefore, novel immunotherape...
VDAC1 inhibitor DIDS uncouples respiration in isolated tissue mitochondria and induces mitochondrial hyperfusion in mammalian cells [0.03%]
VDAC1抑制剂DIDS可使分离的组织线粒体解偶联，并可使哺乳动物细胞线粒体过度融合
Surajit Das,Arpita Dutta,Minakshi Bedi et al.
Surajit Das et al.
Mitochondrial outer membrane protein, voltage-dependent anion channel 1 (VDAC1), is a gatekeeper of transport, metabolism, and cellular apoptosis. Ablation of VDAC1 or treatment with small molecular VDAC1 inhibitors often causes metabolic r...
Blending salmon gelatin with polyvinylidene fluoride using coaxial electrospinning [0.03%]
利用同轴电纺丝技术将三文鱼胶原蛋白与聚偏二氟乙烯结合在一起
Martin Chavarria-Vidal,Dragica Bezjak,Maria Saavedra-Fredes et al.
Martin Chavarria-Vidal et al.
Electrospinning is a technique that produces large quantities of nanofibers, that can be designed at the molecular level. Electrospun membranes can be designed to biomimic the chemical composition and morphological structure of the extracel...
CaF2 nanoparticles deliver siRNA targeting STAT6 and PPAR- [Formula: see text] to depolarise tumour-associated macrophages [0.03%]
CaF2 纳米颗粒递送靶向STAT6和PPAR- [Formula: see text] 的siRNA 以去极化肿瘤相关巨噬细胞
Hamed Al-Busaidi,Won Fen Wong,Lakshmi Selvaratnam et al.
Hamed Al-Busaidi et al.
Breast cancer is a leading cause of death in women, partly due to challenges posed by constituents of the tumour-microenvironment, such as tumour-associated macrophages (TAMs). Polarisation of macrophages to a pro-tumour phenotype usually i...
Unravelling lipid heterogeneity: Advances in single-cell lipidomics in cellular metabolism and disease [0.03%]
解开脂质异质性之谜：单细胞脂质组学在细胞代谢和疾病研究中的进展
Sutanu Sarkar,Rajgourab Ghosh
Sutanu Sarkar
Recent advancements in single-cell analysis have revolutionized our understanding of cellular heterogeneity, particularly in lipid metabolism. Single-cell lipidomics, enabled by ultra-sensitive mass spectrometry techniques such as Orbitrap ...
F-type lectins: Structural and functional aspects, and potential biomedical applications [0.03%]
F型凝集素：结构和功能及潜在的生物医学应用
Gerardo R Vasta,Mario A Bianchet
Gerardo R Vasta
Among the multiple animal lectin families recognized to date, F-type lectins (FTLs), fucose-binding lectins characterized by an FTL domain (FTLD), constitute the most recent lectin family to be identified and structurally characterized. The...
Best evidence linking the extracellular factor TGF-β to cancer-associated alternative splicing programs [0.03%]
最佳证据揭示细胞因子TGF-β与癌症相关可变剪接程序的关联
Opeoluwa Alli-Oke,Jean-Philippe Brosseau
Opeoluwa Alli-Oke
Alternative splicing is a mechanism by which several RNA transcripts can be created from one gene. Splicing factors are RNA binding proteins recognizing cis-acting sequences that positively or negatively influence the splicing decision base...
MALDI O-antigen glycotyping of Y. pseudotuberculosis using DAN/DHB/K matrix [0.03%]
使用DAN/DHB/K矩阵对Y. pseudotuberculosis进行MALDI O抗原糖型分析
Shogo Urakami,Hiroshi Hinou
Shogo Urakami
Yersinia pseudotuberculosis is a zoonotic gram-negative bacterium with a wide range of hosts. Twenty-one classifications of O-antigens of Y. pseudotuberculosis, including their glyco-subtypes, have been reported and used as epidemiological ...
Phosphorylation of the fission protein Drp1 contributes to the impact of the curcuminoid 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one on mitochondrial and cellular processes [0.03%]
分裂蛋白Drp1的磷酸化有助于类姜黄素1,7-二（4-羟基苯基）-1,4,6-庚三烯-3-酮对线粒体和细胞过程的影响
Navyamol Chakkalaparambil Dileep,Chi-Wei Chiu,Ching-Tse Wu et al.
Navyamol Chakkalaparambil Dileep et al.
Curcumin and its curcuminoid derivatives extracted from turmeric have been investigated for their potential therapeutic benefits in cancer treatment. Curcuminoids 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one and bisdemethoxycurcumin can ...
Vishakha Sherawat,Deepika Sharma
Vishakha Sherawat
Netrin-1, a secreted laminin-related protein, was first characterized for its pivotal role in guiding axonal growth during nervous system development. However, recent research has revealed its involvement in cancer progression and metastasi...