Inhibition of selenoprotein synthesis by Zika virus may contribute to congenital Zika syndrome and microcephaly by mimicking SELENOP knockout and the genetic disease PCCA [0.03%]
寨卡病毒通过模仿SELENOP敲除和遗传病PCCA来抑制硒蛋白合成可能是小头症和其他先天性寨卡综合征的致病原因
Gabrielle P Dailey,Lakmini S Premadasa,Jan A Ruzicka et al.
Gabrielle P Dailey et al.
Selenium status plays a major role in health impacts of various RNA viruses. We previously reported potential antisense interactions between viral mRNAs and host mRNAs encoding isoforms of the antioxidant selenoprotein thioredoxin reductase...
A native cell membrane nanoparticles system allows for high-quality functional proteoliposome reconstitution [0.03%]
一种天然细胞膜纳米颗粒系统能够实现高质量的功能性蛋白脂质体重构
Limin Yang,Claudio Catalano,Yunyao Xu et al.
Limin Yang et al.
Proteoliposomes mimic the cell membrane environment allowing for structural and functional membrane protein analyses as well as antigen presenting and drug delivery devices. To make proteoliposomes, purified functional membrane proteins are...
Changes in neurodegeneration-related miRNAs in brains from CAPN1-/- mice [0.03%]
CAPN1基因敲除小鼠脑内与神经退行性疾病有关的miRNA的变化
Wenyue Su,Xiaoning Bi,Yubin Wang et al.
Wenyue Su et al.
Calpain-1 knock-out (KO) mice exhibit enhanced susceptibility to neurodegeneration due to the lack of the neuroprotective function of calpain-1. Dicer has been shown to play a fundamental role in the biogenesis of most miRNAs. Here, we iden...
Asymmetric dynamics of dimeric SARS-CoV-2 and SARS-CoV main proteases in an apo form: Molecular dynamics study on fluctuations of active site, catalytic dyad, and hydration water [0.03%]
二聚化SARS-CoV-2和SARS-CoV主要蛋白酶空形式的非对称动力学：关于活性位点、催化二元体以及水合水波动的分子动力学研究
Shinji Iida,Yoshifumi Fukunishi
Shinji Iida
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world. It is necessary to examine the viral proteins that play a notorious role in the invasion of our body. The main protease (3CLpro) facilitat...