Probucol treatment is associated with an ABCA1-independent mechanism of cholesterol efflux to lipid poor apolipoproteins from foam cell macrophages [0.03%]
Probucol治疗与泡沫细胞巨噬细胞向脂质贫乏的载脂蛋白胆固醇流出的ABCA1非依赖性机制有关
Anouar Hafiane,Alessandro Pisaturo,Annalisa Ronca et al.
Anouar Hafiane et al.
Objective: Probucol is a cholesterol-lowering agent whose ability to prevent atherosclerosis is currently under study. Herein, we investigate the putative mechanism of probucol by observation of changes in cellular choles...
The 1.3-Å resolution structure of bovine cytochrome c oxidase suggests a dimerization mechanism [0.03%]
牛细胞色素c氧化酶的1.3埃分辨率结构暗示了其二聚机制
Kyoko Shinzawa-Itoh,Miki Hatanaka,Kazuya Fujita et al.
Kyoko Shinzawa-Itoh et al.
Cytochrome c oxidase (CcO) in the respiratory chain catalyzes oxygen reduction by coupling electron and proton transfer through the enzyme and proton pumping across the membrane. Although the functional unit of CcO is monomeric, mitochondri...
Urinary exosome proteomic profiling defines stage-specific rapid progression of autosomal dominant polycystic kidney disease and tolvaptan efficacy [0.03%]
尿液外泌体蛋白组学谱型可定义常染色体显性遗传多囊肾病的分期特异性快速进展及托伐普坦有效性的评估
Katie L Raby,Harry Horsely,Aidan McCarthy-Boxer et al.
Katie L Raby et al.
ADPKD is the most common genetic disease of the kidney leading to end-stage renal disease necessitating renal replacement therapy at any time between the 1st and 8th decades of life due to widely variable rates of disease progression. This ...
The degree and position of phosphorylation determine the impact of toxic and trace metals on phosphoinositide containing model membranes [0.03%]
磷酸化程度和位置决定了有毒及痕量金属对磷脂酰肌醇类囊泡的影响
Weiam Daear,Robyn Mundle,Kevin Sule et al.
Weiam Daear et al.
This work assessed effects of metal binding on membrane fluidity, liposome size, and lateral organization in biomimetic membranes composed of 1 mol% of selected phosphorylated phosphoinositides in each system. Representative examples of pho...
Effects of CpG methylation on the thermal stability of c-kit 2, c-kit*, and c-kit 1 G-quadruplex structures [0.03%]
CpG甲基化对c-kit 2、c-kit*和c-kit 1四链体热稳定性的影响
Saowalak Laddachote,Rika Ishii,Wataru Yoshida
Saowalak Laddachote
In genomic DNA, G-quadruplex (G4)-forming DNA can form either a duplex or G4 structure, suggesting that understanding the factors regulating G4 formation is important for revealing the cellular functions controlled by G4 formation. Cytosine...
Effect of quercetin on lipid membrane rigidity: assessment by atomic force microscopy and molecular dynamics simulations [0.03%]
槲皮素对脂质膜刚性的影响：基于原子力显微镜和分子动力学模拟的评估
Jad Eid,Alia Jraij,Hélène Greige-Gerges et al.
Jad Eid et al.
Quercetin (3,3',4',5,7-pentahydroxyl-flavone) is a natural flavonoid with many valuable biological effects, but its solubility in water is low, posing major limitations in applications. Quercetin encapsulation in liposomes increases its bio...
Cannabinoids accumulate in mouse breast milk and differentially regulate lipid composition and lipid signaling molecules involved in infant development [0.03%]
大麻类物质在小鼠乳汁中堆积并差异调节参与婴儿发育的脂质成分和脂质信号分子
Clare T Johnson,Gabriel H Dias de Abreu,Ken Mackie et al.
Clare T Johnson et al.
Maternal cannabis use during lactation may expose developing infants to cannabinoids (CBs) such as Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBs modulate lipid signaling molecules in the central nervous system in age- and cell-...
Fragments of Locusta migratoria apoLp-III provide insight into lipid binding [0.03%]
家蚕鹰尾病毒apoLp-III片段提供脂质结合的见解
Blair A Russell,James V C Horn,Paul M M Weers
Blair A Russell
Apolipophorin III (apoLp-III) from Locusta migratoria is an exchangeable apolipoprotein with a critical role in lipid transport in insects. The protein is composed of a bundle of five amphipathic α-helices which undergo a large conformatio...
Analysis of the assembly pathway for membrane subunits of Complex I reveals that subunit L (ND5) can assemble last in E. coli [0.03%]
分析复合物I膜亚基组装途径 发现亚基L（ND5）在大肠杆菌中最后完成组装
Fang Zhang,Steven B Vik
Fang Zhang
Respiratory Complex I, a multi-subunit, membrane-bound enzyme, oxidizes NADH in the electron transport chains of mammalian mitochondria, and many bacterial species. We have examined in vivo assembly of the membrane subunits of Complex I fro...
The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia [0.03%]
冠状病毒受体血管紧张素转化酶2(ACE2)在不同气道上皮细胞中的动态表达特点
Vincent J Manna,Hana Choi,Shawna M Rotoli et al.
Vincent J Manna et al.
Once inhaled, SARS-CoV-2 particles enter respiratory ciliated cells by interacting with angiotensin converting enzyme 2 (ACE2). Understanding the nature of ACE2 within airway tissue has become a recent focus particularly in light of the COV...