The antimicrobial peptide Polybia-MP1 differentiates membranes with the hopanoid, diplopterol from those with cholesterol [0.03%]
区分含有二戊烯三醇和胆固醇的细胞膜的抗微生物肽Polybia-MP1
Dayane S Alvares,Mariela R Monti,João Ruggiero Neto et al.
Dayane S Alvares et al.
Polybia-MP1 is an antimicrobial peptide that shows a decreased activity in membranes with cholesterol (CHO). Since it is now accepted that hopanoids act as sterol-surrogates in some sterol-lacking bacteria, we here inquire about the impact ...
Membrane dynamics are slowed for Alexa594-labeled membrane proteins due to substrate interactions [0.03%]
底物相互作用导致标记膜蛋白的荧光动力学变慢
Alan W Weisgerber,Michelle K Knowles
Alan W Weisgerber
The addition of fluorescent dyes to proteins, lipids and other biological molecules can affect a range of processes such as mobility, molecular interactions, localization, and, ultimately, function. The dynamics of a protein can be dramatic...
Role of the Connexin C-terminus in skin pattern formation of Zebrafish [0.03%]
斑马鱼皮肤色素细胞形态发生中连接蛋白C端的作用机制研究
Yuu Usui,Masakatsu Watanabe
Yuu Usui
Background: Zebrafish display a striped skin pattern on their body; two types of connexins, namely, Connexin39.4 (Cx39.4) and Connexin41.8 (Cx41.8), are involved in stripe pattern formation. Herein, we investigated the ro...
A theoretical perspective of the physical properties of different RNA modifications with respect to RNA duplexes [0.03%]
不同RNA修饰物的物理性质的理论研究——与RNA双链体的关系
Norman H L Chiu,Jennifer H Simpson,Hongzhou Wang et al.
Norman H L Chiu et al.
Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers. Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modificatio...
Identification and characterization of the Hfq bacterial amyloid region DNA interactions [0.03%]
Hfq细菌淀粉样区域DNA相互作用的鉴定与表征
Florian Turbant,Omar El Hamoui,David Partouche et al.
Florian Turbant et al.
Nucleic acid amyloid proteins interactions have been observed in the past few years. These interactions often promote protein aggregation. Nevertheless, molecular basis and physiological consequences of these interactions are still poorly u...
Narciclasine is a novel YAP inhibitor that disturbs interaction between YAP and TEAD4 [0.03%]
纳鲁克拉斯林是一种新型的YAP抑制剂可干扰YAP与TEAD4之间的相互作用
Rie Kawamoto,Naoko Nakano,Haruka Ishikawa et al.
Rie Kawamoto et al.
Yes-associated protein (YAP) is involved in development, cell growth, cell size, and homeostasis and plays a key role in the progression of various cancers. Among them, constitutive activation of YAP can often be observed in malignant mesot...
Hao-Li Huang,Gary W Brudvig
Hao-Li Huang
We derive a model that provides an exact solution to the substrate-water exchange kinetics in a double-conformation system and use this model to interpret recently published data for Ca2+- and Sr2+-containing PSII in the S2 state, in which ...
Epigenetic modulation of selected immune response genes and altered functions of T lymphocytes and macrophages collectively contribute to autoimmune diabetes protection [0.03%]
表观遗传调控选择性免疫反应基因及T淋巴细胞和巨噬细胞功能的改变协同促进自身免疫糖尿病保护效应
Arathi Jayaraman,Maria Arianas,Sundararajan Jayaraman
Arathi Jayaraman
We have previously demonstrated that weekly treatment of female prediabetic NOD mice with a low dose of the histone deacetylase inhibitor Trichostatin A (TSA) bestowed long-lasting, irreversible protection against autoimmune diabetes. Herei...
Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2 [0.03%]
SLC6神经递质转运蛋白的脂质指纹研究：dDAT、hDAT、hSERT和GlyT2的比较分析
Katie A Wilson,Lily Wang,Yie Chang Lin et al.
Katie A Wilson et al.
The local lipid annulus, or "fingerprint", of four SLC6 transporters (dDAT, hDAT, hSERT, and GlyT2) embedded in a complex neuronal membrane were compared and characterised using molecular dynamics. Our analysis included the development of n...
Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features [0.03%]
细菌中蛋白磷酸酶(PPP)序列家族的起源：祖先序列变化、辐射模式及底物结合特性
David Kerk,Mario E Valdés-Tresanco,Ryan Toth et al.
David Kerk et al.
Background: Phosphoprotein phosphatases (PPP) belong to the PPP Sequence family, which in turn belongs to the broader metallophosphoesterase (MPE) superfamily. The relationship between the PPP Sequence family and other me...