Homeostasis of carbohydrates and reactive oxygen species is critically changed in the brain of middle-aged mice: Molecular mechanisms and functional reasons [0.03%]
小鼠脑内碳水化合物和活性氧的稳态在中年时发生 critical 改变：分子机制和功能原因
Maria M Bayliak,Dmytro V Gospodaryov,Volodymyr I Lushchak
Maria M Bayliak
The brain is an organ that consumes a lot of energy. In the brain, energy is required for synaptic transmission, numerous biosynthetic processes and axonal transport in neurons, and for many supportive functions of glial cells. The main sou...
Automated image analysis method to detect and quantify fat cell infiltration in hematoxylin and eosin stained human pancreas histology images [0.03%]
一种检测和量化胰腺组织学图像中脂肪细胞浸润的自动化图像分析方法
Roshan Ratnakar Naik,Annie Rajan,Nehal Kalita
Roshan Ratnakar Naik
Fatty infiltration in pancreas leading to steatosis is a major risk factor in pancreas transplantation. Hematoxylin and eosin (H and E) is one of the common histological staining techniques that provides information on the tissue cytoarchit...
DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation [0.03%]
秀丽隐杆线虫中的DOT-1.1(DOT1L) 缺陷导致基因激活依赖于小分子RNA
Thomas Liontis,Karisma Verma,Alla Grishok
Thomas Liontis
Methylation of histone H3 at lysine 79 (H3K79) is conserved from yeast to humans and is accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C. elegans enzyme DOT-1.1 and its interacting partners are similar to ...
Metabolic engineering of non-conventional yeasts for construction of the advanced producers of biofuels and high-value chemicals [0.03%]
非传统酵母的代谢工程构建先进生物燃料和高附加值化学品生产菌株
Andriy A Sibirny
Andriy A Sibirny
Non-conventional yeasts, i.e. yeasts different from Saccharomyces cerevisiae, represent heterogenous group of unicellular fungi consisting of near 1500 species. Some of these species have interesting and sometimes unique properties like abi...
Modeling of Ca2+ transients initiated by GPCR agonists in mesenchymal stromal cells [0.03%]
由G蛋白偶联受体激动剂诱导的间质干细胞内钙瞬变的动力学模拟研究
Nikolai P Kaimachnikov,Polina D Kotova,Ekaterina N Kochkina et al.
Nikolai P Kaimachnikov et al.
The integrative study that included experimentation and mathematical modeling was carried out to analyze dynamic aspects of transient Ca2+ signaling induced by brief pulses of GPCR agonists in mesenchymal stromal cells from the human adipos...
The balance of concentration between Prokineticin 2β and Prokineticin 2 modulates the food intake by STAT3 signaling [0.03%]
Prokineticin 2β和Prokineticin 2通过STAT3信号转导调控摄食的平衡关系
Daniela Maftei,Roberta Lattanzi,Martina Vincenzi et al.
Daniela Maftei et al.
The secreted bioactive peptide prokineticin 2 (PK2) is a potent adipokine and its central and peripheral administration reduces food intake in rodents. The pk2 gene has two splice variants, PK2 and PK2L (PK2 long form), which is cleaved int...
Leading individual features of antioxidant systematically classified by the ORAC assay and its single electron transfer and hydrogen atom transfer reactivities; analyzing ALS therapeutic drug Edaravone [0.03%]
采用ORAC法对抗氧化剂进行系统分类及其单电子转移和氢原子转移活性分析；ALS治疗药物edaravone的个体特征研究
Miwa Takatsuka,Satoru Goto,Kenshiro Kobayashi et al.
Miwa Takatsuka et al.
Many natural compounds mop up radicals and limit radical reactions and may prove useful in reducing or preventing oxidative stress-related diseases in vivo. Several assays have been developed to measure antioxidant or anti-radical activity....
Quantitative assessment of chlorophyll types in cryo-EM maps of photosystem I acclimated to far-red light [0.03%]
远红光适应型光系统I的叶绿素种类的定量分析
Christopher J Gisriel,Hao-Li Huang,Krystle M Reiss et al.
Christopher J Gisriel et al.
Chlorophyll cofactors are vital for the metabolism of photosynthetic organisms. Cryo-electron microscopy (cryo-EM) has been used to elucidate molecular structures of pigment-protein complexes, but the minor structural differences between mu...
Kinetic analysis of antibody binding to integral membrane proteins stabilized in SMALPs [0.03%]
抗体结合SMALP稳定后的整合型膜蛋白的动力学分析
Pooja Sharma,Matthew Plant,Sheung Kwan Lam et al.
Pooja Sharma et al.
The fundamental importance of membrane protein (MP) targets in central biological and cellular events has driven a marked increase in the use of membrane mimetics for exploring these proteins as therapeutic targets. The main challenge assoc...
Lipid and protein dynamics of stacked and cation-depletion induced unstacked thylakoid membranes [0.03%]
垛叠和缺钾诱导的非垛叠类囊体膜的脂质和蛋白动力学研究
Faezeh Nami,Lijin Tian,Martina Huber et al.
Faezeh Nami et al.
Chloroplast thylakoid membranes in plants and green algae form 3D architectures of stacked granal membranes interconnected by unstacked stroma lamellae. They undergo dynamic structural changes as a response to changing light conditions that...