Membrane interactions of apoptotic inhibitor Bcl-xL: What can be learned using fluorescence spectroscopy [0.03%]
荧光光谱技术揭秘凋亡抑制蛋白Bcl-xL与膜的相互作用
Alexander Kyrychenko,Alexey S Ladokhin
Alexander Kyrychenko
Permeabilization of the mitochondrial outer membrane-a point of no return in apoptotic regulation-is tightly controlled by proteins of the Bcl-2 family. Apoptotic inhibitor Bcl-xL is an important member of this family, responsible for block...
Leonid Gorb,Oleg V Shishkin,Tetiana Zubatiuk
Leonid Gorb
In this review, we analyze and systematize our computational studies of the nucleic acid duplex formations and thermodynamic stability under the different factors of investigation. The proposed structural models of mini-helix contains N nuc...
Functional properties of individual sub-domains of the fibrin(ogen) αC-domains [0.03%]
纤维蛋白(原)αC区个别亚结构域的功能性质
Y M Stohnii,T A Yatsenko,V V Nikulina et al.
Y M Stohnii et al.
Background: Fibrinogen is a large polyfunctional plasma protein consisting of a number of structural and functional domains. Among them, two αC-domains, each formed by the amino acid residues Аα392-610, are involved in...
Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology [0.03%]
理性设计的分子印迹聚合物膜在分析生物技术中作为抗体和酶模仿物的应用研究
Tetyana Sergeyeva,Olena Piletska,Sergiy Piletsky
Tetyana Sergeyeva
The paper is a self-review of works on development of new approaches to formation of mimics of receptor and catalytic sites of biological macromolecules in the structure of highly cross-linked polymer membranes and thin films. The general s...
Neuropathic pain changes the output of rat lamina I spino-parabrachial neurons [0.03%]
神经病理性疼痛改变大鼠脊髓背盖层I神经元的输出信号
Volodymyr Krotov,Kirill Agashkov,Sergii Romanenko et al.
Volodymyr Krotov et al.
• Spared nerve injury (SNI) altered the action potential (AP) output of lamina I spino-parabrachial neurons (SPNs) without affecting their resting potential or membrane resistance. • In one-third of SPNs, high-threshold dorsal root stimul...
Modulation of the IKS channel by PIP2 requires two binding sites per monomer [0.03%]
PIP2调节IKS通道需要每个亚基结合两个配体分子
Audrey Deyawe Kongmeneck,Marina A Kasimova,Mounir Tarek
Audrey Deyawe Kongmeneck
The phosphatidyl-inositol-4,5-bisphosphate (PIP2) lipid has been shown to be crucial for the coupling between the voltage sensor and the pore of the potassium voltage-gated KV7 channel family, especially the KV7.1 channel. Expressed in the ...
Temperature-dependent contractility of rat tunica dartos muscle: Contribution of cold, menthol-sensitive TRPM8 [0.03%]
大鼠提睾肌收缩的温度依赖性：冷和薄荷醇敏感的TRPM8通道的贡献
Igor B Philyppov,Ganna V Sotkis,Bizhan R Sharopov et al.
Igor B Philyppov et al.
Tunica dartos smooth muscle (TDSM) lies beneath the scrotal skin, and its contraction leads to scrotum wrinkling upon cooling. However, neither the nature of TDSM cold-sensitivity nor the underlying molecular sensors are well understood. He...
Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A [0.03%]
蛋白质相互作用的发现及辅酶A抗氧化功能的特征分析
Valeriy Filonenko,Ivan Gout
Valeriy Filonenko
Coenzyme A (CoA) is an essential cofactor in all living cells which plays critical role in cellular metabolism, the regulation of gene expression and the biosynthesis of major cellular constituents. Recently, CoA was found to function as a ...
Fibril elongation by human islet amyloid polypeptide is the main event linking aggregation to membrane damage [0.03%]
人胰岛淀粉样多肽纤维伸长是连接聚集物与膜损伤的主要事件
Barend O W Elenbaas,Stefanie M Kremsreiter,Lucie Khemtemourian et al.
Barend O W Elenbaas et al.
The aggregation of human islet amyloid polypeptide (hIAPP) is linked to the death of pancreatic β-cells in type II diabetes. The process of fibril formation by hIAPP is thought to cause membrane damage, but the precise mechanisms are still...
Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis [0.03%]
鉴定出调控ELOVL6和胶质母细胞瘤肿瘤发生的关键微小RNA
Nurani Istiqamah,Takashi Matsuzaka,Momo Shimizu et al.
Nurani Istiqamah et al.
ELOVL fatty acid elongase 6 (ELOVL6) controls cellular fatty acid (FA) composition by catalyzing the elongation of palmitate (C16:0) to stearate (C18:0) and palmitoleate (C16:1n-7) to vaccinate (C18:1n-7). Although the transcriptional regul...