Comparative study of the hydrophobic interaction effect of pH and ionic strength on aggregation/emulsification of Congo red and amyloid fibrillation of insulin [0.03%]
pH和离子强度对刚果红缔合/增溶及胰岛素淀粉样纤维化影响的比较研究
Takahiro Kasai,Takashi Wada,Tsubasa Iijima et al.
Takahiro Kasai et al.
Amyloid fibrillation is provoked by the conformational rearrangement of its source. In our previous study, we claimed that the conformational rearrangement of hen egg white lysozyme requires intermolecular aggregation/packing induced. Our p...
Ameliorative effect of fluvoxamine against colon carcinogenesis via COX-2 blockade with oxidative and metabolic stress reduction at the cellular, molecular and metabolic levels [0.03%]
氟伏沙明通过在细胞、分子和代谢水平上抑制COX-2减少氧化和代谢压力来改善结肠癌变的积极作用
Pranesh Kumar,Mohit Kumar,Anurag Kumar Gautam et al.
Pranesh Kumar et al.
Fluvoxamine's (FLX's) anticancer potential was investigated in pre-clinical research utilizing a DMH-induced colorectal cancer (CRC) rat model. qRT-PCR and immunoblotting validated the mechanistic investigation. The CRC condition was induce...
Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin [0.03%]
人黑色素细胞中细菌脂多糖种属和血清型依赖性的效应-轻度和深色肤色皮肤中的作用
Shilpi Goenka
Shilpi Goenka
Lipopolysaccharides (LPS) alter melanin synthesis and induce cytokine secretion in melanocytes; however, effects of different serotypes or species of LPS have been rarely addressed. Herein, LPS from serotypes (O55:B5, O26:B6, O128:B12) of E...
Characterization of the MYB-inhibitory potential of the Pan-HDAC inhibitor LAQ824 [0.03%]
LAQ824的泛组蛋白去乙酰酶抑制活性及其对MYB转录活化的抑制作用
Maria V Yusenko,Karl-Heinz Klempnauer
Maria V Yusenko
A large body of work has shown that MYB acts as a master transcription regulator in hematopoietic cells and has pinpointed MYB as a potential drug target for acute myeloid leukemia (AML). Here, we have examined the MYB-inhibitory potential ...
Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses [0.03%]
HexM磷酸化增强改善溶酶体摄取及治疗GM2神经鞘脂病的潜能
Graeme Benzie,Kristen Bouma,Taylor Battellino et al.
Graeme Benzie et al.
Tay-Sachs and Sandhoff diseases are genetic disorders resulting from mutations in HEXA or HEXB, which code for the α- and β-subunits of the heterodimer β-hexosaminidase A (HexA), respectively. Loss of HexA activity results in the accumul...
Universal nature of cholinergic regulation demonstrated with nicotinic acetylcholine receptors [0.03%]
胆碱能调节的普遍性：用烟碱型乙酰胆碱受体证明的例子
Maryna Skok
Maryna Skok
Mammalian nicotinic acetylcholine receptors (nAChRs) were initially discovered as ligand-gated ion channels mediating fast synaptic transmission in the neuro-muscular junctions and autonomic ganglia. They were further found to be involved i...
Mapping glycation and glycoxidation sites in collagen I of human cortical bone [0.03%]
人类皮质骨中I型胶原糖基化和糖氧化位点的图谱测绘
Paul Voziyan,Sasidhar Uppuganti,Micheal Leser et al.
Paul Voziyan et al.
Accumulation of advanced glycation end products (AGEs), particularly in long-lived extracellular matrix proteins, has been implicated in pathogenesis of diabetic complications and in aging. Knowledge about specific locations of AGEs and the...
Biophysical analysis of Gaussia luciferase bioluminescence mechanisms using a non-oxidizable coelenterazine [0.03%]
利用非氧化型腔肠素进行Gaussia萤光素酶生物发光机制的生物物理分析
Kyoko Takatsu,Naohiro Kobayashi,Nan Wu et al.
Kyoko Takatsu et al.
Gaussia luciferase (GLuc 18.2kDa; 168 residues) is a marine copepod luciferase that emits a bright blue light when oxidizing coelenterazine (CTZ). It is a helical protein where two homologous sequential repeats form two anti-parallel bundle...
B S Negrutskii,V F Shalak,O V Novosylna et al.
B S Negrutskii et al.
The eEF1 family of mammalian translation elongation factors is comprised of the two variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of eEF1Bα, eEF1Bβ, and eEF1Bγ subunits. The two eEF1A variants have sim...
Translation factor accelerating peptide bond formation on the ribosome: EF-P and eIF5A as entropic catalysts and a potential drug targets [0.03%]
加速核糖体上肽键形成的翻译因子：作为熵催化剂的EF-P和eIF5A以及潜在的药物靶点
Vitalii Mudryi,Frank Peske,Marina Rodnina
Vitalii Mudryi
Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary translation factors that facilitate peptide bond formation when several sequential proline (Pro) residues are incorporated into the nascent chain. EF-P and eIF5A bind...