APP deficiency and HTRA2 modulates PrPc proteostasis in human cancer cells [0.03%]
APP缺乏和HTRA2调节人类癌细胞中PrPc稳态
Denis S F Biard,Rafika Jarray,Nicolas Rebergue et al.
Denis S F Biard et al.
Cellular protein homeostasis (proteostasis) requires an accurate balance between protein biosynthesis, folding, and degradation, and its instability is causally related to human diseases and cancers. Here, we created numerous engineered can...
A global analysis on the differential regulation of RNA binding proteins (RBPs) by TNF-α as potential modulators of metabolic syndromes [0.03%]
对RNA结合蛋白(RBPs)的差异调控进行全球分析以寻找可能影响代谢综合征的因素及机制-TNF-α的作用及相关研究
Jiss Maria Louis,Arjun Agarwal,Sukanta Mondal et al.
Jiss Maria Louis et al.
Metabolic syndrome (MetS) is associated with a group of conditions, which enhances the risk of diabetes, heart diseases and stroke in the affected individuals. Earlier reports from our lab have shown that Tumor necrosis factor-α (TNF-α) s...
Structural insights into blue-green light utilization by marine green algal light harvesting complex II at 2.78 Å [0.03%]
来自海洋绿藻光捕获复合体II的蓝色和绿色光利用机理的结构透视图（2.78Å）
Soichiro Seki,Tetsuko Nakaniwa,Pablo Castro-Hartmann et al.
Soichiro Seki et al.
Light-harvesting complex II (LHCII) present in plants and green algae absorbs solar energy to promote photochemical reactions. A marine green macroalga, Codium fragile, exhibits the unique characteristic of absorbing blue-green light from t...
DENSS-multiple: A structure reconstruction method using contrast variation of small-angle neutron scattering based on the DENSS algorithm [0.03%]
基于DENSS算法的对比变化小角中子散射结构重构方法(DENSS-多重)
Jacob Sumner,Shuo Qian
Jacob Sumner
The 3D structure of biomacromolecules, such as protein and DNA/RNA, provide keys to understanding their biological functions. Among many structural biology techniques, small-angle scattering techniques with ab initio methods have been widel...
Influenza A virus hemagglutinin prevents extensive membrane damage upon dehydration [0.03%]
流感A病毒血凝素在脱水时防止膜损伤过度扩大
Maiara A Iriarte-Alonso,Alexander M Bittner,Salvatore Chiantia
Maiara A Iriarte-Alonso
While the molecular mechanisms of virus infectivity are rather well known, the detailed consequences of environmental factors on virus biophysical properties are poorly understood. Seasonal influenza outbreaks are usually connected to the l...
Role of lipopolysaccharide in antimicrobial and cell penetrating peptide membrane interactions probed by deuterium NMR of whole cells [0.03%]
用于探究脂多糖在抗菌及细胞穿膜肽膜相互作用中所起的作用的全细菌氘核磁共振研究
Sarika Kumari,Michael R Morrow,Valerie Booth
Sarika Kumari
Understanding how non-lipid components of bacteria affect antimicrobial peptide (AMP)-induced membrane disruption is important for a comprehensive understanding of AMP mechanisms and informing AMP-based drug development. This study investig...
Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation [0.03%]
膜囊泡与假单胞菌功能淀粉样蛋白FapC的相互作用促进了淀粉样纤维的形成
Zahra Najarzadeh,Hossein Mohammad-Beigi,Jannik Nedergaard Pedersen et al.
Zahra Najarzadeh et al.
Functional amyloids (FA) are proteins which are evolutionarily optimized to form highly stable fibrillar structures that strengthen the bacterial biofilm matrix. FA such as CsgA (E. coli) and FapC (Pseudomonas) are secreted to the bacterial...
Structural diversity, bioactivity, and biosynthesis of phosphoglycolipid family antibiotics: Recent advances [0.03%]
磷糖脂类抗生素的结构多样性、生物活性及生物合成研究进展
Bohdan Ostash,Roman Makitrynskyy,Oleksandr Yushchuk et al.
Bohdan Ostash et al.
Moenomycins, such as moenomycin A, are phosphoglycolipid specialized metabolites produced by a number of actinobacterial species. They are among the most potent antibacterial compounds known to date, which drew numerous studies directed at ...
Fascin-1: Updated biological functions and therapeutic implications in cancer biology [0.03%]
Fascin-1：癌生物学中的更新生物学功能和治疗意义
Chien-Hsiu Li,Ming-Hsien Chan,Shu-Mei Liang et al.
Chien-Hsiu Li et al.
Filopodia are cellular protrusions that respond to a variety of stimuli. Filopodia are formed when actin is bound to the protein Fascin, which may play a crucial role in cellular interactions and motility during cancer metastasis. Significa...
Fӧrster resonance energy transfer analysis of amyloid state of proteins [0.03%]
福斯特共振能量转移在蛋白质淀粉样状态中的分析研究
Valeriya Trusova,Uliana Tarabara,Olga Zhytniakivska et al.
Valeriya Trusova et al.
The Förster resonance energy transfer (FRET) is a well-established and versatile spectroscopic technique extensively used for exploring a variety of biomolecular interactions and processes. The present review is intended to cover the main ...