Myeloid-derived suppressor cells promote the formation of abdominal aortic aneurysms through the IL-3-ICOSL-ICOS axis [0.03%]
髓系抑制细胞通过IL-3-ICOSL-ICOS轴促进腹主动脉瘤的形成
Li Lu,Yi Jin,Yuanhao Tong et al.
Li Lu et al.
Th17 cells are powerful inflammation promoters in the pathogenesis of abdominal aortic aneurysms (AAAs). Myeloid-derived suppressor cells (MDSCs) can promote the differentiation of Th17 cells in chronic inflammatory autoimmune injury. Here,...
Natamycin interferes with ergosterol-dependent lipid phases in model membranes [0.03%]
那他霉素干扰模型膜中的麦角固醇依赖性脂质相态
Vibeke Akkerman,Holger A Scheidt,Peter Reinholdt et al.
Vibeke Akkerman et al.
Natamycin is an antifungal polyene macrolide that is used as a food preservative but also to treat fungal keratitis and other yeast infections. In contrast to other polyene antimycotics, natamycin does not form ion pores in the plasma membr...
Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail [0.03%]
基于分子动力学的药物膜通透性原子级研究进展
André M M Gomes,Paulo J Costa,Miguel Machuqueiro
André M M Gomes
Several factors affect the passive membrane permeation of small molecules, including size, charge, pH, or the presence of specific chemical groups. Understanding these features is paramount to identifying or designing drug candidates with o...
Advances in chaperone-assisted RNA crystallography using synthetic antibodies [0.03%]
利用合成抗体在分子伴侣辅助RNA晶体学研究中的进展
Hasan Al Banna,Naba Krishna Das,Manju Ojha et al.
Hasan Al Banna et al.
RNA molecules play essential roles in many biological functions, from gene expression regulation, cellular growth, and metabolism to catalysis. They frequently fold into three-dimensional structures to perform their functions. Therefore, de...
Characterization of two bacterial multi-flavinylated proteins harboring multiple covalent flavin cofactors [0.03%]
两个含有多种共价黄素辅因子的细菌多黄素蛋白的特性分析
Yapei Tong,Henriette J Rozeboom,Marnix R Loonstra et al.
Yapei Tong et al.
In recent years, studies have shown that a large number of bacteria secrete multi-flavinylated proteins. The exact roles and properties, of these extracellular flavoproteins that contain multiple covalently anchored FMN cofactors, are still...
Cyclic voltammetry, square wave voltammetry or electrochemical impedance spectroscopy? Interrogating electrochemical approaches for the determination of electron transfer rates of immobilized redox proteins [0.03%]
线性伏安法，平方波伏安法还是电化学阻抗谱？询问电化学方法以确定固定化氧化还原蛋白质的电子转移速率
F H Pilz,P Kielb
F H Pilz
In this article, we cross-examine three well-established electrochemical approaches, namely cyclic voltammetry (CV), cyclic square-wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS) to dissect the electron transfer (ET)...
Harry G Gannon,Martin J Cann
Harry G Gannon
Background Identifying CO2-binding proteins is vital for our knowledge of CO2-regulated molecular processes. The carbamate post-translational modification is a reversible CO2-mediated adduct that can form on neutral N-terminal α-amino or l...
Oleg Krishtal
Oleg Krishtal
The author recalls several particularly memorable events during his scientific career that led to the discovery of acid-sensing ion channels and ionotropic purinergic receptors. The readers learn of the events of 1975 when the first intrace...
Insight into the self-assembly and gel formation of a bioactive peptide derived from bovine casein [0.03%]
来源于牛酪蛋白的生物活性肽自组装及凝胶化研究进展
Noémie Petit,Jolon M Dyer,Juliet A Gerrard et al.
Noémie Petit et al.
Abstract: The self-assembling and gelation properties of a bioactive peptide derived from bovine casein (FFVAPFPEVFGK) were studied in the peptide's natural form (uncapped, uncapFFV) and capped with protecting groups adde...
Proton transfer reactions: From photochemistry to biochemistry and bioenergetics [0.03%]
质子转移反应：从光化学到生物化学和生物能学
Alexander P Demchenko
Alexander P Demchenko
The present Review is an attempt by projecting the basic knowledge on photochemical proton transfer to achieve consistent understanding of proton motions in biocatalysis, photobiocatalysis, operation of selective proton channels and systems...