Drying parameters and aging modulate protective properties of vitrified trehalose [0.03%]
干燥参数和老化调节了玻璃态海藻糖的保护作用属性
U G V S S Kumara,Thomas C Boothby
U G V S S Kumara
Storage of biological materials underpins medical, research, and biotechnological applications. Although cold-chain preservation is effective, it is costly, infrastructure-dependent, and vulnerable to disruption. Room-temperature dry storag...
AGTRAP mediates exosome-driven communication between cancer cells and macrophages via p38 MAPK pathway to promote hepatocellular carcinoma [0.03%]
AGTRAP通过p38 MAPK途径介导癌细胞和巨噬细胞之间的外泌体驱动通讯以促进肝细胞癌的发展
Shanshan Liu,Zhenghang Li,Hongqing Liu et al.
Shanshan Liu et al.
Background: Angiotensin II Receptor-Associated Protein (AGTRAP) is markedly overexpressed in hepatocellular carcinoma (HCC) cases associated with poor prognosis; however, its precise functional role remains inadequately e...
Collateral lethality of NAD kinase in 1p36 deleted tumors drives vulnerability to NAD kinase 2 depletion [0.03%]
1p36缺失肿瘤中NAD激酶的旁观者致死性导致其对NAD激酶2缺乏敏感
Saki Suyama-Banjo,Kengo Watanabe,Hirokazu Ishikawa et al.
Saki Suyama-Banjo et al.
The deletion of tumor suppressor genes often occurs in a tumor-specific manner and is accompanied by the unintended loss of adjacent genes. Nicotinamide adenine dinucleotide kinase (NADK), located at a tumor suppressive locus on chromosome ...
Structural modification of 5-alkyl-4-phenyl-thiazole-based fatty acid amide hydrolase and soluble epoxide hydrolase inhibitors to alleviate orofacial inflammatory pain in the rat [0.03%]
基于5-烷基-4-苯基噻唑的脂肪酸酰胺水解酶和可溶性环氧化物水解酶结构修饰以缓解大鼠颌面部炎症痛
Gabrielle Gorostiza,Madison Mercado,Lucy Pavana et al.
Gabrielle Gorostiza et al.
Orofacial pain is difficult to manage. Treatments like nonsteroidal anti-inflammatory drugs (NSAIDs), and serotonin agonists provide limited relief or produce side effects. These limitations highlight the need for alternative strategies tha...
Purinergic signaling modulates endothelial-to-mesenchymal transition in human aortic valve endothelial cells [0.03%]
嘌呤能信号调节人主动脉瓣内皮细胞向间充质细胞的转化
Vera Schmidt,Andreas Weber,Artur Lichtenberg et al.
Vera Schmidt et al.
Endothelial-to-mesenchymal transition (EndMT) is a phenotypic switch in which endothelial cells acquire mesenchymal characteristics, involving both functional and morphological changes. While EndMT is essential for cardiac development, its ...
Bioactive derivatives of the antimicrobial peptide esculentin-1a promote human dermal fibroblast migration and activate genes involved in early wound healing [0.03%]
抗菌肽_esculentin-1a的生物活性衍生物可促进人真皮成纤维细胞迁移及启动与早期伤口愈合相关的基因表达
Floriana Cappiello,Eleonora Grisard,Alice Traversa et al.
Floriana Cappiello et al.
Antimicrobial peptides (AMPs) are essential components of the innate immune system and have emerged as promising candidates against antibiotic-resistant infections. Beyond their antimicrobial activity, AMPs also play a crucial role in regul...
Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization [0.03%]
磷二酯酶1抑制剂通过促进微管稳定化增强紫杉醇细胞毒性：对MDA-MB-231衍生的乳腺癌细胞系的作用机制研究
Hsiao-Hui Kuo,Chien-Wei Huang,Tsai-Ming Lu et al.
Hsiao-Hui Kuo et al.
Resistance of tumor cells to chemotherapy remains a critical obstacle to effective cancer treatment. Although paclitaxel is one of the most commonly used chemotherapeutic agents for treating triple-negative breast cancer (TNBC), the mechani...
Fluid shear stress activates c-Src and promotes RANKL localization in the plasma membrane in osteoblast-like MC3T3-E1 cells [0.03%]
流体剪切应力激活c-Src并促进成骨细胞样MC3T3-E1细胞中RANKL在质膜上的定位
Takuma Matsubara,Anna Yoshimura,Shoichiro Kokabu
Takuma Matsubara
Receptor activator of NF-κB ligand (RANKL) produced by osteoblastic lineage cells is essential for osteoclastogenesis, yet RANKL can be sequestered in intracellular, lysosome-like compartments under basal conditions. How mechanical cues mo...
Adjacent domains drive the emergence of misfolded intermediates in the folding pathway of the PDZ4 from MAGI1 [0.03%]
相邻结构域驱动MAGI1PDZ4在折叠途径中错误折叠中间体的出现
Valeria Pennacchietti,Cosmin Marian Obreja,Dimitrios Marinidis et al.
Valeria Pennacchietti et al.
Protein misfolding in multidomain assemblies emerges from a complex interplay between intra- and interdomain interactions. Here, we dissect how neighboring domains shape the folding and misfolding of the PDZ4 domain from the scaffold protei...
TCA cycle intermediates as an adjunct strategy for human iPSC-derived cardiomyocyte maturation [0.03%]
TCA循环中间产物作为人多能干细胞源心肌细胞成熟的辅助策略
Keshav Narayan Alagarsamy,Emilee Bueckert,Mehak Gupta et al.
Keshav Narayan Alagarsamy et al.
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are a valuable tool for modeling cardiac diseases, drug testing, and regenerative applications. However, their application is limited by the immature phenotype of iPSC-CM....