Improving LC-MS/MS measurements of steroids with differential mobility spectrometry [0.03%]
基于不同迁移率谱的串联质谱法改善类固醇测量结果
Yubo Chai,Stefan K G Grebe,Anthony Maus
Yubo Chai
Introduction: Steroid measurements are important for diagnosis and monitoring of many conditions and treatment regiments; however, due to structural and chemical similarities amongst steroids, these analyses are challengi...
Assessing variations in manual pipetting: An under-investigated requirement of good laboratory practice [0.03%]
手工移液的差异性评估：良好实验习惯中被忽视的部分
Xue Li Guan,Dorothy Pei Shan Chang,Zhen Xuan Mok et al.
Xue Li Guan et al.
Pipettes are essential tools for biomedical and analytical laboratories, analogous to workstations for computer scientists. Variation in pipetting is a known unknown, as it is generally accepted that variations exist, but thus far, there ha...
GC-MS and GC-MS/MS measurement of malondialdehyde (MDA) in clinical studies: Pre-analytical and clinical considerations [0.03%]
临床研究中MDA的测量：样品前处理和临床方面应注意的问题
Dimitrios Tsikas
Dimitrios Tsikas
Malondialdehyde (MDA; 1,3-propanedial, OHC-CH2-CHO) is one of the most frequently measured biomarkers of oxidative stress in plasma and serum. L-Arginine (Arg) is the substrate of nitric oxide synthases (NOS), which convert L-arginine to ni...
Automated LC-MS/MS: Ready for the clinical routine Laboratory? [0.03%]
液相色谱-串联质谱法的自动化：准备好应用于临床常规实验室了吗？
Sina Junger,Miriam Hoene,Maria Shipkova et al.
Sina Junger et al.
Background: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a sensitive method with high specificity. However, its routine use in the clinical laboratory is hampered by its high complexity and lack of automat...
The pipetting Olympics: Propagating proper pipetting a priori in clinical LC-MS/MS analysis [0.03%]
移液奥林匹克运动会：临床LC-MS/MS分析中事先传播正确的移液方法
Matthew L Crawford,Christopher M Shuford,Russell P Grant
Matthew L Crawford
Introduction: Engaging pipetting events were developed to assess and challenge technicians' practical sample handling using matrices common to the clinical laboratory. As correct pipetting stands as a prerequisite for acc...
Practical considerations for accurate determination of free thyroxine by equilibrium dialysis [0.03%]
平衡透析法准确测定游离甲状腺素的实践问题考虑因素分析
Ashley Ribera,Li Zhang,Carla Ribeiro et al.
Ashley Ribera et al.
Background: Free thyroxine (FT4) measurement is one of the most requested tests in patient care for diagnosing and treating thyroid-related illnesses. Equilibrium dialysis (ED) is considered the "gold standard" for FT4 me...
Development and clinical application of a liquid chromatography-tandem mass spectrometry-based assay to quantify eight tyrosine kinase inhibitors in human plasma [0.03%]
一种同时测定人血浆中8种激酶抑制剂的液相色谱-串联质谱法的建立及临床应用研究
Fangjun Chen,Wenda Chen,Zhenxin Wang et al.
Fangjun Chen et al.
Introduction: Tyrosine kinase inhibitors (TKIs) are widely used in tumor treatment. The detection of these medicines by liquid chromatography-tandem mass spectrometry (LC-MS/MS) can avoid the interference of structurally ...
An introduction from the Laboratory Developed Tests special issue guest editors [0.03%]
特刊编辑：介绍实验室开发检测项目的现状及未来方向
Melissa M Budelier,Mark A Marzinke,Jacqueline A Hubbard
Melissa M Budelier
Analysis of monoclonal immunoglobulins from bone marrow plasma cells using immunopurification and LC-MS [0.03%]
免疫纯化和液相色谱质谱分析骨髓浆细胞单克隆免疫球蛋白
David R Barnidge,Angela Dispenzieri,Dragan Jevremovic et al.
David R Barnidge et al.
Introduction: Clonal plasma cells secrete immunoglobulins, each with the exact same amino acid sequence, that are referred to as monoclonal immunoglobulins. The monoclonal heavy chain and light chain secreted from clonal ...
A customized mass array panel for BCR:: ABL1 tyrosine kinase domain mutation screening in chronic myeloid leukemia [0.03%]
慢性粒细胞白血病BCR::ABL1酪氨酸激酶区突变检测的定制化微阵列基因分型面板
Nittaya Limsuwanachot,Budsaba Rerkamnuaychoke,Pimjai Niparuck et al.
Nittaya Limsuwanachot et al.
Introduction: The therapeutic strategy and management of chronic myeloid leukemia (CML) have rapidly improved with the discovery of effective tyrosine kinase inhibitors (TKIs) to target BCR::ABL1 oncoprotein. However, nea...