Therapeutic drug monitoring of glycopeptide antimicrobials: An overview of liquid chromatography-tandem mass spectrometry methods [0.03%]
糖肽类抗菌药物的治疗药物监测：液相色谱-串联质谱法概述
Alessia Cafaro,Sebastiano Barco,Federica Pigliasco et al.
Alessia Cafaro et al.
Therapeutic drug monitoring (TDM) is a critical clinical tool used to optimize the safety and effectiveness of drugs by measuring their concentration in biological fluids. These fluids are primarily plasma or blood. TDM, together with real-...
A high-throughput LC-MS/MS assay for piperaquine from dried blood spots: Improving malaria treatment in resource-limited settings [0.03%]
来自干血点的磷酸哌喹高通量LC-MS / MS检测方法：改善资源匮乏地区疟疾治疗条件
Daniel Blessborn,Natpapat Kaewkhao,Joel Tarning
Daniel Blessborn
Background: Malaria is a parasitic disease that affects many of the poorest economies, resulting in approximately 241 million clinical episodes and 627,000 deaths annually. Piperaquine, when administered with dihydroartem...
Michael Vogeser,Katharina Habler
Michael Vogeser
Development and validation of a liquid chromatography tandem mass spectrometry assay for the analysis of bedaquiline and M2 in breast milk [0.03%]
用于分析乳汁中贝达喹啉和M2的液相色谱串联质谱法的建立与验证
Buyisile Mkhize,Richard Court,Sandra Castel et al.
Buyisile Mkhize et al.
Objective: To develop and validate an assay for the analysis of bedaquiline and its M2 metabolite in human breast milk. Methods: The an...
Use of volumetric absorptive microsampling and parallel reaction monitoring mass spectrometry for tacrolimus blood trough measurements at home in pediatric heart transplant patients [0.03%]
体积吸收微采样和并行反应监测质谱法在家中测量儿科心脏移植患者的他克莫司血药谷值的应用
Junfang Zhao,Kenneth D R Setchell,Xueheng Zhao et al.
Junfang Zhao et al.
Background: Measurement of trough levels for calcineurin inhibitors by venipuncture sampling is a mainstay of patient management in solid organ transplant recipients but challenging in pediatric patients. Volumetric Absor...
Cheaper, faster, simpler trypsin digestion for high-throughput targeted protein quantification [0.03%]
低成本、快速简便的蛋白酶消化法在高通量目标蛋白质定量中的应用
Christopher M Shuford,Russell P Grant
Christopher M Shuford
Introduction: LC-MS-based methods for protein quantification have a stigma of being relatively expensive and low-throughput. This is partly due to the cost and speed of trypsin digestion, which has primarily focused on ad...
Exploring Streptococcus pneumoniae capsular typing through MALDI-TOF mass spectrometry and machine-learning algorithms in Argentina: Identifying prevalent NON PCV13 serotypes alongside PCV13 serotypes [0.03%]
通过基质辅助激光解吸电离飞行时间质量测定和机器学习算法在阿根廷探索肺炎链球菌荚膜分型：除PCV13血清型外，同时确定流行的非PCV13血清型
Jonathan Zintgraff,Florencia Rocca,Nahuel Sánchez Eluchans et al.
Jonathan Zintgraff et al.
Introduction: Laboratory surveillance of Streptococcus pneumoniae serotypes plays a crucial role in effectively implementing vaccines to prevent invasive pneumococcal diseases. The conventional method of serotyping, known...
Molecular and translational biology of the blood-based VeriStrat® proteomic test used in cancer immunotherapy treatment guidance [0.03%]
基于血液的VeriStrat蛋白质组学检测在癌症免疫治疗指导中的分子和转化生物学研究
Matthew A Koc,Timothy Aaron Wiles,Daniel C Weinhold et al.
Matthew A Koc et al.
Introduction: The VeriStrat® test (VS) is a blood-based assay that predicts a patient's response to therapy by analyzing eight features in a spectrum obtained from matrix-assisted laser desorption/ionization time-of-flig...
Matrix-matched calibrators are necessary for robust and high-quality dried blood spots lead screening assays by inductively coupled plasma-mass spectrometry [0.03%]
矩阵匹配基质校准物构建的电感耦合等离子体质谱法快速筛查干血斑中铅的方法研究
Jessica M Colón Franco,Rogers A Muldrow,Wendy Cieslak et al.
Jessica M Colón Franco et al.
Background and aims: Reliable lead screening methods are necessary to support early identification of lead exposure in children. Sample collection using dried blood spots (DBS) offers advantages compared to traditional ve...
Comparison of liquid chromatography-high-resolution tandem mass spectrometry (MS2) and multi-stage mass spectrometry (MS3) for screening toxic natural products [0.03%]
液相色谱高分辨率串联质谱(MS2)与多级质谱(MS3)筛查毒害性天然产物的比较研究
Ruben Yiqi Luo,Kate Comstock,Caroline Ding et al.
Ruben Yiqi Luo et al.
Background: Liquid chromatography-high-resolution mass spectrometry (LC-HR-MS) has emerged as a powerful analytical technology for compound screening in clinical toxicology. To evaluate the potential of LC-HR-MS3 in detec...