Pseudo-hypertriglyceridemia in a 2-year-old male with global developmental delay, myopathy and adrenal hypoplasia [0.03%]
发育迟缓、肌病和肾上腺发育不全的两岁男童伪高甘油三酯血症
Xiaowei Fu,Claire P Williamson,Kerri Bosfield
Xiaowei Fu
Pseudo-hypertriglyceridemia is an overestimation of serum triglyceride levels due to laboratory assays that measure free glycerol concentrations instead of triglycerides directly. Consequently, conditions presenting with elevated levels of ...
Endogenous monoclonal immunoglobulins analyzed using the EXENT® solution and LC-MS [0.03%]
使用EXENT®解决方案和液相色谱-质谱分析内源性单克隆免疫球蛋白
David Barnidge,Derek Troske,Simon North et al.
David Barnidge et al.
Introduction: The EXENT® Solution, a fully automated system, is a recent advancement for identifying and quantifying monoclonal immunoglobulins in serum. It combines immunoprecipitation with MALDI-TOF mass spectrometry. ...
Infliximab Therapeutic monitoring by tryptic peptide LC-MS/MS method improvements lead to improved accuracy with decreased imprecision and turnaround time [0.03%]
通过胰蛋白酶肽LC-MS / MS方法改进英夫利昔单抗治疗监测以提高准确性，降低不精确性和周转时间
Paula M Ladwig,Ann L Rivard,Alex Barbeln et al.
Paula M Ladwig et al.
Introduction: Therapeutic drug monitoring of infliximab has become the standard of care for inflammatory bowel disease in the setting of loss of response to therapy, and occasionally in proactive therapy personalization. ...
Bioanalysis of bedaquiline in human plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study [0.03%]
液相色谱-串联质谱法分析人血浆中的贝达喹啉：在药代动力学研究中的应用
Viritha Bezawada,Padma Mogili,Srinivasa Rao Polagani et al.
Viritha Bezawada et al.
Introduction: A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for estimation of bedaquiline (BDQ) in human plasma using the deuterated analogue of the analyte, bedaquiline-d6 (BD...
Development and validation of a multiplexed LC-MS/MS ketone body assay for clinical diagnostics [0.03%]
用于临床诊断的多路复用液相色谱-串联质谱酮体检测方法的研发与验证
Robin H J Kemperman,Rebecca D Ganetzky,Stephen R Master
Robin H J Kemperman
Objectives: Ketone bodies (KBs) serve as important energy sources that spare glucose, providing the primary energy for cardiac muscle, skeletal muscle during aerobic exercise, and the brain during periods of catabolism. T...
An LC-MS/MS-based platform for the quantification of multiple amyloid beta peptides in surrogate cerebrospinal fluid [0.03%]
基于LC-MS / MS的平台，用于 surrogate 脑脊液中多种淀粉样蛋白β肽的定量分析
Merve Oztug,Bilgin Vatansever,Gonca Altin et al.
Merve Oztug et al.
Introduction: The accurate quantification of amyloid beta (Aβ) peptides in cerebrospinal fluid (CSF) is crucial for Alzheimer's disease (AD) research, particularly in terms of preclinical and biomarker studies. Tradition...
Electrospray triple quadrupole mass spectrometry guides pathologists to suggest appropriate molecular testing in the identification of rare hemoglobin variants [0.03%]
电喷射三重四极杆质谱引导病理科提出识别罕见血红蛋白变异体的适当分子检测建议
Deepalakshmi Dakshinamoorthy Putchen,Athira Nambiar,Aswathy Ashok Menon et al.
Deepalakshmi Dakshinamoorthy Putchen et al.
Background: The presumptive diagnosis of hemoglobinopathies relies on routine tests such as Complete Blood Count (CBC), peripheral blood smear, Liquid Chromatography (LC), and Capillary Electrophoresis (CE), along with cl...
A validated liquid chromatography-tandem mass spectrometry assay for the analysis of isoniazid and its metabolite acetyl-isoniazid in urine [0.03%]
尿液中异烟肼及其代谢物乙酰异烟肼的液相色谱-串联质谱检测方法的验证研究
Sydwell Poulo Maputla,Willem Van Dalen,Anton Joubert et al.
Sydwell Poulo Maputla et al.
Introduction: Isoniazid (INH) is one of the most effective and potent first-line anti-tubercular drug. INH is also effectively administered as a preventative monotherapy and has been shown to significantly reduce TB incid...
David S Millington
David S Millington
This article offers a personal account of a remarkable journey spanning over 30 years of applied mass spectrometry in a clinical setting. It begins with the author's inspiration from a clinician's story of rescuing a child from near death w...
Enhancing saliva diagnostics: The impact of amylase depletion on MALDI-ToF MS profiles as applied to COVID-19 [0.03%]
唾液诊断的改进：淀粉酶耗竭对COVID-19中MALDI-ToF 质谱分析的影响
Zane LaCasse,Prajkta Chivte,Kari Kress et al.
Zane LaCasse et al.
Introduction: Human saliva contains a wealth of proteins that can be monitored for disease diagnosis and progression. Saliva, which is easy to collect, has been extensively studied for the diagnosis of numerous systemic a...