Impact of internal standard selection on measurement results for long chain fatty acids in blood [0.03%]
内标选择对血液中长链脂肪酸测定结果的影响
John M Goodwin,Heather C Kuiper,Barrett Brister et al.
John M Goodwin et al.
Introduction: Internal standards correct for measurement variation due to sample loss. Isotope labeled analytes are ideal internal standards for the measurement of fatty acids in human plasma but are not always readily av...
Comparison between a single- and a multi-point calibration method using LC-MS/MS for measurement of 5-fluorouracil in human plasma [0.03%]
LC-MS/MS测定人血浆中5-氟尿嘧啶的单点校正与多点校正比较研究
Mirjana Radovanovic,Jennifer J Schneider,Jennifer H Martin et al.
Mirjana Radovanovic et al.
When quantifying therapeutic drugs using LC-MS/MS instrumentation in clinical laboratories, batch-mode analysis with a calibration curve consisting of 6-10 concentrations for each analyte is the most widely used approach. However, this is a...
Corrigendum to "Development and validation of a multiplexed LC-MS/MS ketone body assay for clinical diagnostics" [J. Mass Spectrom. Adv. Clin. Lab 31 (2024) 49-58] [0.03%]
“临床诊断用多路LC-MS/MS酮体测定法的开发与验证”勘误注释[J. Mass Spectrom. Adv. Clin. Lab 31 (2024) 49-58]
Robin H J Kemperman,Rebecca D Ganetzky,Stephen R Master
Robin H J Kemperman
[This corrects the article DOI: 10.1016/j.jmsacl.2024.01.004.]. © 2024 THE AUTHORS.
Despite the improved clinical sensitivity of the Roche benzodiazepines II assay it cannot replace mass spectrometry in all patient populations [0.03%]
尽管罗氏苯二氮卓类二代检测试剂盒的临床敏感性有所提高，但其仍不能替代所有人群样本的质谱检测方法
Nicole V Tolan,Sacha Uljon,M Lauren Donnelly-Morell et al.
Nicole V Tolan et al.
Introduction: Benzodiazepines are frequently prescribed and misused therefore urine drug screening (UDS) is performed in many patient populations. Most current benzodiazepine immunoassays have poor sensitivity, particular...
Therapeutic drug monitoring of mycophenolic acid and azole antifungals on two distinct LC-MS/MS instruments [0.03%]
基于两种不同的LC-MS/MS平台检测麦考酚酸和唑类抗真菌药的治疗药物监测方法
Jill K Wolken,Wenjing Cao,Min Cui et al.
Jill K Wolken et al.
Background: As an active metabolite of a commonly prescribed immunosuppressant, mycophenolic acid (MPA) levels are often monitored to prevent organ rejection following a transplant. Triazoles are often prescribed for trea...
Spuriously low immunosuppressant results due to incomplete hemolysis - A pitfall in transplant patient therapeutic drug monitoring [0.03%]
溶血不全导致免疫抑制剂假性低浓度结果——移植患者治疗药物监测中的一个陷阱
Michael Vogeser,Katharina Habler
Michael Vogeser
Objective: Therapeutic drug monitoring (TDM) plays a crucial role in transplantation medicine when it comes to immunosuppressants like Tacrolimus, Cyclosporine A, Sirolimus, and Everolimus. The analysis involves using imm...
Kelly Britt-Rodriquez,Jamie Daniel,Joshua Hayden
Kelly Britt-Rodriquez
Liquid handlers (LHs) have become common in both clinical and academic laboratories for the preparation and manipulation of samples. In theory, these systems offer the potential for reduced error due to the elimination of mis-pipetting erro...
Quantitation of propofol metabolites by LC-MS/MS demonstrating long detection window for urine drug monitoring [0.03%]
定量测定丙泊酚代谢产物的LC-MS/MS方法及其在尿药监测中长时间检测窗口的验证研究
Thomas G Rosano,Michelle Wood,Kiley L Scholz et al.
Thomas G Rosano et al.
Introduction: Chromatographic methods for analysis of propofol and its metabolites have been widely used in pharmacokinetic studies of propofol distribution, metabolism, and clearance. Application of chromatographic metho...
Development and validation of an LC-MSMS method to quantify creatinine from dried blood spots [0.03%]
用于从干燥血斑中定量测定肌酐的LC-MS-MS方法的开发与验证
Carlos Torres,Rogers A Muldrow,Anissa R Naranjo et al.
Carlos Torres et al.
Introduction: Screening for chronic kidney disease relies on accurate and precise creatinine measurements. Traditionally, creatinine is measured in serum or plasma using high-throughput chemistry analyzers. However, dried...
Therapeutic drug monitoring of clozapine in human serum by high-throughput paper spray mass spectrometry [0.03%]
高通量纸喷雾质谱法在人血清中对氯氮平进行治疗药物监测
A Saatchi,T M Zarkovic,S A Borden et al.
A Saatchi et al.
Introduction: Monitoring the atypical antipsychotic drug clozapine is crucial to ensure patient safety. This article showcases a high-throughput analytical method for measuring clozapine and its primary metabolite norcloz...