Development and clinical utility of an ultra performance liquid chromatography - tandem mass spectrometry assay for monitoring omadacycline and tigecycline in severe bacterial infections [0.03%]
用于监测严重细菌感染中奥马达西林和替加环素的超高效液相色谱-串联质谱检测方法的开发及临床效用
Chang Wang,Bingfeng Luo,Wenqing Liu et al.
Chang Wang et al.
Objective: We aimed to develop a rapid, simple, and precise ultra performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) technique for simultaneous measurement of omadacycline (OMA) and tigecycline (TGC...
Tandem mass spectrometry of serum cholestanoic (C27) acids - Typical concentration ranges and application to the study of peroxisomal biogenesis disorders [0.03%]
血清胆固醇酸（C27）的串联质谱：典型浓度范围及其在过氧化物酶体生物发生障碍研究中的应用
Wujuan Zhang,Monica Narvaez Rivas,Kenneth D R Setchell
Wujuan Zhang
Background: Primary bile acid synthesis is impaired in peroxisomal disorders, leading to the accumulation of long-chain bile acids, specifically dihydroxycholestanoic and trihydroxycholestanoic acids. Quantification of th...
Research letter: Pilot study of a prototype fully automated mass spectrometry system for routine clinical laboratory use [0.03%]
研究信函：临床实验室使用全自动质谱仪系统初步研究原型机
Michael Vogeser,Katharina Habler,Antje Reuter et al.
Michael Vogeser et al.
Development and validation of an LC-MS/MS method for highly concentrated tacrolimus and cyclosporine samples prepared from pharmaceutical products to assess drug loss from feeding tubes [0.03%]
开发和验证LC-MS/MS方法以评估从给药管中损失的高浓度环孢素和他克莫司药物样品
Yi Xiao,Mari Ishak Gabra,Edward Leung
Yi Xiao
Introduction: Tacrolimus and cyclosporine are common immunosuppressants utilized post-organ transplantation to manage allograft rejection. Both have narrow therapeutic indices and are frequently measured to support dose a...
Liquid chromatography-mass spectrometric method for the simultaneous analysis of branched-chain amino acids and their ketoacids from dried blood spot as secondary analytes for the detection of maple syrup urine disease [0.03%]
一种同时测定支链氨基酸及其酮酸的液相色谱-串联质谱法用于枫糖尿病的确诊指标标记物检测
Arya Raveendran,Ashutosh Gupta,Leslie E Lewis et al.
Arya Raveendran et al.
Background: Maple syrup urine disease (MSUD) is an aminoacidopathy caused by a defective branched-chain alpha-ketoacid dehydrogenase complex, leading to the accumulation of branched-chain amino acids (BCAAs) and their res...
Method validation of an inductively coupled plasma mass spectrometry (ICP-MS) assay for the analysis of magnesium, copper and zinc in red blood cells [0.03%]
用于分析红细胞中镁、铜和锌的电感耦合等离子体质谱法（ICP-MS）测定方法验证
Nazmin Bithi,Daniel Ricks,Brandon S Walker et al.
Nazmin Bithi et al.
Background: Laboratory measurements of trace elements such as magnesium (Mg), copper (Cu), and zinc (Zn) in red blood cells (RBCs) are essential for assessing nutritional status and diagnosing metal toxicity. The purpose ...
Rapid and sensitive liquid chromatographic-tandem mass spectrometric methods for the quantitation of dolutegravir in human plasma and breast milk [0.03%]
一种快速灵敏的测定人血浆和乳汁中多替拉韦的方法
Ashley R Rackow,Aashish Pandey,Amelia L Price et al.
Ashley R Rackow et al.
Background: Dolutegravir (DTG) is part of a first-line antiretroviral therapy (ART) for HIV management in drug-naïve individuals and is recommended for the treatment of HIV during pregnancy. Robust analytical tools to qu...
Katharina Habler,Arber Rexhaj,Manuela Adling-Ehrhardt et al.
Katharina Habler et al.
Mass spectrometry (MS) is a versatile analytical tool used in various fields such as biochemistry, pharmacology, omics, and clinical analysis for determining and quantifying compounds based on their molecular mass and structure through the ...
Isotope-dilution-LC-MS/MS candidate reference measurement procedure for cefepime in human serum [0.03%]
人血清中头孢吡肟的同位素稀释LC-MS/MS候选参考测量程序
Judith Schäffler,Michael Vogeser,Katharina Habler
Judith Schäffler
Background: Reference measurement procedures are an essential element in the standardization and comparability of analytical measurement results in laboratory medicine. No LC-MS/MS-based reference measurement procedure fo...
Rapid identification of SARS CoV-2 omicron sub-variant JN.1 (BA.2.86.1.1) with mass spectrometry [0.03%]
基于质谱的SARS-CoV-2奥密克戎次变体JN.1（BA.2.86.1.1）快速识别方法
Henry E Lanyon,Kevin M Downard
Henry E Lanyon
Objective: The rapid detection and differentiation of strains of the BA.2.86 lineage including the new sub-variant JN.1 (BA.2.86.1.1) is demonstrated employing selected ion monitoring (SIM) and high resolution mass spectr...