Increased extracellular vesicles (EVs) related to T cell-mediated inflammation and vascular function in familial hypercholesterolemia [0.03%]
在家族性高胆固醇血症中T细胞介导的炎症和血管功能相关的细胞外囊泡(EVs)增多
Morten Hjuler Nielsen,Rikke Bæk,Malene Moller Jorgensen et al.
Morten Hjuler Nielsen et al.
Background and aims: OxLDL modulates innate and adaptive immunity, and extracellular vesicles (EVs) released from both non-immune and immune cells are proposed key players in atherosclerosis development. In the present st...
The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction [0.03%]
他汀治疗的心梗患者使用羟氯喹对胆固醇代谢的影响研究
Lotta Ulander,Piia Simonen,Heli Tolppanen et al.
Lotta Ulander et al.
Background and aims: To evaluate the effect of hydroxychloroquine (HCQ) on serum and lipoprotein lipids and serum biomarkers of cholesterol synthesis and absorption in myocardial infarction patients with a high-dose stati...
The German CaRe high registry for familial hypercholesterolemia - Sex differences, treatment strategies, and target value attainment [0.03%]
德国CaRe办公室高胆固醇血症家系注册研究：性别差异、治疗策略及目标实现状况
Winfried März,Nina Schmidt,Ira An Haack et al.
Winfried März et al.
Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotei...
Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy [0.03%]
颈动脉内膜剥脱术后外周血细胞特征与主要心血管不良事件的独立关系分析
L Malin Overmars,Joost M Mekke,Wouter W van Solinge et al.
L Malin Overmars et al.
Background and aims: Patients who underwent carotid endarterectomy (CEA) still have a residual risk of 13% of developing a major adverse cardiovascular event (MACE) within 3 years. Inflammatory processes leading up to MAC...
SARS-CoV-2 reinfection: Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease [0.03%]
新冠病毒再感染：在动脉粥样硬化性心血管病患者中对功能失调的内皮细胞造成进一步损害
Petri T Kovanen,Alpo Vuorio
Petri T Kovanen
In this short narrative review, we aim at defining the pathophysiological role endothelial dysfunction in the observed COVID-19-associated rise in risk of cardiovascular disease. Variants of the SARS-CoV-2 virus have caused several epidemic...
Fibronectin extra domain a limits liver dysfunction and protects mice during acute inflammation [0.03%]
纤维连接蛋白额外区段A限制肝功能障碍并在急性炎症期间保护小鼠
Vivek Krishna Pulakazhi Venu,Annalisa Moregola,Lorenzo Da Dalt et al.
Vivek Krishna Pulakazhi Venu et al.
Background and aim: The primary transcript of fibronectin (FN) undergoes alternative splicing to generate different isoforms, including FN containing the Extra Domain A (FN_EDA+), whose expression is regulated spatially a...
David Leibowitz,Yuriko Yoshida,Zhezhen Jin et al.
David Leibowitz et al.
Background and aims: The presence of aortic arch plaques (AAP) is significantly associated with increased cardiovascular morbidity and mortality. Few studies have examined the incidence of AAP progression and factors whic...
Chiara Pavanello,Alice Ossoli
Chiara Pavanello
Low HDL-cholesterol (HDL-C) concentrations are a typical trait of the dyslipidemia associated with chronic kidney disease (CKD). In this condition, plasma HDLs are characterized by alterations in structure and function, and these particles ...
Associations of urinary isoprostanes with measures of subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA) [0.03%]
尿液异前列酮与亚临床动脉粥样硬化的测量指标的关系：多元民族动脉粥样硬化研究（MESA）中的发现
Ryan L Wallace,Oluseye Ogunmoroti,Di Zhao et al.
Ryan L Wallace et al.
Background: Urinary isoprostanes are markers of systemic oxidative stress, which is implicated in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Coronary artery calcium (CAC), thoracic aortic calcium ...
Johan Skov Bundgaard,Marit E Jørgensen,Kristine Andersen et al.
Johan Skov Bundgaard et al.
Background: Low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for development of cardiovascular diseases. Based on available clinical data, we aimed to investigate the plasma lipid profile in t...