Cholesterol in amyotrophic lateral sclerosis: a bystander, a biomarker, or a target? [0.03%]
胆固醇与肌萎缩侧索硬化症：肇事者、生物标志物还是治疗靶点？
Matteo Farè,Chiara Comi,Giulia Susanna Ferrero et al.
Matteo Farè et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. In addition to the different pathogenic mechanisms, in recent years, increasing attention has been directed toward the...
LDL-cholesterol distance to target: A practical tool for guiding lipid-lowering treatment decisions [0.03%]
LDL胆固醇目标值差距：指导降脂治疗决策的实用工具
Maria Chiara Palloni,Teresa Farella,Andrea Faggiano et al.
Maria Chiara Palloni et al.
Low-density lipoprotein cholesterol (LDL-C) is causal in atherosclerotic cardiovascular disease (ASCVD), still the leading causes of global morbidity and mortality. The 2025 update of the ESC/EAS guidelines for the management of dyslipidemi...
Effects of evolocumab on plasma coenzyme Q10 in patients with heterozygous familial hypercholesterolemia [0.03%]
Evolocumab对杂合子家族性高胆固醇血症患者血浆辅酶Q10的影响
Hayato Tada,Yasuaki Takeji,Masayuki Takamura
Hayato Tada
Background and aims: Muscle symptoms are common with statin therapy, and reduced plasma coenzyme Q10 (CoQ10) has been proposed as a potential mechanism. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are...
Awareness and perceptions of systemic inflammation in atherosclerotic cardiovascular disease and chronic kidney disease: The SPARK-CVD China survey [0.03%]
中国SPARK-CVD调查：动脉粥样硬化性心血管疾病和慢性肾脏病患者全身炎症的认知与感知
Xiaoxia Liu,Yuanlin Guo,Ban Zhao et al.
Xiaoxia Liu et al.
Background and aims: Cardiovascular disease (CVD) remains a leading cause of death in China. Systemic inflammation (SI) is an emerging risk factor in atherosclerotic CVD (ASCVD) and chronic kidney disease (CKD). High-sens...
Retinal findings in familial hypercholesterolemia: An exploratory case-control study [0.03%]
黄脂蛋白血症的视网膜病变一项病例对照研究
Gisle Langslet,Synne Kollstad,Øystein Kalsnes Jørstad et al.
Gisle Langslet et al.
Background and aims: Patients with familial hypercholesterolemia (FH) have elevated LDL-C levels from birth and increased risk of cardiovascular disease due to atherosclerosis, mostly affecting larger arteries. Less is kn...
Lipoprotein metabolism and inflammation in healthy young subjects - exploring the postprandial and postabsorptive phases following intake of a standardized meal [0.03%]
健康年轻人中的血脂代谢和炎症反应——探究标准餐后进食后的餐后及餐后吸收阶段的情况
Silje-Marie Jensen,Kirsten B Holven,Stine M Ulven et al.
Silje-Marie Jensen et al.
Background and aims: Commonly measured cardiometabolic biomarkers have not been systematically characterized across the long-term continuum of the postprandial and postabsorptive phases. The aim of the present study was t...
Association of the C-reactive protein-triglyceride-glucose index (CTI) with lower-extremity peripheral artery disease among U.S. adults [0.03%]
C-反应蛋白-甘油三酯-血糖指数与美国成年人下肢外周动脉疾病的关系
Sahil Ghay,Baneet Kaur,Agata Piotrowska et al.
Sahil Ghay et al.
Introduction: Peripheral artery disease (PAD) is a common yet underrecognized consequence of systemic atherosclerosis, affecting over 200 million adults worldwide and one in five older adults in the United States. PAD car...
Expert consensus on Lipoprotein(a) in the Gulf countries: Navigating cardiovascular risk and therapeutic advances [0.03%]
海湾国家脂蛋白(a)专家共识：心血管风险和治疗进展导航
Wael Almahmeed,Hani Sabbour,Ronney Shantouf et al.
Wael Almahmeed et al.
Background: Lipoprotein(a) [Lp(a)] is increasingly recognized as an independent and causal risk factor for atherosclerotic cardiovascular (CV) disease including aortic valve stenosis, myocardial infarction, stroke, periph...
Parallel screening strategies reveal distinct phenotypic and genotypic profiles of familial hypercholesterolemia in children and adults [0.03%]
平行筛查策略揭示儿童和成人家族性高胆固醇血症的不同表型和基因型特征
Jaka Sikonja,Urska Intihar,Borut Jug et al.
Jaka Sikonja et al.
Background: Multiple familial hypercholesterolemia (FH) screening strategies are recommended, but how they work together within a population remains poorly understood. Here, we aimed to compare the characteristics of chil...
Environmental pollution, apolipoprotein A-1 autoantibodies and cardiovascular risk: evidence from a geospatial cross-sectional study [0.03%]
环境污染物、载脂蛋白A-1自身抗体和心血管风险：来自地理空间横断面研究的证据
Noé Fellay,Sabrina Pagano,Pedro Marques-Vidal et al.
Noé Fellay et al.
Aims: Autoantibodies against apolipoprotein A-1 (AAA1) are independent cardiovascular risk factor in the general population. Genetic factors and viral infections have been linked to AAA1 occurrence. We studied the associa...