Executive summary of the Hellenic Atherosclerosis Society guidelines for the diagnosis and treatment of dyslipidemias - 2023 [0.03%]
希腊动脉硬化学会2023年血脂异常诊断与治疗指南摘要
N Katsiki,Td Filippatos,C Vlachopoulos et al.
N Katsiki et al.
Atherosclerotic cardiovascular disease (ASCVD) remains the main cause of death worldwide, and thus its prevention, early diagnosis and treatment is of paramount importance. Dyslipidemia represents a major ASCVD risk factor that should be ad...
Refined metabolite profiling in the collateral circulation of chronic total occlusion of coronary arteries: Insights from a metabolomics investigation [0.03%]
冠状动脉慢性完全闭塞侧支循环的精准代谢物谱分析：一项代谢组学研究带来的启示
Hu Sigan,Li Min,Cheng Zengwei et al.
Hu Sigan et al.
Background and aims: To investigate the disparities in coronary collateral circulation (CCC) and peripheral serum metabolites among patients presenting with chronic total occlusion (CTO) of the coronary arteries, a non-ta...
Changing from lipoprotein apheresis to evolocumab treatment lowers circulating levels of arachidonic acid and oxylipins [0.03%]
从脂蛋白去除术转变为evolocumab治疗可降低循环中的花生四烯酸和氧合衍生物的水平
Chaoxuan Wang,Anne Kaufmann,Nadja Kampschulte et al.
Chaoxuan Wang et al.
Background and aims: Previous studies have shown that lipoprotein apheresis can modify the plasma lipidome and pro-inflammatory and pro-thrombotic lipid mediators. This has not been examined for treatment with protein con...
Endothelial dysfunction and cardiovascular diseases in people living with HIV on specific highly active antiretroviral therapy regimen: A systematic review of clinical studies [0.03%]
特定高效抗逆转录病毒治疗方案对HIV感染者的内皮功能障碍和心血管疾病的影响：临床研究系统回顾
Haskly Mokoena,Sihle E Mabhida,Joel Choshi et al.
Haskly Mokoena et al.
Despite the improved efficacy of highly active antiretroviral therapy (HAART) in viral suppression, emerging evidence indicates an increased burden of noncommunicable diseases in people living with HIV (PLWH). Immune activation and persiste...
Associations of carotid atherosclerosis with cognitive function and brain health: Findings from a UK tri-ethnic cohort study (Southall and Brent Revisited) [0.03%]
颈动脉粥样硬化与认知功能和脑健康的关系：来自英国三项民族队列研究(重返南阿勒和布伦特)的发现
Rayan Anbar,Siana Jones,Nish Chaturvedi et al.
Rayan Anbar et al.
Background: Cognitive function has an important role in determining the quality of life of older adults. Cardiovascular disease (CVD) is common in older people and may compromise cognitive performance; however, the extent...
The atorvastatin metabolite pattern in muscle tissue and blood plasma is associated with statin muscle side effects in patients with coronary heart disease; An exploratory case-control study [0.03%]
肌肉组织和血浆中的阿托伐他汀代谢物模式与冠心病患者出现的他汀类药物肌不良反应有关；一项探索性的病例对照研究
Trine Lauritzen,John Munkhaugen,Stein Bergan et al.
Trine Lauritzen et al.
Background and aims: Statin-associated muscle symptoms (SAMS) is a prevalent cause of statin discontinuation. It is challenging and time-consuming for clinicians to assess whether symptoms are caused by the statin or not,...
Conditional deletion of Ccl2 in smooth muscle cells does not reduce early atherosclerosis in mice [0.03%]
平滑肌细胞中Ccl2的条件性删除并不能减少小鼠早期的动脉粥样硬化病变
Stine Gunnersen,Jeong Tangkjær Shim,Fan Liu et al.
Stine Gunnersen et al.
Background and aims: C-C motif chemokine ligand 2 (CCL2) is a pro-inflammatory chemokine important for monocyte recruitment to the arterial wall and atherosclerotic plaques. Global knockout of Ccl2 reduces plaque formatio...
Acute myocardial infarction preferentially alters low-abundant, long-chain unsaturated phospholipid and sphingolipid species in plasma high-density lipoprotein subpopulations [0.03%]
急性心肌梗塞优先改变血浆高密度脂蛋白亚群中的低丰度长链不饱和磷脂和鞘脂种类
Maharajah Ponnaiah,Emile Zakiev,Marie Lhomme et al.
Maharajah Ponnaiah et al.
Aim: High-density lipoprotein (HDL) particles in ST-segment elevation myocardial infarction (STEMI) are deficient in their anti-atherogenic function. Molecular determinants of such deficiency remain obscure. ...
Plasma lipids in Pseudoxanthoma Elasticum (PXE) patients: A comparative study with population-based reference values and Non-PXE controls [0.03%]
弹性假黄瘤(PXE)患者的血浆脂类：与人群基础参考值及非PXE对照组的比较研究
Iris M Harmsen,Frank L J Visseren,Madeleine Kok et al.
Iris M Harmsen et al.
Background and aims: - Pseudoxanthoma elasticum (PXE) is a rare genetic disease caused by pathogenic mutations in the ABCC6 gene, resulting in low values of inorganic pyrophosphate (PPi). While low PPi is thought to contr...
CTCA in children with severe heterozygous familial hypercholesterolaemia: Screening for subclinical atherosclerosis [0.03%]
严重杂合子家族性高胆固醇血症儿童中的冠脉计算机断层扫描造影：筛查无症状动脉粥样硬化
M Doortje Reijman,Sibbeliene E van den Bosch,D Meeike Kusters et al.
M Doortje Reijman et al.
Familial hypercholesterolemia (FH) is one of the most common genetically inherited disorders in the world. Children with severe heterozygous FH (HeFH), i.e. untreated low-density lipoprotein cholesterol (LDL-C) levels above the 90th percent...