Glucagon-like Peptide-1 analogues and delipidation of coronary atheroma in statin-treated type 2 diabetic patients with coronary artery disease: The prespecified sub-analysis of the OPTIMAL randomized clinical trial [0.03%]
利拉鲁肽与他汀治疗的2型糖尿病冠心病患者冠状动脉斑块脱脂：OPTIMAL随机临床试验的预设子分析研究
Yu Kataoka,Satoshi Kitahara,Sayaka Funabashi et al.
Yu Kataoka et al.
Background and aims: Randomized clinical trials have demonstrated the ability of glucagon-like peptide-1 analogues (GLP-1RAs) to reduce atherosclerotic cardiovascular disease events in patients with type 2 diabetes (T2D)....
Treatment intensification with bempedoic acid to achieve LDL-C goal in patients with ASCVD: A simulation model using a real-world patient cohort in the US [0.03%]
在ASCVD患者中使用贝梅普 Dor 酸强化治疗以达到LDL-C目标：基于美国真实世界患者队列的模拟模型
Kristen Migliaccio-Walle,David Elsea,Anand Gupta et al.
Kristen Migliaccio-Walle et al.
Background and aims: Guidelines recommend that high-risk patients with atherosclerotic cardiovascular disease (ASCVD) be treated with maximally tolerated statins to lower low-density lipoprotein cholesterol (LDL-C) levels...
The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study [0.03%]
羟氯喹对胆固醇合成的影响取决于胆固醇代谢的特性。一项控制临床研究
Piia Simonen,Lotta Ulander,Kari K Eklund et al.
Piia Simonen et al.
Background and aims: Hydroxychloroquine (HCQ) has a variable effect on cholesterol synthesis. To clarify this, we assessed the effect of HCQ on the cholesterol-synthesis pathway in individuals with low and high cholestero...
Executive summary of the Hellenic Atherosclerosis Society guidelines for the diagnosis and treatment of dyslipidemias - 2023 [0.03%]
希腊动脉硬化学会2023年血脂异常诊断与治疗指南摘要
N Katsiki,Td Filippatos,C Vlachopoulos et al.
N Katsiki et al.
Atherosclerotic cardiovascular disease (ASCVD) remains the main cause of death worldwide, and thus its prevention, early diagnosis and treatment is of paramount importance. Dyslipidemia represents a major ASCVD risk factor that should be ad...
Refined metabolite profiling in the collateral circulation of chronic total occlusion of coronary arteries: Insights from a metabolomics investigation [0.03%]
冠状动脉慢性完全闭塞侧支循环的精准代谢物谱分析：一项代谢组学研究带来的启示
Hu Sigan,Li Min,Cheng Zengwei et al.
Hu Sigan et al.
Background and aims: To investigate the disparities in coronary collateral circulation (CCC) and peripheral serum metabolites among patients presenting with chronic total occlusion (CTO) of the coronary arteries, a non-ta...
Changing from lipoprotein apheresis to evolocumab treatment lowers circulating levels of arachidonic acid and oxylipins [0.03%]
从脂蛋白去除术转变为evolocumab治疗可降低循环中的花生四烯酸和氧合衍生物的水平
Chaoxuan Wang,Anne Kaufmann,Nadja Kampschulte et al.
Chaoxuan Wang et al.
Background and aims: Previous studies have shown that lipoprotein apheresis can modify the plasma lipidome and pro-inflammatory and pro-thrombotic lipid mediators. This has not been examined for treatment with protein con...
Endothelial dysfunction and cardiovascular diseases in people living with HIV on specific highly active antiretroviral therapy regimen: A systematic review of clinical studies [0.03%]
特定高效抗逆转录病毒治疗方案对HIV感染者的内皮功能障碍和心血管疾病的影响：临床研究系统回顾
Haskly Mokoena,Sihle E Mabhida,Joel Choshi et al.
Haskly Mokoena et al.
Despite the improved efficacy of highly active antiretroviral therapy (HAART) in viral suppression, emerging evidence indicates an increased burden of noncommunicable diseases in people living with HIV (PLWH). Immune activation and persiste...
Associations of carotid atherosclerosis with cognitive function and brain health: Findings from a UK tri-ethnic cohort study (Southall and Brent Revisited) [0.03%]
颈动脉粥样硬化与认知功能和脑健康的关系：来自英国三项民族队列研究(重返南阿勒和布伦特)的发现
Rayan Anbar,Siana Jones,Nish Chaturvedi et al.
Rayan Anbar et al.
Background: Cognitive function has an important role in determining the quality of life of older adults. Cardiovascular disease (CVD) is common in older people and may compromise cognitive performance; however, the extent...
The atorvastatin metabolite pattern in muscle tissue and blood plasma is associated with statin muscle side effects in patients with coronary heart disease; An exploratory case-control study [0.03%]
肌肉组织和血浆中的阿托伐他汀代谢物模式与冠心病患者出现的他汀类药物肌不良反应有关；一项探索性的病例对照研究
Trine Lauritzen,John Munkhaugen,Stein Bergan et al.
Trine Lauritzen et al.
Background and aims: Statin-associated muscle symptoms (SAMS) is a prevalent cause of statin discontinuation. It is challenging and time-consuming for clinicians to assess whether symptoms are caused by the statin or not,...
Conditional deletion of Ccl2 in smooth muscle cells does not reduce early atherosclerosis in mice [0.03%]
平滑肌细胞中Ccl2的条件性删除并不能减少小鼠早期的动脉粥样硬化病变
Stine Gunnersen,Jeong Tangkjær Shim,Fan Liu et al.
Stine Gunnersen et al.
Background and aims: C-C motif chemokine ligand 2 (CCL2) is a pro-inflammatory chemokine important for monocyte recruitment to the arterial wall and atherosclerotic plaques. Global knockout of Ccl2 reduces plaque formatio...