The role and mechanism of PGC-1α in oxLDL-induced ferroptosis of vascular endothelial cells [0.03%]
PGC-1α在氧化型低密度脂蛋白诱导的血管内皮细胞铁死亡中的作用及机制研究
Jiao Li,Pingping He,Yu Zhang et al.
Jiao Li et al.
Ferroptosis is a regulated form of cell death that is dependent on reactive oxygen species (ROS) and iron metabolism. Ferroptosis can participate in the formation and rupture of atherosclerotic plaque by regulating apoptosis. However, the m...
Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways [0.03%]
茯苓sterol通过NF-κB和p38/Erk MAPK信号途径发挥抗动脉粥样硬化作用
Tiancheng Liu,Mengli Zhang,Xian Wu et al.
Tiancheng Liu et al.
Background: Fucosterol is a sterol isolated from brown algae and has various biological properties, such anti-inflammatory and antidiabetic effects. In this study, we investigated the anti-atherosclerosis effects of fucos...
Association of dietary preferences with cardiovascular disease: a Mendelian randomization study [0.03%]
饮食偏爱与心血管疾病的关系：一项孟德尔随机化研究
Mia D Lee,Benjamin F Voight
Mia D Lee
Background and aims: Susceptibility to cardiovascular disease (CVD) is driven by genetic and environmental risk factors. Diet is a modifiable and largely environmental risk factor for CVD. Genetic factors associated with ...
Plasma apolipoprotein concentrations and occurrence of cardiovascular events in the general population: an exploratory analysis [0.03%]
人群血浆载脂蛋白浓度与心血管事件的关联：一项探索性分析
Avedis Torossian,Annelise Genoux,Zichun Cai et al.
Avedis Torossian et al.
Background and aims: The role of many apolipoproteins in cardiovascular disease (CVD) pathophysiology and their predictive potential remains unclear. This study examined the association between plasma concentrations of a ...
Trends of atherosclerosis-related mortality in adults with diabetes: A cross-sectional analysis of U.S. national data [0.03%]
美国全国数据中糖尿病成人动脉粥样硬化相关死亡率趋势的横断面分析
Yusuf Hasan Ali,Fakhar Latif,Fatimah Hoda et al.
Yusuf Hasan Ali et al.
Background: Diabetes mellitus is a rapidly growing global health issue, projected to affect 643 million adults by 2030. Atherosclerosis, a prevalent complication of diabetes, significantly contributes to morbidity and mor...
ApoE [-/-] CA1-overexpressing knock-in mice aggravated atherosclerosis by increasing M1 macrophages [0.03%]
ApoE[-/-]CA1过表达敲入小鼠通过增加M1型巨噬细胞促进动脉粥样硬化发展
Jinbao Zong,Changyuan Wang,Hongji Zhou et al.
Jinbao Zong et al.
Background: Carbonic anhydrase I (CA1) has been reported to be a diagnostic and therapeutic target for atherosclerosis (AS). This study aimed to verify the essential role of CA1 in AS progression in CA1-overexpressing mic...
Real-world management of hypercholesterolemia in patients after acute coronary syndrome in Greece [0.03%]
希腊急性冠脉综合征患者血脂管理的现状及挑战：一项真实世界研究
Despoina Massia,Periklis Giovas,Nikolaos Papadopoulos et al.
Despoina Massia et al.
Background: Prompt initiation of lipid-lowering therapy (LLT) following acute coronary syndrome (ACS) is crucial for preventing secondary cardiovascular events. However, there are gaps in clinical implementation of the 20...
A male patient with pseudoxanthoma elasticum caused by isodisomy of chromosome 16 containing a nonsense variant of the ABCC6 gene: A quarter-century treatment experience [0.03%]
一条16号染色体均等分离导致ABCC6基因无义突变的假黄斑弹性组织炎(PXE)患者病例报告及25年治疗经验
Minoru Wakasa,Chihiro Nakagawa,Taka-Aki Takamura et al.
Minoru Wakasa et al.
Pseudoxanthoma elasticum (PXE) is a rare autosomal recessive disorder characterized by fragmentation and calcification of the elastic fibers of the skin, eyes, and various arteries with highly variable clinical expression. PXE is predominan...
HDL-replacement therapy: From traditional to emerging clinical applications [0.03%]
HDL替代疗法：从传统到新兴的临床应用
Cesare Riccardo Sirtori,Giulia Cincotto,Sofia Castiglione et al.
Cesare Riccardo Sirtori et al.
The unique and multifaceted properties of high-density lipoproteins (HDL)-ranging from cholesterol efflux to anti-inflammatory, anti-oxidant, and immunomodulatory effects-have prompted their direct use, particularly in cardiovascular ischem...
"Inclisiran: Early LDL-C target achievement in a real-life population" [0.03%]
"Inclisiran：真实人群中早期实现LDL-C目标"
Francesco Briani,Mauro Bagli,Gabriele Venturi et al.
Francesco Briani et al.
Background and objectives: Elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with atherosclerotic cardiovascular diseases. Inclisiran, a small interfering RNA, has been observed to effectively and...