Lipoprotein(a) and the atherosclerotic burden - Should we wait for clinical trial evidence before taking action? [0.03%]
脂蛋白(a)与动脉粥样硬化负担-临床试验证据之前是否应立即采取行动？
Isabella Fichtner,Chiara Macchi,Alessandra Stefania Rizzuto et al.
Isabella Fichtner et al.
The fact that lipoprotein(a) levels should be regarded as a causal residual risk factor in the atherosclerotic cardiovascular diseases (ASCVD) is now a no-brainer. This review article aims to summarize the latest evidence supporting the cau...
Coronary artery calcification score and 19 biomarkers on cardiovascular events; a 10-year follow-up DanRisk substudy [0.03%]
冠状动脉钙化评分与19种生物标志物对心血管事件的影响；DanRisk的10年随访子研究
Mie Schæffer,Jeppe Holm Rasmussen,Maise Høigaard Fredgart et al.
Mie Schæffer et al.
Aim: The SCORE2 algorithm is recommended to estimate risk of cardiovascular disease (CVD). Coronary artery calcification (CAC) score is expensive but improves the risk prediction. This study aims to determine and compare ...
Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes [0.03%]
急性冠脉综合征后海洋ω-3脂肪酸补充剂的使用指征
Cédric Follonier,Gabriel Rabassa,Mattia Branca et al.
Cédric Follonier et al.
Background and aims: The 2019 European Society of Cardiology guidelines for the management of dyslipidemia consider the use of high-dose marine omega-3 fatty acid (FA) eicosapentaenoic acid (EPA) supplementation (icosapen...
The pro-atherogenic enzyme PAPP-A is active in eluates from human carotid and femoral atherosclerotic plaques [0.03%]
人颈动脉和股动脉粥样硬化斑块洗脱液中促动脉粥样硬化的PAPP-A酶活跃
Mette Faurholdt Gude,Rikke Hjortebjerg,Mette Bjerre et al.
Mette Faurholdt Gude et al.
Background: Pregnancy-associated plasma protein-A (PAPP-A) regulates bioavailability of insulin-like growth factor 1 (IGF1) in various tissues by proteolytic cleavage of a subset of IGF-binding proteins (IGFBPs). Pre-clin...
Extreme founder effect associated with hyperglycemia and hyperlipidemia on the island of NIAS/Indonesia [0.03%]
尼西亚岛/印度尼西亚极端奠基者效应与高血糖和高脂血症的相关性研究
Ingo Kennerknecht,Johannes M Hämmerle,Manfred Fobker et al.
Ingo Kennerknecht et al.
The island of Nias/Indonesia shows an extremely reduced genetic diversity indicating a strong founder effect. As a consequence, the prevalence of some disease genes should significantly differ among populations depending on the gene pool pa...
Associations of very low Lipoprotein(a) levels with risks of new-onset diabetes and non-alcoholic liver disease [0.03%]
极低脂蛋白(a)水平与新发糖尿病和非酒精性肝病风险的关系
Ming Wai Yeung,M Abdullah Said,Yordi J van de Vegte et al.
Ming Wai Yeung et al.
Background and aims: We aimed to study the association of very low serum Lipoprotein(a) [Lp(a)] concentrations with new-onset type 2 diabetes (T2D) and non-alcoholic liver disease (NAFLD) in the context of statin usage in...
Lipoprotein(a) in children and adolescents with genetically confirmed familial hypercholesterolemia followed up at a specialized lipid clinic [0.03%]
在专门的脂质诊所随访的遗传学确诊家族性高胆固醇血症儿童和青少年中的Lp(a)
Anja K Johansen,Martin P Bogsrud,Magne Thoresen et al.
Anja K Johansen et al.
Background and aim: Many children with an FH mutation also exhibit elevated lipoprotein(a) levels, which is an independent risk factor for atherosclerotic cardiovascular disease. Studies have reported higher levels of lip...
Chongxu Shi,Zhaozhi Wen,Yihang Yang et al.
Chongxu Shi et al.
Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death wo...
Trends in cardiovascular disease among Inuit in Greenland from 1994 to 2021 [0.03%]
1994年至2021年格陵兰因纽特人心血管疾病流行趋势
Hjalte Erichsen Larsen,Uka Wilhjelm Geisler,Finn Gustafsson et al.
Hjalte Erichsen Larsen et al.
Background and aims: Cardiovascular disease (CVD) poses significant health challenges globally. While substantial data exists for most populations, the Arctic Inuit's CVD incidence rates remain understudied. This research...
Carotid intima-medial thickness in patients with severe hypertriglyceridemia [0.03%]
严重高甘油三酯血症患者的颈动脉中膜厚度变化
Maud Ahmad,Brooke A Kennedy,Surim Son et al.
Maud Ahmad et al.
Background and aims: Severe hypertriglyceridemia (HTG), defined as plasma triglyceride (TG) concentration > 10 mmol/L, is relatively uncommon, and its implications for atherosclerotic cardiovascular disease (ASCVD) risk r...