Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9 [0.03%]
针对血脂代谢和炎症的天然抗动脉粥样硬化化合物：重点研究PPAR、LXR和PCSK9
Marcella Palumbo,Martina Ugolotti,Francesca Zimetti et al.
Marcella Palumbo et al.
A large body of evidence has shown that modulation of the nuclear receptors peroxisome proliferator-activated receptors (PPARs), the liver X receptors (LXRs), the proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammatory proces...
HDL-associated vitamin D binding protein levels are inversely associated with necrotic plaque burden in psoriasis [0.03%]
银屑病患者hdl相关维生素d结合蛋白水平与坏死斑块负荷量呈负相关性
M P Playford,H Li,A K Dey et al.
M P Playford et al.
Background and aims: Vitamin D binding protein (DBP) serves a dual function as a vitamin D carrier and actin scavenger. Free DBP is present in high concentrations in serum, while a smaller pool is bound to lipoproteins li...
Familial hypercholesterolemia - Targeted whole gene sequencing as a diagnostic approach [0.03%]
家族性高胆固醇血症-作为诊断手段的靶向完整基因序列分析
Emma Adolfsson,Nils Johan Fredriksson,Jon Jonasson et al.
Emma Adolfsson et al.
Background and aims: Familial hypercholesterolemia (FH) and other disorders with similar features are common genetic disorders that remain underdiagnosed and undertreated, due in part to the cost of screening. The aim of ...
Impact of NAFLD-related SNPs on the carotid atherosclerosis development; a five-year prospective observational study [0.03%]
非酒精性脂肪肝相关遗传位点对颈动脉粥样硬化发生发展影响的前瞻性研究
Hiroaki Ikezaki,Ryoko Nakashima,Yuji Matsumoto et al.
Hiroaki Ikezaki et al.
Background and aims: The prevalence of metabolic dysfunction associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), has become a significant public health concern with an i...
Nicola Ferri,Giorgia Marodin
Nicola Ferri
Pharmacological inhibition of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) have been firmly established to be an effective approach to reduce low-density lipoprotein (LDL) cholesterol levels and cardiovascular events. Subcutaneous admin...
A cross-tissue transcriptome-wide association study identifies WDPCP as a potential susceptibility gene for coronary atherosclerosis [0.03%]
横断面转录组关联研究确定WDPCP是冠状动脉粥样硬化的潜在易感基因
Xinyue Hu,Guanglei Chen,Xiaofang Yang et al.
Xinyue Hu et al.
Background: Coronary atherosclerosis (CAS) is a complex chronic inflammatory disease with significant genetic and environmental contributions. While genome-wide association studies (GWAS) have pinpointed many risk loci, o...
Real-world data lipid profiles in one million colombian adults: The LiPAC million person study [0.03%]
一百万哥伦比亚成年人的现实世界血脂谱特征——LiPAC百万研究项目
Claudia C Colmenares-Mejía,Marcela Godoy-Corredor,Esteban Morales-Mendoza et al.
Claudia C Colmenares-Mejía et al.
Background and aims: Lipid profile results are of clinical interest for assessing the presence of dyslipidemia and the risk of cardiovascular disease. This study aimed to characterize lipid profile parameters in a large a...
A collaborative effort across Africa to investigate risk factors and outcomes of premature acute coronary syndrome: Protocol for the EAS Lipid Registry of Africa (LIPRA) [0.03%]
非洲早期急性冠脉综合征风险因素及预后的大规模合作研究项目——非洲动脉硬化学会血脂登记注册（LIPRA）项目方案
Ashraf Reda,Alexander R M Lyons,Alberto Zambon et al.
Ashraf Reda et al.
Data on acute coronary syndrome (ACS) is lacking in Africa where cases of premature ACS seem to be on the rise. Africa would benefit from an epidemiological assessment of premature ACS to determine its risk factors and management in this de...
Adherence to the Healthy Nordic Food Index is associated with reduced plasma levels of inflammatory markers in patients with heterozygous familial hypercholesterolemia [0.03%]
健康北欧饮食指数依从性与杂合子家族高胆固醇血症患者炎症标志物的血浆水平降低相关
Eirin B Løvheim,Kjetil Retterstøl,Ingunn Narverud et al.
Eirin B Løvheim et al.
Background and aims: Familial hypercholesterolemia (FH) is an inherited disease associated with hypercholesterolemia, and dietary treatment is part of the treatment. We aimed to assess the dietary pattern in relation to t...
Efficacy and safety of lipid-lowering therapies in combination with or without statin to reduce the cardiovascular risk: A systematic review of randomised controlled trials [0.03%]
非他汀类降脂疗法与他汀类药物联合或单药治疗降低心血管风险的有效性和安全性：系统评价和 meta 分析
Gabriella Iannuzzo,Geetank Kamboj,Parinita Barman et al.
Gabriella Iannuzzo et al.
Background and aims: Cardiovascular diseases (CVD) pose a significant global health burden. Lowering low-density lipoprotein-cholesterol is the primary therapeutic aim for preventing primary and secondary CVD events. Whil...