Trends of atherosclerosis-related mortality in adults with diabetes: A cross-sectional analysis of U.S. national data [0.03%]
美国全国数据中糖尿病成人动脉粥样硬化相关死亡率趋势的横断面分析
Yusuf Hasan Ali,Fakhar Latif,Fatimah Hoda et al.
Yusuf Hasan Ali et al.
Background: Diabetes mellitus is a rapidly growing global health issue, projected to affect 643 million adults by 2030. Atherosclerosis, a prevalent complication of diabetes, significantly contributes to morbidity and mor...
ApoE [-/-] CA1-overexpressing knock-in mice aggravated atherosclerosis by increasing M1 macrophages [0.03%]
ApoE[-/-]CA1过表达敲入小鼠通过增加M1型巨噬细胞促进动脉粥样硬化发展
Jinbao Zong,Changyuan Wang,Hongji Zhou et al.
Jinbao Zong et al.
Background: Carbonic anhydrase I (CA1) has been reported to be a diagnostic and therapeutic target for atherosclerosis (AS). This study aimed to verify the essential role of CA1 in AS progression in CA1-overexpressing mic...
Real-world management of hypercholesterolemia in patients after acute coronary syndrome in Greece [0.03%]
希腊急性冠脉综合征患者血脂管理的现状及挑战：一项真实世界研究
Despoina Massia,Periklis Giovas,Nikolaos Papadopoulos et al.
Despoina Massia et al.
Background: Prompt initiation of lipid-lowering therapy (LLT) following acute coronary syndrome (ACS) is crucial for preventing secondary cardiovascular events. However, there are gaps in clinical implementation of the 20...
A male patient with pseudoxanthoma elasticum caused by isodisomy of chromosome 16 containing a nonsense variant of the ABCC6 gene: A quarter-century treatment experience [0.03%]
一条16号染色体均等分离导致ABCC6基因无义突变的假黄斑弹性组织炎(PXE)患者病例报告及25年治疗经验
Minoru Wakasa,Chihiro Nakagawa,Taka-Aki Takamura et al.
Minoru Wakasa et al.
Pseudoxanthoma elasticum (PXE) is a rare autosomal recessive disorder characterized by fragmentation and calcification of the elastic fibers of the skin, eyes, and various arteries with highly variable clinical expression. PXE is predominan...
HDL-replacement therapy: From traditional to emerging clinical applications [0.03%]
HDL替代疗法：从传统到新兴的临床应用
Cesare Riccardo Sirtori,Giulia Cincotto,Sofia Castiglione et al.
Cesare Riccardo Sirtori et al.
The unique and multifaceted properties of high-density lipoproteins (HDL)-ranging from cholesterol efflux to anti-inflammatory, anti-oxidant, and immunomodulatory effects-have prompted their direct use, particularly in cardiovascular ischem...
"Inclisiran: Early LDL-C target achievement in a real-life population" [0.03%]
"Inclisiran：真实人群中早期实现LDL-C目标"
Francesco Briani,Mauro Bagli,Gabriele Venturi et al.
Francesco Briani et al.
Background and objectives: Elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with atherosclerotic cardiovascular diseases. Inclisiran, a small interfering RNA, has been observed to effectively and...
Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model [0.03%]
生物可吸收聚合物依维莫司洗脱支架植入后使用埃多沙班单药治疗的安全性和有效性研究——基于猪的类似人类冠状动脉粥样硬化模型
Daisuke Kitano,Suguru Migita,Yuxin Li et al.
Daisuke Kitano et al.
Background: The combination of antiplatelet and antithrombotic drugs increases the risk of bleeding in patients with atrial fibrillation after coronary drug-eluting stent (DES) implantation. However, the appropriateness o...
Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9 [0.03%]
针对血脂代谢和炎症的天然抗动脉粥样硬化化合物：重点研究PPAR、LXR和PCSK9
Marcella Palumbo,Martina Ugolotti,Francesca Zimetti et al.
Marcella Palumbo et al.
A large body of evidence has shown that modulation of the nuclear receptors peroxisome proliferator-activated receptors (PPARs), the liver X receptors (LXRs), the proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammatory proces...
HDL-associated vitamin D binding protein levels are inversely associated with necrotic plaque burden in psoriasis [0.03%]
银屑病患者hdl相关维生素d结合蛋白水平与坏死斑块负荷量呈负相关性
M P Playford,H Li,A K Dey et al.
M P Playford et al.
Background and aims: Vitamin D binding protein (DBP) serves a dual function as a vitamin D carrier and actin scavenger. Free DBP is present in high concentrations in serum, while a smaller pool is bound to lipoproteins li...
Familial hypercholesterolemia - Targeted whole gene sequencing as a diagnostic approach [0.03%]
家族性高胆固醇血症-作为诊断手段的靶向完整基因序列分析
Emma Adolfsson,Nils Johan Fredriksson,Jon Jonasson et al.
Emma Adolfsson et al.
Background and aims: Familial hypercholesterolemia (FH) and other disorders with similar features are common genetic disorders that remain underdiagnosed and undertreated, due in part to the cost of screening. The aim of ...