Poecilobdella manillensis ameliorates atherosclerosis by inhibiting endothelial cell pyroptosis [0.03%]
.POECILOBDELLA MANILLENSIS通过抑制血管内皮细胞焦亡改善动脉粥样硬化
Chunxia Guo,Yudong Rao,Hao Zhou et al.
Chunxia Guo et al.
Objective: Leeches and other herbs may improve atherosclerosis symptoms. This study explores Poecilobdella manillensis'effect on AS. Methods: ...
Innate immune cell function in statin-treated patients with severe hypercholesterolemia is comparable to normocholesterolemic individuals: A cross-sectional study [0.03%]
他汀类药物治疗的重度高胆固醇血症患者与正常胆固醇水平个体的固有免疫细胞功能可比：横断面研究
Harsh Bahrar,Kim Steward,Liesbeth van Emst et al.
Harsh Bahrar et al.
Background and aims: Hypercholesterolemia is a major risk factor for atherosclerotic cardiovascular disease. Innate immune cells, including monocytes and neutrophils, play important roles in the pathophysiology of atheros...
Takafumi Mito,Daisuke Kinoshita,Yoichiro Otaki et al.
Takafumi Mito et al.
Background: Plaque disruption exposes thrombogenic substrates and triggers local thrombosis. When a fresh thrombus forms, endogenous antithrombotic mechanisms activate. The balance between these two pro- and antithromboti...
Neural network model outperforms conventional equations in LDL cholesterol estimation: A comparative study of 188,887 Chinese individuals with focus on hypertriglyceridemia [0.03%]
神经网络模型在LDL胆固醇估算中优于传统公式：针对高甘油三酯血症的188,887名中国人的比较研究
Hao Xue,Yu Lin,Youlin Liu et al.
Hao Xue et al.
Background: Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is crucial for atherosclerotic cardiovascular disease (ASCVD) risk management. Extensive international validation studies have demonstrated th...
Characterization of selected LDLR substitutions in patients with familial hypercholesterolemia [0.03%]
家族性高胆固醇血症患者中选LDLR改变的特征分析
Monika Targońska,Anna Janaszak-Jasiecka,Magdalena Chmara et al.
Monika Targońska et al.
Background and aims: Familial hypercholesterolemia is a genetic disorder caused by pathogenic or likely pathogenic variants in four key genes: LDLR, APOB, PCSK9, and APOE. It leads to elevated levels of low-density lipopr...
Earthworm fibrinolytic enzyme A and fibrin-derived peptide Bβ15-42 attenuate atherosclerosis via the VE-Cadherin signaling pathway [0.03%]
蚯蚓纤溶酶A和由纤溶酶降解纤维蛋白产生的Bβ15-42肽通过VE-钙黏着蛋白信号通路抗动脉粥样硬化作用研究
Xiaowei Yin,Yajie Zhang,Luyao Shi et al.
Xiaowei Yin et al.
Aim: Earthworm fibrinolytic enzymes A (EFEa) is the main active component of earthworm fibrinolytic enzymes which possesses anticoagulant, fibrinolytic, and potential anti-atherosclerotic effects. However, the biological ...
Midlife ICAM-1 levels may predict cardiovascular disease and cognitive decline in latelife: Insights from the HeartSCORE study [0.03%]
中年时期的ICAM-1水平可能是晚年心血管疾病和认知能力下降的预测指标：来自HeartSCORE研究的启示
Khaled Abdoun,Justin Swanson,Ian Pollack et al.
Khaled Abdoun et al.
Introduction: Systemic inflammation is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD) and has also been implicated in the progression of neuroinflammation. However, the relationship betw...
Inclisiran for fast-track lipid-lowering treatment early after an acute coronary syndrome: a pilot study [0.03%]
急性冠脉综合征后早期迅速降脂治疗的inclisiran试点研究
Alessandro Lupi,Martino Baluci,Simone Persampieri et al.
Alessandro Lupi et al.
Background: Elevated low-density lipoprotein cholesterol (LDL-C) after acute coronary syndrome (ACS) significantly increases cardiovascular risk. Timely reduction of LDL-C is crucial, but it takes several weeks to achieve...
Monocytes from people with Familial Hypercholesterolaemia are inflammatory, despite statin-treatment [0.03%]
他汀治疗不能改变家族性高胆固醇血症患者单核细胞的炎症表型
Helen Williams,Habib Francis,Jasmin Huang et al.
Helen Williams et al.
Background and aims: Familial Hypercholesterolaemia (FH) is characterised by high cholesterol and premature cardiovascular disease. While hypercholesterolaemia and inflammation are both key drivers in the formation of ath...
Inclisiran in a real-world single-center registry of patients with very high atherosclerotic cardiovascular risk [0.03%]
依折麦布在极高动脉粥样硬化性心血管风险患者中的真实世界单中心注册研究
Antonio Centola,Michelangelo Carbonara,Serena De Nuzzo et al.
Antonio Centola et al.
Background: A mean relative 50 % reduction of LDL cholesterol (LDLc) levels was observed in randomized studies in patients treated with inclisiran, a small-interfering-RNA therapeutic agent that reduces hepatic synthesis ...