Sex-specific associations of the triglyceride-glucose index with systemic inflammation and arterial stiffness in adults with normal glucose and triglyceride levels [0.03%]
空腹血糖和甘油三酯正常成年人动脉僵硬及系统性炎症的性别差异及相关性研究——基于TG×GL指数的作用探讨
Wei-Chen Shen,Hung-Yu Chen,I-Hsuan Wu et al.
Wei-Chen Shen et al.
Background: The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance. However, its clinical relevance in individuals with strictly normal fasting glucose and triglyceride levels remains unclear. We...
Associations of lipoprotein(a) concentrations with cardiovascular disease in men and women with primary hypercholesterolemia [0.03%]
Lp(a)与原发性高胆固醇血症男、女性心血管疾病的关系分析
Jakub Kurdziel,Andrzej Fedak,Agnieszka Micek et al.
Jakub Kurdziel et al.
Lipoprotein(a) [Lp(a)] is a useful marker for cardiovascular risk stratification. Previous studies have shown higher Lp(a) levels in women than in men and sex differences in its association with atherosclerosis. The aim of this study was to...
Systematic literature review on the real-world effectiveness and safety of bempedoic acid [0.03%]
贝迈普渡酸真实世界疗效和安全性的系统评价研究
Arrigo Francesco Giuseppe Cicero,Christopher P Cannon,Raju Gautam et al.
Arrigo Francesco Giuseppe Cicero et al.
Background and aims: Cardiovascular disease remains a significant global health burden. Bempedoic acid is a novel, oral adenosine triphosphate-citrate lyase inhibitor that lowers low-density lipoprotein cholesterol (LDL-C...
CNN3 promotes vascular smooth muscle cells proliferation and migration to deteriorate atherosclerosis by β-catenin signaling pathway [0.03%]
CNN3通过β-连环素信号通路促进血管平滑肌细胞增殖和迁移从而恶化动脉粥样硬化病变
Ru-Yi Zhang,Chang-Meng Wu,Juan-Jiang Chen et al.
Ru-Yi Zhang et al.
Atherosclerosis (AS) is a complex pathophysiological process. Evidence has demonstrated that abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) play an essential role in AS. Calponin 3 (CNN3) is implicated in the p...
Calciprotein particles disrupt autophagy in vascular endothelial cells and smooth muscle cells [0.03%]
钙蛋白颗粒通过破坏血管内皮细胞和血管平滑肌细胞自噬过程促进血管钙化
Negar Sharifimoghaddammood,Isabel Pintelon,Winnok H De Vos et al.
Negar Sharifimoghaddammood et al.
Calciprotein particles (CPPs) act as buffers against mineral overload, but during prolonged mineral stress they convert from the small, amorphous CPP1 form into large, crystalline CPP2. This shift is associated with endothelial dysfunction ...
Association between HIV infection and arterial stiffness: A population-based cross-sectional study from Rakai, South Western Uganda [0.03%]
HIV感染与动脉硬化关系的基于人群的横断面研究：来自乌干达拉卡伊西部的研究
Charles Batte,Martha Sarah Namusobya,Shivan Nuwasiima et al.
Charles Batte et al.
Image 1. Keywords: Arterial stiffness; HIV; Pulse wave velocity; Sub-saharan africa. ©...
Plasma-derived small extracellular vesicle miR-660-5p as a predictor for carotid plaque vulnerability and postoperative major adverse cardiovascular event risk [0.03%]
血浆源性小细胞外囊泡miR-660-5p预测颈动脉斑块不稳定性及术后主要心血管不良事件风险的研究
Xin Xu,Taoyuan Lu,Dechao Wang et al.
Xin Xu et al.
Background: Building on our previous isolation of plaque-derived small extracellular vesicles (sEVs) from carotid atherosclerotic stenosis (CAS) patients, this study aimed to identify plasma sEV-encapsulated miRNAs that r...
Proprotein convertase subtilisin/kexin type 9-CC-motif chemokine ligand 2 interactions link lipoprotein(a) composition to intermediate monocyte inflammation in coronary artery disease [0.03%]
蛋白质转化酶枯草杆菌蛋白酶/kexin亚型9与CC基序细胞因子配体2的相互作用将冠状动脉疾病中脂蛋白（a）的组成连接到单核细胞介导的中间炎症反应
Sabina Ugovšek,Andreja Rehberger Likozar,Tina Levstek et al.
Sabina Ugovšek et al.
Background: Intermediate monocytes (IM) exhibit proinflammatory properties and contribute to atherosclerosis. Elevated lipoprotein(a) [Lp(a)] levels modulate monocyte behavior, while proprotein convertase subtilisin/kexin...
Associations of NMR metabolic biomarkers and arterial calcification: An observational and Mendelian randomization study within the BBMRI metabolomics consortium [0.03%]
基于BBMRI代谢组学联盟的磁共振代谢生物标志物与动脉钙化的关联性观察及孟德尔随机化研究
Haojie Lu,Maxime M Bos,Nicolien A van Vliet et al.
Haojie Lu et al.
Background and aim: The metabolic roles in arterial calcification remain largely unclear. We aimed to elucidate the associations between nuclear magnetic resonance (NMR) metabolic biomarkers with site- and sex-specific ar...
PCSK9 in vascular smooth muscle cells: biology, pathology, and inhibition to fight atherosclerosis [0.03%]
血管平滑肌细胞中的PCSK9：生物学、病理学及其抑制作用对抗动脉粥样硬化
Alessio Amorosi,Mathilde Varret
Alessio Amorosi
Atherosclerosis remains the principal cause of cardiovascular morbidity and mortality worldwide, with vascular smooth muscle cells (VSMC) serving as central effectors in plaque initiation, progression, and destabilization. Although original...