Neural network model outperforms conventional equations in LDL cholesterol estimation: A comparative study of 188,887 Chinese individuals with focus on hypertriglyceridemia [0.03%]
神经网络模型在LDL胆固醇估算中优于传统公式：针对高甘油三酯血症的188,887名中国人的比较研究
Hao Xue,Yu Lin,Youlin Liu et al.
Hao Xue et al.
Background: Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is crucial for atherosclerotic cardiovascular disease (ASCVD) risk management. Extensive international validation studies have demonstrated th...
Characterization of selected LDLR substitutions in patients with familial hypercholesterolemia [0.03%]
家族性高胆固醇血症患者中选LDLR改变的特征分析
Monika Targońska,Anna Janaszak-Jasiecka,Magdalena Chmara et al.
Monika Targońska et al.
Background and aims: Familial hypercholesterolemia is a genetic disorder caused by pathogenic or likely pathogenic variants in four key genes: LDLR, APOB, PCSK9, and APOE. It leads to elevated levels of low-density lipopr...
Earthworm fibrinolytic enzyme A and fibrin-derived peptide Bβ15-42 attenuate atherosclerosis via the VE-Cadherin signaling pathway [0.03%]
蚯蚓纤溶酶A和由纤溶酶降解纤维蛋白产生的Bβ15-42肽通过VE-钙黏着蛋白信号通路抗动脉粥样硬化作用研究
Xiaowei Yin,Yajie Zhang,Luyao Shi et al.
Xiaowei Yin et al.
Aim: Earthworm fibrinolytic enzymes A (EFEa) is the main active component of earthworm fibrinolytic enzymes which possesses anticoagulant, fibrinolytic, and potential anti-atherosclerotic effects. However, the biological ...
Midlife ICAM-1 levels may predict cardiovascular disease and cognitive decline in latelife: Insights from the HeartSCORE study [0.03%]
中年时期的ICAM-1水平可能是晚年心血管疾病和认知能力下降的预测指标：来自HeartSCORE研究的启示
Khaled Abdoun,Justin Swanson,Ian Pollack et al.
Khaled Abdoun et al.
Introduction: Systemic inflammation is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD) and has also been implicated in the progression of neuroinflammation. However, the relationship betw...
Inclisiran for fast-track lipid-lowering treatment early after an acute coronary syndrome: a pilot study [0.03%]
急性冠脉综合征后早期迅速降脂治疗的inclisiran试点研究
Alessandro Lupi,Martino Baluci,Simone Persampieri et al.
Alessandro Lupi et al.
Background: Elevated low-density lipoprotein cholesterol (LDL-C) after acute coronary syndrome (ACS) significantly increases cardiovascular risk. Timely reduction of LDL-C is crucial, but it takes several weeks to achieve...
Monocytes from people with Familial Hypercholesterolaemia are inflammatory, despite statin-treatment [0.03%]
他汀治疗不能改变家族性高胆固醇血症患者单核细胞的炎症表型
Helen Williams,Habib Francis,Jasmin Huang et al.
Helen Williams et al.
Background and aims: Familial Hypercholesterolaemia (FH) is characterised by high cholesterol and premature cardiovascular disease. While hypercholesterolaemia and inflammation are both key drivers in the formation of ath...
Inclisiran in a real-world single-center registry of patients with very high atherosclerotic cardiovascular risk [0.03%]
依折麦布在极高动脉粥样硬化性心血管风险患者中的真实世界单中心注册研究
Antonio Centola,Michelangelo Carbonara,Serena De Nuzzo et al.
Antonio Centola et al.
Background: A mean relative 50 % reduction of LDL cholesterol (LDLc) levels was observed in randomized studies in patients treated with inclisiran, a small-interfering-RNA therapeutic agent that reduces hepatic synthesis ...
Demographic and regional trends of mortality in patients with cardiovascular disease and liver cirrhosis in the United States between 1999 and 2019 [0.03%]
1999至2019年美国心血管疾病合并肝硬化患者的死亡率地区和人口统计学变化趋势
Farah Yasmin,Abdul Moeed,Muhammad Ahmed Ali Fahim et al.
Farah Yasmin et al.
Objectives: National estimates of deaths related to cardiovascular disease (CVD) and liver cirrhosis remain ambiguous. The purpose of this study was to observe the contemporary trends in CVD and liver cirrhosis-related mo...
Effect of lipid-lowering medications on oxidized phospholipids in individuals with elevated LIPOPROTEIN(a) [0.03%]
他汀类和依折麦布对血脂影响研究中的氧化磷脂变化特征分析
Amalia Despoina Koutsogianni,Fotios Barkas,Constantinos Tellis et al.
Amalia Despoina Koutsogianni et al.
Background/introduction: Oxidized phospholipids (OxPLs) are bound to apolipoprotein B-100 (OxPL-apoB) and apolipoprotein(a) [OxPL-apo(a)] and are present freely within the phospholipid shell of apoB-containing lipoprotein...
The association between dolutegravir based first-line antiretroviral regimens and dyslipidemia among adults living with HIV on follow-up at health facilities in Hawassa city administration, Sidama region: a cross-sectional study [0.03%]
基于多替拉韦的第一线抗逆转录病毒治疗与霍瓦萨市HIV感染成年人血脂异常之间的关联：横断面研究
Agete Tadewos Hirigo,Alemayehu Abera,Daniel Yilma et al.
Agete Tadewos Hirigo et al.
Background: Inconsistent evidence on lipid alterations in people living with HIV (PLWH) on dolutegravir (DTG)-based antiretroviral therapy (ART) highlights the need for further study. This study aimed to assess the associ...