Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile [0.03%]
Lomitapide不对纯合子家族性高胆固醇血症患者的PCSK9和Lp(a)水平产生影响：细胞因子和血脂谱的分析
Maria Giovanna Lupo,Diletta Arcidiacono,Alice Zaramella et al.
Maria Giovanna Lupo et al.
Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators w...
Differential association of flow velocities in the carotid artery with plaques, intima media thickness and cardiac function [0.03%]
颈动脉血流速度与斑块、内中膜厚度和心脏功能的差异化关联分析
David Leander Rimmele,Katrin Borof,Jan-Per Wenzel et al.
David Leander Rimmele et al.
Background and aims: We aimed to determine the association of carotid intima media thickness (CIMT), carotid plaques, and heart function with peak systolic velocity (PSV) of the common (CCA) and internal carotid artery (I...
Utilization of IVUS improves all-cause mortality in patients undergoing invasive coronary angiography [0.03%]
利用IVUS可改善进行有创冠状动脉造影患者的全因死亡率
Iryna Dykun,Olga Babinets,Stefanie Hendricks et al.
Iryna Dykun et al.
Background and aims: Available data suggest that the use of IVUS for guidance of percutaneous coronary interventions (PCIs) improves the prognosis of patients undergoing complex interventions. We aimed to examine how the ...
Polygenic risk score for hypercholesterolemia in a Brazilian familial hypercholesterolemia cohort [0.03%]
巴西型家族性高胆固醇血症队列的高胆固醇多基因风险评分
Isabella Ramos Lima,Mauricio Teruo Tada,Theo G M Oliveira et al.
Isabella Ramos Lima et al.
Background and aims: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of LDL-C leading to premature cardiovascular disease (CAD). Only about 40% of individuals with a clinical diagnosi...
Estimated cardiovascular benefits of bempedoic acid in patients with established cardiovascular disease [0.03%]
班瑞酸对已有心血管疾病的患者心血管获益的评估
Laura H Gunn,Ailsa J McKay,Amy Feng et al.
Laura H Gunn et al.
Background and aims: Cardiovascular outcomes trials have demonstrated that lowering low-density lipoprotein cholesterol (LDL-C) reduces the risk for future cardiovascular events. We assessed the potential cardiovascular b...
Two novel variants in the lecithin:cholesterol acyltransferase gene resulted in classic LCAT deficiency [0.03%]
卵磷脂：胆固醇酰基转移酶基因中的两种新变异导致典型的LCAT缺乏症
Margareta Fistrek Prlic,Marijana Coric,Laura Calabresi et al.
Margareta Fistrek Prlic et al.
Background and aims: We report the first two cases of familial lecithin:cholesterol acyltransferase (LCAT) deficiency in Croatia with classical clinical and biochemical features. ...
A PCSK9 inhibitor induces a transient decrease in the neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in homozygous familial hypercholesterolemia patients [0.03%]
PCSK9抑制剂可使纯合子家族性高胆固醇血症患者的中性粒细胞淋巴细胞比率和单核细胞淋巴细胞比率出现一过性下降
Fangyuan Li,Pucong Ye,Yu Hao et al.
Fangyuan Li et al.
Background and aims: Extremely elevated levels of low-density lipoprotein-cholesterol (LDL-C) contribute to long-term chronic systemic inflammation in homozygous familial hypercholesterolemia (HoFH) patients. The aims of ...
Semaglutide treatment attenuates vessel remodelling in ApoE-/- mice following vascular injury and blood flow perturbation [0.03%]
血管扰动和血液流动异常导致ApoE基因敲除小鼠血管病变，司美格鲁肽治疗对其有缓解作用
Ditte Marie Jensen,Gry Freja Skovsted,Mathilde Frederikke Bjørn Bonde et al.
Ditte Marie Jensen et al.
Background and aims: Randomized clinical studies have shown a reduction in cardiovascular outcomes with glucagon-like peptide 1 receptor agonist (GLP-1RA) treatment with the hypothesized mechanisms being an underlying eff...
Novel protein-truncating variant in the APOB gene may protect from coronary artery disease and adverse cardiovascular events [0.03%]
APOB基因中的新型蛋白质截短变异体可预防冠状动脉疾病和不利的心血管事件
Gabriele Mango,Nicola Osti,Silvia Udali et al.
Gabriele Mango et al.
Background and aims: Genetic testing is still rarely used for the diagnosis of dyslipidemia, even though gene variants determining plasma lipids levels are not uncommon. ...