Development of a digital amplifier system for cut-open oocyte electrophysiology [0.03%]
一种用于切割卵母细胞电生理学的数字放大器系统的开发研究
Lucas J Koerner,Ian Delgadillo Bonequi,Ian S K Shogren et al.
Lucas J Koerner et al.
The cut-open oocyte Vaseline gap technique is a powerful electrophysiological method for the characterization of ion channels. However, traditional amplifiers for cut-open oocyte Vaseline gap are labor intensive and require significant user...
Structural studies of the human α1 glycine receptor via site-specific chemical cross-linking coupled with mass spectrometry [0.03%]
位点特异性化学交联质谱法研究人类α1甘氨酸受体的结构属性
Rathna J Veeramachaneni,Chelsee A Donelan,Kayce A Tomcho et al.
Rathna J Veeramachaneni et al.
By identifying distance constraints, chemical cross-linking coupled with mass spectrometry (CX-MS) can be a powerful complementary technique to other structural methods by interrogating macromolecular protein complexes under native-like con...
Expression level of cardiac ryanodine receptors dictates properties of Ca2+-induced Ca2+ release [0.03%]
心脏ryanodine受体的表达水平决定了Ca2+诱导的Ca2+释放的性质
Roman Nikolaienko,Elisa Bovo,Aleksey V Zima
Roman Nikolaienko
The type 2 ryanodine receptor (RyR2) is the major Ca2+ release channel required for Ca2+-induced Ca2+ release (CICR) and cardiac excitation-contraction coupling. The cluster organization of RyR2 at the dyad is critical for efficient CICR. D...
An effective drift-diffusion model for pandemic propagation and uncertainty prediction [0.03%]
一种有效的漂移-扩散模型用于大流行传播和不确定性预测
Clara Bender,Abhimanyu Ghosh,Hamed Vakili et al.
Clara Bender et al.
Predicting pandemic evolution involves complex modeling challenges, typically involving detailed discrete mathematics executed on large volumes of epidemiological data. Making them physics based provides added intuition as well as predictiv...
Andrew McMahon,Swetha Vijayakrishnan,Hafez El Sayyed et al.
Andrew McMahon et al.
Many viruses are pleomorphic in shape and size, with pleomorphism often thought to correlate with infectivity, pathogenicity, or virus survival. For example, influenza and respiratory syncytial virus particles range in size from small spher...
Growing bacterial colonies harness emergent genealogical demixing to regulate organizational entropy [0.03%]
细菌群落利用系谱分相来调节组织熵增加
Garima Rani,Anupam Sengupta
Garima Rani
Spatiotemporal organization of individuals within growing bacterial colonies is a key determinant of intraspecific interactions and colony-scale heterogeneities. The evolving cellular distribution, in relation to the genealogical lineage, i...
Lipid loss and compositional change during preparation of simple two-component liposomes [0.03%]
简单双组分脂质体制备过程中脂类的损失与组成变化
Eunice Kim,Olivia Graceffa,Rachel Broweleit et al.
Eunice Kim et al.
Liposomes are used as model membranes in many scientific fields. Various methods exist to prepare liposomes, but common procedures include thin-film hydration followed by extrusion, freeze-thaw, and/or sonication. These procedures can produ...
Joshua L Botha,Bertus van Heerden,Tjaart P J Krüger
Joshua L Botha
We present Full SMS, a multipurpose graphical user interface (GUI)-based software package for analyzing single-molecule spectroscopy (SMS) data. SMS typically delivers multiparameter data-such as fluorescence brightness, lifetime, and spect...
Ivan V Prikhodko,Georgy Th Guria
Ivan V Prikhodko
The effectiveness of antitumor chimeric antigen receptor (CAR) therapy mainly dealt with an elevated sensitivity of CAR cells to target cells. However, CAR therapies are associated with nonspecific side effects: on-target off-tumor toxicity...
Niranjan Sarpangala,Brooke Randell,Ajay Gopinathan et al.
Niranjan Sarpangala et al.
A common type of cytoskeletal morphology involves multiple microtubules converging with their minus ends at the microtubule organizing center (MTOC). Cargo-motor complex will experience ballistic transport when bound to microtubules, or dif...