Melanie Cocco
Melanie Cocco
Bedaquiline inhibits the ATP synthase leak channel and prevents glutamate-induced neuronal death [0.03%]
bedaquiline通过抑制ATP合酶泄漏通道预防谷氨酸诱导的神经元死亡
Amrendra Kumar,Olesia Lunko,Erin Smith et al.
Amrendra Kumar et al.
FOF1-ATP synthase is one of the most abundant proteins of the mitochondrial inner membrane and the primary enzyme responsible for ATP production in eukaryotic cells. Nevertheless, it was recently reported to play a prominent role in cell de...
Distinct Disassembly Modes Shape Cytoskeletal Assembly and Fluctuations [0.03%]
独特的解聚模式塑造细胞骨架组装和振荡行为
Md Sorique Aziz Momin,Michaela Cohen,Lishibanya Mohapatra
Md Sorique Aziz Momin
How distinct cytoskeletal structures assemble and maintain their characteristic sizes on different timescales while drawing from a shared pool of subunits remains an open question in cell biology. Experiments indicate that mechanisms promot...
Objective clustering protocol for single-molecule data: A lifetime vs. intensity study [0.03%]
单分子数据的目标聚类协议：寿命与强度研究
Michael A C Lovemore,Bertus van Heerden,Joshua L Botha et al.
Michael A C Lovemore et al.
Single-molecule spectroscopy (SMS) is an exceptionally sensitive technique, but its inherently limited photon budget produces noisy data that can readily lead to subjective analyses, fitting errors, and reduced statistical power, obscuring ...
Aylin Balmes,Vincent Gidlund,Tilman E Schäffer
Aylin Balmes
Platelets are small, anucleate cells critical for hemostasis and thrombosis. Within platelet plugs and narrow capillaries, they often encounter spatially confining microenvironments. To examine how confinement influences platelet properties...
Effect of the gut microbiota metabolite phenylacetylglycine on cardiac Ca2+ signaling [0.03%]
肠道微生物代谢产物苯乙酰甘氨酸对心脏钙信号的作用
Elisa Bovo,Aleksey V Zima
Elisa Bovo
Phenylacetylglutamine (PAGln) and phenylacetylglycine (PAGly) are small molecules derived from the metabolism of phenylalanine by gut microbiota. Elevated levels of PAGln and PAGly in serum have been associated with increased risks for card...
A dynamic duo: Copper metalloregulators and continuous-wave electron spin resonance spectroscopy [0.03%]
铜金属调节剂和连续波电子顺磁共振谱的动态组合
Alysia Mandato,Sunil Saxena,Sharon Ruthstein
Alysia Mandato
This review highlights the use of continuous-wave electron spin resonance (ESR) spectroscopy to investigate protein site-specific dynamics and metal coordination in bacterial copper metalloregulators. ESR provides direct insight into how me...
Silvio Bianchi,Giacomo Donini,Maria Cristina Cannarsa et al.
Silvio Bianchi et al.
E. coli swimming motility is powered by the flagellar motor, a rotary nanomachine driven by inward proton flux through its torque-generating stators. How these proton currents arise from proton motive force is often described using a simple...
Martín A Toderi,Dzmitry Vaido,Dolores Bozovic
Martín A Toderi
While the transduction process has been well-studied in hair cells, the possible presence of mechanical perturbations in the hair cell soma has not been explored in non-mammalian species. Hair cell mechanotransduction involves rapid biophys...
Jared J Topham,Ali Al-Khaz&#x;Aly,Salim Ghandorah et al.
Jared J Topham et al.
Vibrational frequency profiling (VFP) using optical tweezers (OT) has emerged as a promising technique to characterize single cell behavior for diagnostic applications. These applications include cancer screening, identifying bacterial resi...