Spatial confinement alters morphology, spreading dynamics, and mechanics of adherent platelets [0.03%]
空间限制改变了黏附血小板的形态、铺展动力学和力学属性
Johanna G Rodríguez,Jan Seifert,Vincent Gidlund et al.
Johanna G Rodríguez et al.
Platelets are small blood cells involved in hemostasis and wound healing. After activation, platelets interact with their surrounding environment and respond to biochemical and mechanical stimuli by mechanosensitive and haptotactic mechanis...
Automated Tracking of Learned Actin Structures (ATLAS) in the Motility Assay [0.03%]
黏附斑运动实验中细胞骨架肌动蛋白结构的自动追踪系统(ATLAS)
Sebastian Duno-Miranda,David M Warshaw,Shane R Nelson
Sebastian Duno-Miranda
The In Vitro Motility Assay (IVMA) is a widely used experimental system to study the chemical and mechanical activity of myosin and other cytoskeletal motor proteins. In the IVMA, myosin molecules are bound to a glass surface and propel flu...
Z Zhang,J N Milstein
Z Zhang
Axial optical tweezers provide a natural geometry for performing biomechanical assays such as rupture force measurements of protein binding. Axial traps, however, are typically weaker than their lateral counterparts requiring high laser pow...
Qiang Li,Vince D Calhoun
Qiang Li
The human brain exhibits intricate spatiotemporal dynamics, which can be described and understood through the framework of complex dynamic systems theory. In this study, we leverage functional magnetic resonance imaging (fMRI) data to inves...
Quantitative Analysis of Mechanical-Cytoskeletal Coupling in Human Corneal Cells across Myopia Severity Levels∗ [0.03%]
不同程度近视的人类角膜细胞机械-细胞骨架耦合的定量分析
Geng Junyuan,Lu Yue,Li Shuangcheng et al.
Geng Junyuan et al.
Myopia is a prevalent refractive eye disorder closely associated with alterations in corneal biomechanical properties. As fundamental units of corneal tissue, corneal cells significantly influence myopia progression through their nanomechan...
Sub-quantal release is not dominant during prolonged depolarization in adrenal chromaffin cells [0.03%]
肾上腺嗜铬细胞长时间去极化期间亚量化释放不占优势
Lisi Wei,Xin Wang,Min Sun et al.
Lisi Wei et al.
Exocytosis, which mediates important functions like synaptic transmission and stress responses, has been postulated to release all transmitter molecules in the vesicle in the "all-or-none" quantal hypothesis. Challenging this hypothesis, am...
Sanket Patil,Giuseppe Vicidomini,Eli Slenders
Sanket Patil
Super-resolution microscopy has enabled imaging at nanometer-scale resolution. However, achieving this level of detail without introducing artifacts that could mislead data interpretation requires maintaining sample stability throughout the...
Mechanical properties of mandibular and maxillary bone collagen fibrils based on nonlocal elasticity theory [0.03%]
基于非局部弹性理论的下颌骨和上颌骨胶原纤维力学性能研究
Elaheh Alibeigi,Alireza Shahidi,Behnaz Ebadian
Elaheh Alibeigi
In this paper, mechanical properties of collagen fibrils in the cortical bone and cortical-trabecular bone interface of the human mandible and maxilla have been investigated. Force-indentation curves on wet collagen fibrils are taken by app...
Tracking Protein Transitions Through Fluorescence Spectral Phasor Analysis with ACDAN [0.03%]
基于ACDAN的荧光光谱相位分析及其追踪蛋白转换的应用研究
Leandro Cruz Rodríguez,Nahuel Naum Foressi,María Soledad Celej
Leandro Cruz Rodríguez
This study investigates the use of spectral phasor analysis, hyperspectral imaging, and ACDAN fluorescence to explore key protein transitions: unfolding, amyloid aggregation, and liquid-liquid phase separation. We show that ACDAN fluorescen...
Surface-bound FXIII Enhances Deposition and Straightness of Fibrin Fibers [0.03%]
表面结合的FXIII增强纤维蛋白纤维的沉积和直度
Myra Awan,Maya Papez,Ankita P Walvekar et al.
Myra Awan et al.
Crosslinked fibrous networks are central to maintaining the structural integrity and functional relevance of many biological and engineered materials. Fibrin networks are the building blocks of blood clots, mediators of tissue injury and re...