IGF2BP3 As a Prognostic Biomarker and Regulator of Metastasis in Merkel Cell Carcinoma [0.03%]
IGF2BP3作为默克尔细胞癌预后生物标志物和转移调控因子
Yajie Yang,Jiwei Gao,Hao Shi et al.
Yajie Yang et al.
Merkel cell carcinoma (MCC) is an aggressive skin cancer with frequent metastasis; however, effective treatment options for advanced disease are often lacking. In this study, we investigated the clinical significance and functional impact o...
Sharan Kumar Balaji,Bhavani Balasundarasekar,Waris Muhammad Khuwaja et al.
Sharan Kumar Balaji et al.
Antimicrobial peptides (AMPs) are important innate immune molecules at microbe-host interfaces. The biophysical properties of AMPs that facilitate direct killing of microbes have been extensively reviewed. In this article, we focus on how A...
Noncutaneous Infections in Patients with Hidradenitis Suppurativa: A Retrospective Cohort Study [0.03%]
汗孔炎性脓肿患者中的非皮肤感染的回顾性队列研究
Bruna G O Wafae,Alexandra P Charrow,Megan H Noe
Bruna G O Wafae
Adults with hidradenitis suppurativa (HS) have comorbidities and are exposed to treatments that may increase their risk of serious infections. Therefore, our study aims to determine the prevalence and risk factors for noncutaneous infection...
The Role of Fibroblasts in Dystrophic Epidermolysis Bullosa Pathogenesis and Current Treatment Approaches [0.03%]
纤维母细胞在营养不良性表皮松解症发病机制中的作用及目前的治疗策略
Alexander Nyström,Celine Pattaroni,Johannes S Kern
Alexander Nyström
Dystrophic epidermolysis bullosa (DEB) is a hereditary skin fragility disease characterized by the loss or dysfunction of collagen VII, predisposing patients to dermal-epidermal separation. This disease is highly associated with the develop...
Nicole Vecin,Nathan C Balukoff,Marita Yaghi et al.
Nicole Vecin et al.
Hidradenitis suppurativa tunnel structures lined with epithelium within the dermis are unique features of advanced disease stages that significantly impair patients' QOL. The presence of hidradenitis suppurativa tunnels is associated with a...
Detection by Single-Cell RNA Sequencing of Virally Mediated Skin Diseases [0.03%]
单细胞RNA测序鉴定病毒诱发的皮肤病
Linda Zhou,Thomas H Leung
Linda Zhou
Viruses are well-documented agents of specific skin diseases. However, their role and precise mechanism of action in other skin diseases remain unknown. We describe a single-cell RNA-sequencing-based strategy to interrogate human skin biops...
Unpacking the Itch Score: A Critical Examination of Routine Itch Measurement in Dermatology Practice [0.03%]
解开瘙痒评分的谜团：对皮肤科实践中常规瘙痒测量的一次批判性考察
Serene Majid,Steven R Feldman
Serene Majid
Lack of Hypoxia Inducible Factor-1α Influences on Macrophages Ability to Deal with Leishmania braziliensis In Vitro and Affects Pathology In Vivo [0.03%]
缺氧诱导因子-1α缺乏对巨噬细胞处理巴西利什曼原虫的能力的影响及对体内病理学的影响
Rodrigo C O Sanches,Leonardo G Vaz,Fabio V Marinho et al.
Rodrigo C O Sanches et al.
Cutaneous leishmaniasis, caused by Leishmania braziliensis, still represents a serious health problem in Brazil, especially in the northeast region. Currently, to our knowledge, no report describes the role of hypoxia inducible factor-1α (...
Exploring Interaction between Genetically Predicted Body Mass Index and Serum 25-Hydroxyvitamin D Levels on the Odds for Psoriasis in UK Biobank and the HUNT Study: A Factorial Mendelian Randomization Study [0.03%]
英国生物样本库和HUNT研究中基因预测的体重指数与血清25-羟维生素D水平对银屑病几率相互作用的探索：因子孟德尔随机化研究
Marita Jenssen,Nikhil Arora,Mari Løset et al.
Marita Jenssen et al.
Mendelian randomization (MR) studies show that higher body mass index (BMI) and lower 25-hydroxyvitamin D (25[OH]D) increase psoriasis risk. The combined effect of these factors has not been explored using factorial MR. Using cross-sectiona...