Spatiotemporal fluorescence imaging of microRNA activity in 3-D models of human epidermis reveals contribution of the Notch pathway in the regulation of miR-30a in aging skin [0.03%]
时空荧光成像揭示了Notch途径在人皮肤模型中对miR-30a衰老调节的贡献
Alejandro Gonzalez Torres,Fabien P Chevalier,Ruth Aquino et al.
Alejandro Gonzalez Torres et al.
MicroRNAs are short noncoding RNAs that play important roles in fine tuning genetic networks as genes post-transcriptional regulators. Monitoring the regulatory activity of microRNAs is technically challenging, especially in primary cells a...
Spatially controlled induction and regression of basal cell carcinoma, visualized by serial imaging in young and old mice [0.03%]
通过序列影像观察年轻小鼠和年老小鼠基底细胞癌的空域控制感应与消退
Elisabeth A Pedersen,Marina Grachtchouk,Paul W Harms et al.
Elisabeth A Pedersen et al.
Basal cell carcinoma (BCC) is the most common skin malignancy, and the risk of developing BCC increases with age. BCC results from dysregulated Hedgehog signaling leading to activation of GLI transcription factors. In this study, we examine...
Deep intronic MSH2 variant confirms Muir-Torre subtype of Lynch syndrome [0.03%]
深度内含子MSH2变异体证实了Lynch综合征的Muir-Torre亚型
Fiona Chan-Pak-Choon,Andrew Y Shuen,Evan Weber et al.
Fiona Chan-Pak-Choon et al.
Whole-genome sequencing can uncover clinically significant noncoding variants missed by standard germline testing, as demonstrated in this report in a patient with Muir-Torre syndrome, a subtype of Lynch syndrome. In this case, despite a co...
JID Innovations: Supporting innovative skin science in 2025 and beyond with new perspectives [0.03%]
JID创新论坛：以新视角支持2025年及以后的皮肤科学创新
Cristina de Guzman Strong
Cristina de Guzman Strong
Chromatin Accessibility Profiling of Keratinocytes from Clinically Healed Psoriatic Skin Reveals Epigenetic Alterations [0.03%]
银屑病临床治愈皮肤角质形成细胞染色质可及性测序揭示表观遗传改变
Sayaka Shibata,Kentaro Awaji,Asumi Koyama et al.
Sayaka Shibata et al.
Psoriasis is a chronic inflammatory skin disease with recurrence that often reappears at previously affected sites, suggesting an epigenetic imprint in healed skin. However, the chromatin landscape of clinically healed psoriatic keratinocyt...
Russell P Hall rd,J Lamar Callaway
Russell P Hall rd
Topical Salbutamol Cutaneous Gel Is Safe in a Double-Blind, Placebo-Controlled, Randomized Trial of Scarring from Sutured Wound Margins on the Arms of Healthy Human Volunteers [0.03%]
一项双盲安慰剂对照随机试验：健康志愿者前臂缝合伤口边缘愈合时使用色甘酸 topical 舒利迭止喘气雾剂凝胶的安全性
Graham A Johnston,Gareth Squire,Shaun Barber et al.
Graham A Johnston et al.
Salbutamol is a well-established β2-adrenergic receptor agonist used clinically for the reversal of bronchospasm. A functional β2-adrenergic receptor agonist network exists in the skin, which can alter skin cell migration and proliferatio...
Abundances but not concentrations of circulating unsaturated fatty acids are associated with incident psoriatic diseases: Evidence from cohort and Mendelian randomization studies [0.03%]
循环亚饱和脂肪酸的丰度（而不是浓度）与银屑病的发生有关：队列研究和孟德尔随机化研究提供的证据
Minxue Shen,Zhiwei Wang,Danrong Jing et al.
Minxue Shen et al.
Whether the levels of circulating fatty acids (FAs) are associated with psoriasis and psoriatic arthritis remains unknown. To examine the measured and predicted levels of circulating FAs in association with incident psoriatic disease, 2-sam...
Assessing public interest in artificial intelligence in dermatology: A Google Trends analysis [0.03%]
基于Google Trends的人工智能在皮肤病学中的公共利益评估
Matthew J Yan,Yuan Chun Jiang,Shannon Wongvibulsin et al.
Matthew J Yan et al.
Artificial intelligence (AI) is rapidly transforming dermatology, particularly through diagnostic imaging and enhancing patient management. Despite expanding clinical applications, public engagement with AI in dermatology remains underexplo...
Atopic Dermatitis-like mouse model using early inoculation of patient-derived S. aureus together with MC903 [0.03%]
利用人分离的金黄色葡萄球菌早期感染联合MC903试剂建立的小鼠AD模型
Aaroh Joshi,Altan Cornu,Josefa Luxner et al.
Aaroh Joshi et al.
Staphylococcus aureus (S. aureus) worsens atopic dermatitis (AD), but how individual strains differ in pathogenicity remains unclear. Mouse models that mimic AD and allow direct manipulation of S. aureus in early stages of disease are limit...