The Translational Dermatology Initiative: Aiming at a New Disease Classification of Inflammatory Skin Diseases [0.03%]
炎症性皮肤病的新疾病分类：转化皮肤科研究计划
Pontus Jonsson,Anna Caroline Pilz,Heydar Maboudi et al.
Pontus Jonsson et al.
Although precision medicine is at least partially realized in dermato-oncology, the field of dermatoimmunology comprising inflammatory skin diseases is only at the step from traditional toward stratified medicine. This lack of innovation le...
Using Durometers to Quantify Stiffness as an Outcome Measure for Cutaneous Neurofibroma in Neurofibromatosis Type 1 [0.03%]
杜氏硬度计量化神经纤维瘤皮肤僵硬程度作为I型神经纤维瘤的结局指标
Bahir Chamseddin,Renee M McKay,Ruyun Jin et al.
Bahir Chamseddin et al.
Patients with neurofibromatosis type 1 develop multiple cutaneous neurofibromas (cNFs) for which no effective drug therapy exists; mainstay treatment remains physical removal. However, clinical trials testing new drugs are ongoing, and quan...
Nicole E Burma,Michele L Ramien
Nicole E Burma
Alopecia areata (AA) is a common, immune-mediated nonscarring alopecia. Breakdown of immune privilege combined with local immune cell infiltration is central to the development of AA; yet, the instigating factors causing immune dysregulatio...
Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment [0.03%]
一种用于体外脂质损伤模型的人类皮肤等效物的开发，具有可诱导的鞘氨醇脱落现象
Durotimi O Dina,Miriam Maiellaro,Emanuela Camera et al.
Durotimi O Dina et al.
The lipid composition of the epidermis plays a critical role in the skin's barrier function, and defects in lipid synthesis or assembly can cause a spectrum of skin diseases, ranging from dry skin to severe ichthyoses. The aim of this study...
Weak Sensitizers May Be Associated with CD80 Polymorphisms: Implications for Systemic Contact Dermatitis [0.03%]
弱敏化物与CD80多态性的关系：系统性接触性皮炎的病因意义
Susan Nedorost,Ge Zhang,Desta Fekedulegn et al.
Susan Nedorost et al.
Chronic irritant dermatitis predisposes to Th2 skewed allergic contact dermatitis. Chronic hand dermatitis due to wet work or childhood- onset irritant flexural dermatitis (AD) is associated with sensitization to weak or non-sensitizing ant...
Tape Strip Profiling of Checkpoint Inhibitor-Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study [0.03%]
有关联性免疫检验点相关皮炎的粘贴剥离检测显示全面T细胞活化：一项初步研究
Camille M Powers,Madeline Kim,Annie Chang et al.
Camille M Powers et al.
Immune checkpoint inhibitors (ICIs) have become mainstay therapy in the treatment of certain cancers. However, they are frequently associated with adverse effects in nontumor tissues. Cutaneous immune-related adverse events are the most pre...
Hiroki Okamoto,Shuo Li,Yuumi Nakamura
Hiroki Okamoto
The skin microbiome plays a crucial role in the pathogenesis of atopic dermatitis (AD), a chronic inflammatory skin disorder strongly associated with microbial dysbiosis, particularly Staphylococcus aureus colonization. However, the mechani...
The Volume-Regulated Anion Channel LRRC8 is Involved in the Initiation of Epidermal Differentiation and is Deregulated in Psoriasis [0.03%]
容积调控阴离子通道LRRC8参与表皮分化启动并在银屑病中表达异常
Magdalena Jahn,Victoria Lang,Oliver Rauh et al.
Magdalena Jahn et al.
Recent studies have shown that LRRC8A, the essential subunit of the volume-regulated anion channel LRRC8, which is responsible for mediating cell volume regulation during hypotonic stress, is predominantly localized in the basal layer of th...
Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics [0.03%]
通过单细胞 transcriptome 揭示皮肤移植物抗宿主病中的角质形成细胞和免疫微环境的特征
Amy J Petty,Adela Rambi Cardones,Yingai Jane Jin et al.
Amy J Petty et al.
Cutaneous manifestations are the most common presenting sign of chronic graft-versus-host disease (GVHD), and the extent of cutaneous involvement is also highly correlated with prognosis. Very little is understood about the underlying patho...
Wnt Signaling in Male Genital Lichen Sclerosus, Differentiated Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma [0.03%]
Wnt信号在男性生殖器扁平苔藓、分化型阴茎原位癌和阴茎鳞状细胞癌中的作用
Georgios Kravvas,Boyu Xie,Michael Millar et al.
Georgios Kravvas et al.
Introduction: Male genital lichen sclerosus (MGLSc) is a chronic inflammatory disease causing scarring and significant morbidity, and predisposing individuals to differentiated penile intraepithelial neoplasia (dPeIN) and...