Assessment of Primary Malignancy Risk after Initiation of Biologic Therapy in Patients with Psoriasis [0.03%]
银屑病患者开始生物制剂治疗后的原发恶性肿瘤风险评估
Chunghwan Ro,Ana Ormaza Vera,Waleed Adawi et al.
Chunghwan Ro et al.
Limited evidence exists regarding the long-term oncologic safety of biologic therapies, particularly IL-17 inhibitors and IL-23 inhibitors, in the management of psoriasis. This propensity score-matched retrospective cohort study assessed th...
Identification of Keratin 5-Expressing Fibroblasts for Regenerating Keratinocytes in the Necrotic Skin Graft [0.03%]
鉴定表达角蛋白5的纤维细胞以在坏死皮肤移植中再生表皮细胞
Yoshikazu Hirose,Asaka Miura,Yuki Kobayashi et al.
Yoshikazu Hirose et al.
Skin transplantation is commonly used to compensate for normal cutaneous tissues in full-thickness wounds or surgically excised skin. Despite complete termination of initial blood flow, transplanted skin usually maintains its dermal and epi...
Vincent van Drongelen,Joanna Rew,Allison C Billi
Vincent van Drongelen
Autoimmune diseases result from the immune system's inability to discriminate between self and foreign antigens, leading to development of self-reactive immune cells and autoantibodies that can cause organ damage and failure. It has long be...
Accounting for Biological Sex and Gender Identity in the Pathogenesis, Artistic Depictions, and Quality of Life in Neurofibromatosis Type 1 [0.03%]
从神经纤维瘤病Ⅰ型的发病机制、艺术描绘和生活质量方面探讨生物性别和性别认同的影响
Nidhi Kuchimanchi,Renee M McKay,Lu Q Le
Nidhi Kuchimanchi
Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous syndrome caused by pathogenic alterations in the tumor suppressor protein neurofibromin. NF1 is characterized clinically by café-au-lait macules, skinfold freckling, ir...
Investigating Transcriptional Age Acceleration in Inflammatory Skin Diseases [0.03%]
探究炎症性皮肤病中转录衰老的加速现象
Richie Jeremian,Melissa Galati,Rayyan Fotovati et al.
Richie Jeremian et al.
Epigenetic age acceleration has previously been observed in inflammatory skin disease; however, less is known regarding recently described age-related gene expression patterns ("transcriptional clocks"). We investigated the role of transcri...
Katie Ridge,Barry Moran,Mark A Little et al.
Katie Ridge et al.
Chronic spontaneous urticaria and atopic dermatitis (AD) are chronic skin disorders characterized by itch. Although mast cells play an integral role in the pathogenesis of chronic spontaneous urticaria, their role in AD is unclear, having a...
MC1R and IRF4 Gene Variants Are Associated with p16INK4a-Positive Epidermal Cells [0.03%]
MC1R和IRF4基因变异与p16INK4阳性表皮细胞相关
Jasmine Vilaplana Murdoch,Raymond Noordam,P Eline Slagboom et al.
Jasmine Vilaplana Murdoch et al.
Basal cell carcinoma (BCC) cases in sun-protected skin are estimated to be between 20 and 33% of total cases, highlighting a non-UVR influence on BCC incidence. In this study, we tested the hypothesis that BCC risk is associated with cell s...
Effect of Topical Corticosteroid Treatment on microRNA Expression in Infants with Atopic Dermatitis [0.03%]
外用皮质类固醇治疗对特应性皮炎患儿miRNA表达的影响研究
Janna Nousbeck,Maeve A McAleer,Elaine M Kenny et al.
Janna Nousbeck et al.
MicroRNAs (miRNAs) have been implicated in a variety of disorders. Although studies have examined miRNA in pediatric atopic dermatitis (AD), the impact of topical corticosteroid (TCS) therapy on miRNA expression in pediatric AD has not been...
Evaluating the Associations between Dietary Vitamin Intake and Atopic Dermatitis: A Regional Cross-Sequential Study among Singapore and Malaysia Young Chinese Adults [0.03%]
饮食维生素摄入与特应性皮炎的关联评价——新加坡和马来西亚青年华人区域横断队列研究
Jun Jie Lim,Kavita Reginald,Yee-How Say et al.
Jun Jie Lim et al.
This study demonstrates that naturally derived vitamins, estimated from whole foods in the diets of young Chinese adults from Singapore and Malaysia, are associated with atopic dermatitis (AD). Higher intake of vitamins E, K1, C, B2, and D ...
Toward the Next Generation of In Silico Modeling of Dynamic Host-Microbiota Interactions in the Skin [0.03%]
面向下一代皮肤动态宿主-微生物群相互作用的计算机模型的发展
Jamie Lee,Hiu Lam Athena Wu,Ahmad A Mannan et al.
Jamie Lee et al.
Understanding how the skin microbiota contributes to skin health and disease requires knowledge of the dynamic interactions between the skin and its resident microbes. In silico modeling complements in vivo and in vitro experiments by enabl...