Topical Salbutamol Cutaneous Gel Is Safe in a Double-Blind, Placebo-Controlled, Randomized Trial of Scarring from Sutured Wound Margins on the Arms of Healthy Human Volunteers [0.03%]
一项双盲安慰剂对照随机试验：健康志愿者前臂缝合伤口边缘愈合时使用色甘酸 topical 舒利迭止喘气雾剂凝胶的安全性
Graham A Johnston,Gareth Squire,Shaun Barber et al.
Graham A Johnston et al.
Salbutamol is a well-established β2-adrenergic receptor agonist used clinically for the reversal of bronchospasm. A functional β2-adrenergic receptor agonist network exists in the skin, which can alter skin cell migration and proliferatio...
Abundances but not concentrations of circulating unsaturated fatty acids are associated with incident psoriatic diseases: Evidence from cohort and Mendelian randomization studies [0.03%]
循环亚饱和脂肪酸的丰度（而不是浓度）与银屑病的发生有关：队列研究和孟德尔随机化研究提供的证据
Minxue Shen,Zhiwei Wang,Danrong Jing et al.
Minxue Shen et al.
Whether the levels of circulating fatty acids (FAs) are associated with psoriasis and psoriatic arthritis remains unknown. To examine the measured and predicted levels of circulating FAs in association with incident psoriatic disease, 2-sam...
Assessing public interest in artificial intelligence in dermatology: A Google Trends analysis [0.03%]
基于Google Trends的人工智能在皮肤病学中的公共利益评估
Matthew J Yan,Yuan Chun Jiang,Shannon Wongvibulsin et al.
Matthew J Yan et al.
Artificial intelligence (AI) is rapidly transforming dermatology, particularly through diagnostic imaging and enhancing patient management. Despite expanding clinical applications, public engagement with AI in dermatology remains underexplo...
Atopic Dermatitis-like mouse model using early inoculation of patient-derived S. aureus together with MC903 [0.03%]
利用人分离的金黄色葡萄球菌早期感染联合MC903试剂建立的小鼠AD模型
Aaroh Joshi,Altan Cornu,Josefa Luxner et al.
Aaroh Joshi et al.
Staphylococcus aureus (S. aureus) worsens atopic dermatitis (AD), but how individual strains differ in pathogenicity remains unclear. Mouse models that mimic AD and allow direct manipulation of S. aureus in early stages of disease are limit...
Assessing T-Cell Profile Shifts through IL-23 Inhibition by Guselkumab on Psoriasis [0.03%]
古塞库单抗抑制Psoriasis患者IL-23致T细胞谱系转变的评估研究
Yoshifumi Kanayama,Oki Watanabe,Mai Sakurai et al.
Yoshifumi Kanayama et al.
Anti-IL-23 antibody therapies improve the underlying immunopathology of psoriasis. Immune profile dynamics after anti-IL-23 treatment and their association with the treatment response are unclear. Focusing on guselkumab, an anti-IL-23p19 an...
Pemphigus Is not Associated with an Increased Risk of Psychiatric Disorders during the Course of the Disease [0.03%]
自身免疫性大疱病与精神疾病风险无关
Shirin Emtenani,Salam Alfarsi,Philip Curman et al.
Shirin Emtenani et al.
Pemphigus is a rare, severe autoimmune blistering disease caused by autoantibodies targeting desmosomal proteins, leading to intraepithelial blistering and painful erosions of the skin and mucous membranes. Although 10-15% of dermatology pa...
Mucosal-Associated Invariant T (MAIT) Cells in Skin Immunity: Metabolic Regulation, Tissue Adaptation, and Roles in Skin Inflammation and Disease [0.03%]
黏膜相关不变T(MAIT)细胞在皮肤免疫中的作用：代谢调控、组织适应及在皮肤病和炎症中的作用
Namya Nanda,Chloe Kim,Ishita Jain et al.
Namya Nanda et al.
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that recognize microbial-derived vitamin B metabolites presented by the nonpolymorphic MR1 (major histocompatibility complex class I-related protei...
Characterization of Malignant Adnexal Tumors of the Head and Neck by Targeted Analysis of Cancer Genes and Human Papillomavirus 42 [0.03%]
靶向分析癌症基因和人乳头瘤病毒表征头部和颈部恶性附件肿瘤42
Eleanor Dowell,Ruchika Mahapatra,Justin Bishop et al.
Eleanor Dowell et al.
Malignant adnexal tumors of the head and neck, including syringoid eccrine carcinoma and microcystic adnexal carcinoma, are rare tumors that are thought to arise in adnexal epithelium. The etiopathogenesis of these tumors is poorly understo...
Nanostring Transcriptomic Analysis Highlights IL-6 Family and TGF-β Pathways in the Pathogenesis of Prurigo Nodularis [0.03%]
NanoString转录谱分析揭示了白细胞介素-6族和转化生长因子-β信号通路在结节性痒疹发病机制中的作用
Yagiz Matthew Akiska,Shrey Bhatt,Kavita Vats et al.
Yagiz Matthew Akiska et al.
Prurigo nodularis (PN) is a chronic, neuroimmune-driven skin disease characterized by intensely pruritic nodules and marked impairment in QOL. Although PN shares inflammatory features with atopic dermatitis and psoriasis, its underlying pat...
Clinician and Patient Perspectives in Oral Lichen Planus: Correlation and Drivers of Disease Severity and QOL [0.03%]
口腔扁平苔藓的医患观点：疾病严重程度和生活质量的相关性及影响因素
Emma L Myers,Sarah G McAlpine,Donna A Culton
Emma L Myers
Oral lichen planus is a chronic, immune-mediated inflammatory condition that significantly impacts QOL. Clinician-reported measures, such as the Oral Disease Severity Score (ODSS), systematically evaluate clinical severity but may not adequ...