Dermoscopy-guided high-frequency ultrasound: Principles and applications in dermatology [0.03%]
Dermosonography：原理及其在皮肤科的应用
Mehdi Boostani,Ximena Wortsman,Giovanni Pellacani et al.
Mehdi Boostani et al.
Conventional skin imaging modalities are often bulky, expensive, and impractical for routine dermatology practice. There is a need for a portable, multimodal imaging tool that integrates high-resolution surface and subsurface visualization ...
Population- and haplotype-dependent variation around TYR rs1126809: An in silico study for melanoma risk research [0.03%]
基于人群和单体型的TYR基因rs1126809位点多态性差异：一种黑色素瘤风险研究的计算方法学研究
Árpád Ármin Balogh,Márta Széll,Nikoletta Nagy
Árpád Ármin Balogh
The common missense variant rs1126809 in the TYR gene, encoding a key enzyme in melanin synthesis, is linked to both albinism and melanoma susceptibility. Although its role in hypopigmentation as part of a risk haplotype is established, its...
A standardized approach to test missense PNPLA1 rare genetic variants of uncertain significance in epidermal differentiation disorders [0.03%]
表皮分化障碍未知意义的PNPLA1稀有错义基因变异标准化检测方法
Nuria Pell,Pauline Bernard,Séverine Courrech et al.
Nuria Pell et al.
Congenital ichthyoses, now renamed epidermal differentiation disorders (EDDs) (syndromic EDD or nonsyndromic EDD), are rare, disabling conditions caused by sequence variations in epidermal barrier genes. However, 5-10% of variants, called "...
Human keratinocytes exhibit limited potential for SARS-CoV-2 infection despite ACE2 and mature cathepsin L expression [0.03%]
人角质形成细胞表达ACE2和成熟的猫科天冬氨酸蛋白酶L，但其对SARS-CoV-2感染的敏感性较低
Leslie Hertereau,Manon Barthe,Noura Lamghari et al.
Leslie Hertereau et al.
The distribution of receptors and cellular factors across tissues determines differential susceptibility of cells to viral infection. For severe acute respiratory syndrome coronavirus 2, viral spike and nucleocapsid proteins have been detec...
Spatiotemporal fluorescence imaging of microRNA activity in 3-D models of human epidermis reveals contribution of the Notch pathway in the regulation of miR-30a in aging skin [0.03%]
时空荧光成像揭示了Notch途径在人皮肤模型中对miR-30a衰老调节的贡献
Alejandro Gonzalez Torres,Fabien P Chevalier,Ruth Aquino et al.
Alejandro Gonzalez Torres et al.
MicroRNAs are short noncoding RNAs that play important roles in fine tuning genetic networks as genes post-transcriptional regulators. Monitoring the regulatory activity of microRNAs is technically challenging, especially in primary cells a...
Spatially controlled induction and regression of basal cell carcinoma, visualized by serial imaging in young and old mice [0.03%]
通过序列影像观察年轻小鼠和年老小鼠基底细胞癌的空域控制感应与消退
Elisabeth A Pedersen,Marina Grachtchouk,Paul W Harms et al.
Elisabeth A Pedersen et al.
Basal cell carcinoma (BCC) is the most common skin malignancy, and the risk of developing BCC increases with age. BCC results from dysregulated Hedgehog signaling leading to activation of GLI transcription factors. In this study, we examine...
Deep intronic MSH2 variant confirms Muir-Torre subtype of Lynch syndrome [0.03%]
深度内含子MSH2变异体证实了Lynch综合征的Muir-Torre亚型
Fiona Chan-Pak-Choon,Andrew Y Shuen,Evan Weber et al.
Fiona Chan-Pak-Choon et al.
Whole-genome sequencing can uncover clinically significant noncoding variants missed by standard germline testing, as demonstrated in this report in a patient with Muir-Torre syndrome, a subtype of Lynch syndrome. In this case, despite a co...
JID Innovations: Supporting innovative skin science in 2025 and beyond with new perspectives [0.03%]
JID创新论坛：以新视角支持2025年及以后的皮肤科学创新
Cristina de Guzman Strong
Cristina de Guzman Strong
Chromatin Accessibility Profiling of Keratinocytes from Clinically Healed Psoriatic Skin Reveals Epigenetic Alterations [0.03%]
银屑病临床治愈皮肤角质形成细胞染色质可及性测序揭示表观遗传改变
Sayaka Shibata,Kentaro Awaji,Asumi Koyama et al.
Sayaka Shibata et al.
Psoriasis is a chronic inflammatory skin disease with recurrence that often reappears at previously affected sites, suggesting an epigenetic imprint in healed skin. However, the chromatin landscape of clinically healed psoriatic keratinocyt...
Russell P Hall rd,J Lamar Callaway
Russell P Hall rd