Pyrotinib in HER2 heterogeneously mutated or amplified advanced non-small cell lung cancer patients: a retrospective real-world study (PEARL) [0.03%]
吡咯替尼治疗HER2异质性突变或扩增的晚期非小细胞肺癌患者：真实世界回顾性研究(PEARL)研究
Guangjian Yang,Xuezhi Hao,Jiaqi Hu et al.
Guangjian Yang et al.
Human epidermal growth factor receptor 2 (HER2) amplification or activating mutations are found in 1.6%-4% of non-small cell lung cancer (NSCLC). Pyrotinib has been reported to have better potency in NSCLC patients with HER2 exon 20 inserti...
Guidelines for clinical practice of ALK fusion detection in non-small-cell lung cancer: a proposal from the Chinese RATICAL study group [0.03%]
非小细胞肺癌ALK融合基因检测中国专家共识提案（ RATICAL研究小组）
Wenbin Li,Jing Zhang,Zhijie Wang et al.
Wenbin Li et al.
The presence of anaplastic lymphoma kinase (ALK) rearrangement defines a molecular subtype of non-small cell lung cancer (NSCLC). ALK inhibitors (ALKIs) confer significant clinical benefits in patients with ALK-positive advanced NSCLC; ther...
Evolution and genotypic characteristics of small cell lung cancer transformation in non-small cell lung carcinomas [0.03%]
非小细胞肺癌向小细胞肺癌转化的演变及基因型特征
Jia Zhong,Xiaoting Li,Zhijie Wang et al.
Jia Zhong et al.
Background: Small cell lung cancer (SCLC) transformation had previously been reported mainly in epidermal growth factor receptor (EGFR) mutant adenocarcinoma. However, the underlying genomic profile remains unclear. Our s...
Results of the cancer screening feasibility study in China: a multicentered randomized controlled trial of lung and colorectal cancer screening [0.03%]
中国癌症筛查可行性研究结果——肺癌和结直肠癌筛查多中心随机对照试验
Jiang Li,Ping Hu,Jufang Shi et al.
Jiang Li et al.
Background: To provide an understanding of important aspects of the participant recruitment and data collection, become aware of any potential problems, and obtain necessary information in order to design a large-scale ra...
Expert consensus on diagnosis, treatment and fertility management of young breast cancer patients [0.03%]
青年乳腺癌患者诊断、治疗及生育力保存专家共识
Committee Of Diagnosis Treatment And Fertility Management Of Chinese Young Breast Cancer Patients
Committee Of Diagnosis Treatment And Fertility Management Of Chinese Young Breast Cancer Patients
Breast cancer in young females is a relatively common disease in China. Young breast cancer has aggressive clinical and pathological features. During the treatment of young females with breast cancer, issues involving the choice of surgical...
Inaugural Editorial [0.03%]
创刊号评论文章
Jie He
Jie He
Siwei Zhang,Kexin Sun,Rongshou Zheng et al.
Siwei Zhang et al.
Background: National Cancer Center (NCC) updated nationwide cancer statistics using population-based cancer registry data in 2015. Methods: ...
Chromatin assembly factor 1 suppresses epigenetic reprogramming toward adaptive drug resistance [0.03%]
染色质装配因子1通过表观重编程抑制药物适应性耐药效应
Zhiquan Wang,Rentian Wu,Qian Nie et al.
Zhiquan Wang et al.
The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased ...
Interplay between oral health and lifestyle factors for cancer risk in rural and urban China: a population-based cohort study [0.03%]
中国农村和城市人口口腔健康与癌症风险的生活方式因素的相互作用：基于人口的队列研究
Chao Sheng,Xi Zhang,Ben Liu et al.
Chao Sheng et al.
Background: Although poor oral health and several lifestyle factors have been found to be associated with cancer risk, their joint relationship has rarely been studied. ...
Predictive function of tumor burden-incorporated machine-learning algorithms for overall survival and their value in guiding management decisions in patients with locally advanced nasopharyngeal carcinoma [0.03%]
基于肿瘤负荷的机器学习算法预测模型在局部区域晚期鼻咽癌患者预后中的价值及指导治疗中的作用研究
Yang Liu,Shiran Sun,Ye Zhang et al.
Yang Liu et al.
Objective: Accurate prognostic predictions and personalized decision-making on induction chemotherapy (IC) for individuals with locally advanced nasopharyngeal carcinoma (LA-NPC) remain challenging. This research examined...