Efficacy and safety comparisons of PD-1 versus PD-L1 inhibitors in patients with solid cancer: a systematic review and meta-analysis [0.03%]
程序性死亡配体1抑制剂与程序性死亡受体1抑制剂治疗实体瘤的疗效及安全性比较：系统评价和荟萃分析
Jun Yu,Qiaoxia Zhou,Guoqiang Wang et al.
Jun Yu et al.
Background: A comprehensive evaluation between PD-1 and PD-L1 inhibitors is critical for appropriate treatment choice. To evaluate the efficacy and safety of PD-1 and PD-L1 inhibitors, this meta-analysis was conducted thr...
MCLAM: a cost-effective deep learning model for predicting recurrence risk in HR+/HER2- breast cancer-a multi-center study in a Chinese cohort [0.03%]
MCLAM：一种成本效益高的深度学习模型 用于预测中国HR+/HER2-乳腺癌队列多中心研究的复发风险
Liuliu Quan,Shuyue Chen,Zixuan Yang et al.
Liuliu Quan et al.
Objective: EndoPredict is a gold-standard for HR+/HER2- breast cancer risk stratification but limited by high cost. We propose Multi-modal Clustering-constrained Attention Multiple Instance Learning (MCLAM), a novel deep ...
Extracellular vesicles in prostate cancer: current understanding and future perspectives [0.03%]
外泌体和前列腺癌：目前的认识及未来展望
Balaji Perumalsamy,Parthasarathy Seshacharyulu,Raghupathy Vengoji et al.
Balaji Perumalsamy et al.
Exosomes are nanoscale, lipid bilayer extracellular vesicles (EVs) actively secreted by cells under both physiological and pathological conditions. As key mediators of intercellular communication, exosomes carry a diverse array of molecular...
Female underrepresentation and adverse events reporting biases in lung cancer clinical trials: a systematic review and meta-analysis [0.03%]
一项系统评价和Meta分析：肺癌临床试验中的女性代表性不足及不良事件报告偏差
Yena Gan,Rui Tian,Sheng Han et al.
Yena Gan et al.
Objective: Despite regulatory initiatives to improve female representation in clinical trials, sex-based disparities persist, particularly in oncology. This is of concern given the rising burden of lung cancer in women. W...
Migrasomes program tissue microenvironment: from physiology to oncology, future perspectives in clinical advances [0.03%]
迁移体调控组织微环境：从生理到肿瘤学，临床进展的未来展望
Shaosen Zhang,Jiaoting Chen,Yancheng Lai et al.
Shaosen Zhang et al.
Cancer remains a critical global health challenge, necessitating an in-depth investigation into spatiotemporal dimensions. Migrasomes, a class of migration-dependent organelles that sequester spatiotemporal and biochemical cues, offer a pre...
Construction and external validation of radiomics models to detect primary prostate cancer with machine learning: a multicenter study based on 68Ga-PSMA PET/CT [0.03%]
基于68Ga-PSMA PET/CT的机器学习放射组学模型检测前列腺癌的构建与外部验证：多中心研究
Jiaxian Chen,Xin Jiang,Guangjie Yang et al.
Jiaxian Chen et al.
Objective: Recent studies have shown that 68Ga-prostate-specific membrane antigen (68Ga-PSMA) positron emission tomography/computed tomography (PET/CT) can open a non-invasive diagnostic pathway in prostate cancer (PCa). ...
Study of the blood-brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases [0.03%]
研究KRAS G12C突变非小细胞肺癌脑转移患者入血脑屏障的KRAS G12C抑制剂JMKX1899
Danming He,Yixiang Zhu,Jia Zhong et al.
Danming He et al.
Background: Patients with non-small cell lung cancer (NSCLC) harboring KRAS G12C mutations frequently develop brain metastases (BM). While KRAS G12C was once considered an undruggable target, the emergence of selective in...
Global patterns of upper gastrointestinal cancer incidence by subtype and subsite in 2022: a population-based study [0.03%]
2022年全球主要胃肠道癌症亚型和解剖部位的发病模式：基于人群的研究
Yuanjie Zheng,Nuopei Tan,Yi Teng et al.
Yuanjie Zheng et al.
Objective: To provide an updated global assessment of esophageal and gastric cancers incidence by histological subtype and anatomical subsite. Methods: ...
Jingwei Zhang,Md Imtiaz Khalil,Ranjan Mishra et al.
Jingwei Zhang et al.
Metastatic relapse is frequently driven by dormant disseminated tumor cells (DTCs) that previously evaded initial therapy, disseminated to distant tissues, entered into a non-proliferative state termed dormancy, and later reawakened to rein...
Stratification system with tumor-associated macrophages for predicting prognostic and therapeutic implications in clear cell renal cell carcinoma [0.03%]
基于肿瘤相关巨噬细胞的分层系统用于预测透明细胞肾细胞癌预后及治疗意义
Jiahe Lu,Shiqi Ye,Zhongyuan Wang et al.
Jiahe Lu et al.