Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations [0.03%]
果蝇的eQTL饱和图谱：杂交群体中转录变异的顺式和反式调控的全基因组模式
Luisa F Pallares,Diogo Melo,Scott Wolf et al.
Luisa F Pallares et al.
Most genetic polymorphisms associated with complex traits are found in non-coding regions of the genome. Characterizing their effect presents a formidable challenge, and expression quantitative trait locus (eQTLs) mapping has been a key app...
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development [0.03%]
类人猿特有的逆转录转座子为早期大脑发育提供调控新颖性
Larisa Okorokova,Gael Cristofari
Larisa Okorokova
Transposable elements can drive genetic innovation. In this issue of Cell Genomics, Adami et al.1 investigate the impact of hominoid-specific L1 retrotransposons on early embryonic and brain development. Using induced pluripotent stem cells...
Single-cell and spatial detection of senescent cells using DeepScence [0.03%]
利用DeepScence进行单细胞和空间衰老细胞检测
Yilong Qu,Beijie Ji,Runze Dong et al.
Yilong Qu et al.
Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics d...
Chromosome-specific epigenetic control and transmission of ribosomal DNA arrays in Hominidae genomes [0.03%]
黑猩猩和人类基因组中端粒化核仁DNA阵列的表观遗传控制与跨代稳定传递机制研究
Tamara A Potapova,Paxton Kostos,Sean McKinney et al.
Tamara A Potapova et al.
Ribosomal RNA (rRNA) genes are organized in tandem arrays known as ribosomal DNA (rDNA) on multiple chromosomes in Hominidae genomes. We measured copy number and transcriptional activity status of rRNA gene arrays across multiple individual...
Multi-omic underpinnings of heterogeneous aging across multiple organ systems [0.03%]
跨多个器官系统的异质性衰老的多组学基础
Jie Xiong,Xiaoting Zhu,Yutong Guo et al.
Jie Xiong et al.
Aging is the main determinant of chronic diseases and mortality, yet organ-specific aging trajectories vary, and the molecular basis underlying this heterogeneity remains unclear. To elucidate this, we integrated genomic, epigenomic, transc...
Biaobang Chen,Weijie Wang,Juanzi Shi et al.
Biaobang Chen et al.
Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet...
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape [0.03%]
重复序列模仿病原体相关模式跨越巨大的进化景观
Petr Šulc,Andrea Di Gioacchino,Alexander Solovyov et al.
Petr Šulc et al.
An emerging hallmark of many human diseases is transcription of typically silenced repetitive DNA containing pathogen-associated molecular patterns (PAMPs). These PAMPs engage the innate immune system via pattern recognition receptors (PRRs...
Galaxy single-cell & spatial omics community update: Navigating new frontiers in 2025 [0.03%]
银河单细胞与空间组学社区更新：2025年的新前沿探索
Marisa Loach,Amirhossein Naghsh Nilchi,Diana Chiang et al.
Marisa Loach et al.
Single-cell omics, named Method of the Year three times, have revolutionized biological research by enabling the high-resolution exploration of cellular heterogeneity and molecular processes. Initially centered on transcriptomics, this rapi...
Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex [0.03%]
人类大脑皮层中细胞特异性DNA甲基化动态变化贯穿于从妊娠到出生后的全过程
Alice Franklin,Jonathan P Davies,Nicholas E Clifton et al.
Alice Franklin et al.
The human cortex undergoes extensive epigenetic remodeling during development, although the precise temporal and cell-type-specific dynamics of DNA methylation remain incompletely understood. In this study, we profiled genome-wide DNA methy...
Network-based drug repurposing for psychiatric disorders using single-cell genomics [0.03%]
基于单细胞基因组学的网络药物再利用以治疗精神疾病
Chirag Gupta,Noah Cohen Kalafut,Declan Clarke et al.
Chirag Gupta et al.
Neuropsychiatric disorders lack effective treatments due to a limited understanding of the underlying cellular and molecular mechanisms. To address this, we integrated population-scale single-cell genomics data and analyzed 23 cell-type-lev...