Julian Pulecio,Zakieh Tayyebi,Dingyu Liu et al.
Julian Pulecio et al.
It remains unknown whether early embryonic cells harbor a blueprint for future enhancers that regulate the expression of lineage-specific genes in adult tissues. Here, we demonstrate that embryonic stem cells (ESCs) have transcriptionally c...
Junyue Cao
Junyue Cao
In this meet-the-author Q&A, Scientific Editor Sara Rohban and Editor-in-Chief Laura Zahn speak with Junyue Cao about his Cell Genomics paper. He discusses his ambitions to study aging and how his newly developed method, EnrichSci, was used...
A first-principles quantitative framework for how cohesin regulators shape chromatin loop extrusion [0.03%]
首个定量分析共凝素调节物如何塑造染色质环脱逸的理论框架
Zibin Huang,Xinyi Liu,Junjun Ding
Zibin Huang
In this issue of Cell Genomics, Tortora and Fudenberg develop a first-principles framework in which loop extrusion is quantitatively regulated by multiple cohesin-associated factors, giving rise to "bursty extrusion." This model predicts re...
Untangling biological complexity: A deep learning approach to separating multiple signals in single-cell data [0.03%]
解开生物的复杂性：一种用于分离单细胞数据中多重信号的深度学习方法
Christopher Yau
Christopher Yau
Single-cell RNA sequencing (scRNA-seq) provides an instantaneous snapshot of the transcriptional state of a cell, which results from the simultaneous activity of many cellular processes. In this issue of Cell Genomics, Chen et al.1 describe...
Temporal gating of sex-specific apoptosis shapes the sexually dimorphic brain [0.03%]
时间门控的性别特异性凋亡塑形性别二态化大脑
Ben R Hopkins,Artyom Kopp
Ben R Hopkins
Understanding how a largely shared genome specifies distinct male and female behaviors is a central challenge in biology. Two recent papers show how sex-specific apoptosis interacts with neuron birth order in the Drosophila brain to sculpt ...
Long-read genome sequencing improves detection and functional interpretation of structural and repeat variants in autism [0.03%]
长读序列基因组测序改善自闭症的结构变异和重复序列变异的检出及功能分析
Milad Mortazavi,James Guevara,Joshua Diaz et al.
Milad Mortazavi et al.
Long-read whole-genome sequencing (LR-WGS) technologies enhance the discovery of structural variants (SVs) and tandem repeats (TRs). We performed LR-WGS on 267 individuals from 63 autism spectrum disorder (ASD) families and generated an int...
Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies [0.03%]
利用Hi-C技术在常规淋巴癌活检标本中全基因组范围内检测增强子捕获重排事件
Jamin Wu,Shih-Chun A Chu,Jang Cho et al.
Jamin Wu et al.
Standard techniques for detecting genomic rearrangements in formalin-fixed paraffin-embedded (FFPE) biopsies have important limitations. We performed FFPE-compatible Hi-C on 44 clinical biopsies comprising large B cell lymphomas (n = 18), p...
A multiplex, prime editing framework for identifying drug resistance variants at scale [0.03%]
一种用于大规模识别药物抗性变异的多重筛查型prime编辑框架
Florence M C Abadie,Chase C Suiter,Nahum T Smith et al.
Florence M C Abadie et al.
CRISPR-based genome editing has revolutionized functional genomics, enabling thousands of perturbations to be concurrently assayed in single experiments. However, for methods such as saturation genome editing (SGE), which aims to generate a...
Joint modeling of whole-genome sequencing data for human height via approximate message passing [0.03%]
利用近似消息传递法对全基因组测序数据进行建模以研究人类身高变异
Al Depope,Jakub Bajzik,Marco Mondelli et al.
Al Depope et al.
Human height is a model for the genetic analysis of complex traits, and recent studies suggest the presence of thousands of common genetic variant associations and hundreds of low-frequency/rare variants. Here, we develop a new algorithmic ...
Comparative genomics reveals LINE-1 recombination with diverse RNAs [0.03%]
比较基因组学揭示LINE-1与多种RNA的重组现象
Cheuk-Ting Law,Kathleen H Burns
Cheuk-Ting Law
Long interspersed element-1 (LINE-1, L1) retrotransposons are the most abundant protein-coding transposable elements (TEs) in mammalian genomes and have shaped genome content over 170 million years of evolution. LINE-1 is self-propagating a...