Wen-Wei Liang,Simon J Mueller,Sydney K Hart et al.
Wen-Wei Liang et al.
Mammalian genomes host a diverse array of RNAs, including protein-coding and noncoding transcripts. However, the functional roles of most long noncoding RNAs (lncRNAs) remain elusive. Using RNA-targeting CRISPR-Cas13 screens, we probed how ...
Zong-Heng Fu,Yuan Ma,Si Cheng et al.
Zong-Heng Fu et al.
V(D)J recombination, which joins V, D, and J genes across immunoglobulin loci, is essential for antibody diversity. To unlock the inherent constraints of V(D)J recombination, we systematically designed, assembled, and shuffled a synthetic h...
FastGxC: Fast and powerful context-specific eQTL mapping in bulk and single-cell data [0.03%]
FastGxC：在批量和单细胞数据中快速而强大的上下文特异性eQTL映射
Lena Krockenberger,Andrew Lu,Mike Thompson et al.
Lena Krockenberger et al.
Context-specific expression quantitative trait loci (eQTLs) mediate genetic risk for complex diseases, but current methods limit their characterization and interpretation. We introduce FastGxC, a method for efficiently mapping context-speci...
Maria H Chahrour
Maria H Chahrour
Structural and repeat variation relevant to autism has remained largely inaccessible to short-read sequencing. Using long-read genome sequencing, a recent study reveals previously hidden variants at scale, quantifies their contribution to a...
Casey D Gailey,David M Miller rd
Casey D Gailey
Cell surfaces display dense arrays of extracellular proteins that interact with each other and with secreted cues. Nawrocka et al. deployed a biochemical screen to catalog these interactions at genome scale for the model organism C. elegans...
Florence Abadie,Lea Starita
Florence Abadie
In the latest issue of Cell Genomics, Lea Starita, Florence Abadie, and colleagues present "A multiplex, prime editing framework for identifying drug resistance variants at scale." ...
Cheuk-Ting Law,Kathleen H Burns
Cheuk-Ting Law
In this Q&A, the editor-in-chief of Cell Genomics, Dr. Laura Zahn, speaks to Drs. Kathleen Burns and Dicky Law from the Burns lab at the Dana-Farber Institute in Boston about their recent Cell Genomics paper, "Comparative genomics reveals L...
Nikhil Milind,Courtney J Smith,Huisheng Zhu et al.
Nikhil Milind et al.
The genome-wide burdens of deletions, loss-of-function mutations, and duplications correlate with many traits. Curiously, for most of these traits, variants that decrease expression have the same genome-wide average direction of effect as v...
Regulatory network topology and the genetic architecture of gene expression [0.03%]
调控网络拓扑和基因表达的遗传结构
Matthew Aguirre,Jeffrey P Spence,Guy Sella et al.
Matthew Aguirre et al.
Most genetic variance in gene expression is due to trans-acting expression quantitative trait loci (eQTLs) spread across the genome. However, these loci are generally hard to map due to limited discovery power. Here, we simulate how local p...
Interferon-related inflammaging links epigenetic age acceleration to multimorbidity [0.03%]
干扰素相关的炎症老化连接表观遗传衰老加速与多发病态
Zhaoli Liu,Athanasios Ziogas,Yihan Zhang et al.
Zhaoli Liu et al.
Chronic systemic inflammation and DNA methylation changes are two major hallmarks of aging, yet their interaction is poorly known. We investigated the relation between circulating inflammatory proteome and epigenetic age acceleration as ass...