Sihan Li,Zehua Wang,Xiaofei Wang et al.
Sihan Li et al.
Emerging evidence suggests that MYC interacts with RNAs. Here, we performed an integrative characterization of MYC as an RNA-binding protein in six cell lines. We found that MYC binds to a myriad of RNAs with high affinity for guanosine-ric...
Ethics choices during the Human Genome Project reflected their policy world, not ours [0.03%]
人类基因组计划中的伦理选择反映了他们的政策世界，而不是我们的世界
Jonathan E LoTempio Jr,Christopher R Donohue,Jonathan D Moreno et al.
Jonathan E LoTempio Jr et al.
Since human genomic data produced in the 1990s are still a significant part of the reference genome, decades-old decisions pertinent to the creation of these data persist. Here, we discuss how historical documents illustrate the 1990s polic...
Hae Kyung Im
Hae Kyung Im
Hae Kyung Im's research group focuses on quantitative computational and statistical methods to tackle genomic data analysis and provides methods to translate the vast amount of genomic data for health research. In collaboration with Mengjie...
α2 adrenoceptors, cold-induced vasoconstriction, and Raynaud's phenomenon [0.03%]
α2肾上腺素受体、冷诱导血管收缩与雷诺病
Nicholas A Flavahan
Nicholas A Flavahan
Response to Dr. Nicholas A. Flavahan's and Dr. Ali H. Eid's letters regarding our recent publication in Cell Genomics [0.03%]
致Nicholas A. Flavahan博士和Ali H. Eid博士关于我们最近在Cell Genomics上发表的文章的回复
Anniina Tervi,Markus Ramste,Hanna M Ollila
Anniina Tervi
scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework [0.03%]
scPrediXcan整合深度学习方法和单细胞数据构建组织特异性转录组关联研究框架
Yichao Zhou,Temidayo Adeluwa,Lisha Zhu et al.
Yichao Zhou et al.
Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data. H...
Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features [0.03%]
纳米孔直接RNA测序揭示了人类转录组的复杂性及其对信使核糖核酸修饰和调控特征相互作用的影响
Yerin Kim,Luke Saville,Kieran O&#x;Neill et al.
Yerin Kim et al.
The identification and functional characterization of chemical modifications on an mRNA molecule, in particular N6-methyladenosine (m6A) modification, significantly broadened our understanding of RNA function and regulation. While interacti...
Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality [0.03%]
利用合成剂量致死性鉴定PLK1高表达癌症的治疗靶点
Chelsea E Cunningham,Frederick S Vizeacoumar,Yue Zhang et al.
Chelsea E Cunningham et al.
Chromosomal instability (CIN) drives tumor heterogeneity, complicating cancer therapy. Although Polo-like kinase 1 (PLK1) overexpression induces CIN, direct inhibition of PLK1 has shown limited clinical benefits. We therefore performed a ge...
Super RNA Pol II domains enhance minor ZGA through 3D interaction to ensure the integrity of major transcriptional waves in late-ZGA mammals [0.03%]
超型RNA聚合酶II调控区域通过三维互作增强次要ZGA以保障晚期ZGA哺乳动物主要转录波的完整性
Jingcheng Zhang,Hengkuan Li,Linmi Li et al.
Jingcheng Zhang et al.
Zygotic genome activation (ZGA) occurs at distinct stages across mammals, with mice initiating ZGA at the 2-cell stage and bovines and humans activating the process in the 4- to 8-cell stages. RNA polymerase II (RNA Pol II) gradually initia...