The dimmer switch in epigenetics: How DNA methylation encodes gene activity over time [0.03%]
表观遗传学中的调光开关：DNA甲基化如何随时间编码基因活性
Aleksandra Pękowska
Aleksandra Pękowska
Can individual cells retain a memory of past gene expression levels even after the stimulus has faded? In this issue of Cell Genomics, Domitilla Del Vecchio and colleagues describe an analog epigenetic memory system in which DNA methylation...
The gut's hidden arsenal: A genomics-guided atlas of class II bacteriocins [0.03%]
揭秘肠道隐藏的武器箱：基于基因组学导向的二类细菌素图谱研究
Tianang Leng,Cesar de la Fuente-Nunez
Tianang Leng
Unmodified class II bacteriocins promise precision antimicrobials that spare bystander microbes. Zhang and colleagues introduce IIBacFinder, a genomics-guided pipeline that detects precursor and context genes with a curated pHMM library, in...
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts [0.03%]
疾病相关染色质可及性QTLs在免疫细胞类型和背景中的影响
Zepeng Mu,Haley E Randolph,Raúl Aguirre-Gamboa et al.
Zepeng Mu et al.
Only one-third of immune-associated genome-wide association study (GWAS) loci colocalize with expression quantitative trait loci (eQTLs), leaving most mechanisms unresolved. To address this, we created a unified single-cell chromatin access...
Transcriptome-wide association studies at cell-state level using single-cell eQTL data [0.03%]
基于单细胞eQTL数据的细胞状态水平转录组关联分析
Guanghao Qi,Eardi Lila,Zhicheng Ji et al.
Guanghao Qi et al.
Transcriptome-wide association studies (TWASs) are widely used to prioritize genes for diseases. Current methods test gene-disease associations at the bulk tissue or cell-type-specific pseudobulk level, which do not account for the heteroge...
The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations [0.03%]
人类IGH等位基因的结构变异和编码多态性在不同人种中存在差异
Uddalok Jana,Oscar L Rodriguez,William Lees et al.
Uddalok Jana et al.
The human immunoglobulin heavy chain constant (IGHC) domain of antibodies (Abs) is responsible for effector functions critical to immunity. This domain is encoded by genes in the IGHC locus, where descriptions of genomic diversity remain in...
Structural and functional bases of F. rodentium Cas9 provide insights into CRISPR-Cas protein engineering [0.03%]
弗朗西丝菌属鼠菌株CRISPR-Cas系统蛋白工程的结构和功能基础研究
Mei Yang,Siqi Liu,Guanqiao Chen et al.
Mei Yang et al.
The Faecalibaculum rodentium (Fr) CRISPR-Cas9 system exhibits enhanced gene-editing precision and efficiency compared to SpCas9, with distinctive advantages in targeting the TATA box in eukaryotic promoters. However, the underlying molecula...
Predictive prioritization of enhancers associated with pancreatic disease risk [0.03%]
预测与胰腺疾病风险相关的增强子优先级划分
Li Wang,Songjoon Baek,Gauri Prasad et al.
Li Wang et al.
Genetic and epigenetic variation in enhancers is associated with disease susceptibility; however, linking enhancers to target genes and predicting enhancer dysfunction remain challenging. We mapped enhancer-promoter interactions in human pa...
Quanyi Zhao,Albert Pedroza,Disha Sharma et al.
Quanyi Zhao et al.
Arterial segments show differing disease propensities, yet mechanisms remain unknown. We compiled a transcriptomic and spatial atlas of healthy human arterial cells across multiple segments to understand these differences. Arteries demonstr...
Epigenome and interactome profiling uncovers principles of distal regulation in the barley genome [0.03%]
表观基因组和相互作用组分析揭示大麦基因组远距离调控的规律
Pavla Navratilova,Simon Pavlu,Zihao Zhu et al.
Pavla Navratilova et al.
Regulation of transcription initiation is the ground level of modulating gene expression during plant development. This process relies on interactions between transcription factors and cis-regulatory elements (CREs), which become promising ...
Co-mapping clonal and transcriptional heterogeneity in somatic evolution via GoT-Multi [0.03%]
通过GoT-Multi映射体细胞进化中的克隆和转录异质性
Minwoo Pak,Mirca S Saurty-Seerunghen,Kellie Wise et al.
Minwoo Pak et al.
Somatic evolution leads to clonal heterogeneity, which fuels cancer progression and therapy resistance. To decipher the consequences of clonal heterogeneity, we require a method that deconvolutes complex clonal architectures and their downs...