Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing [0.03%]
基于CRISPR的表观基因组编辑激活印记的Prader-Willi综合症基因座
Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi syndrome (PWS) results from loss of paternally ex...