Multi-omics characterization of silent and productive HPV integration in cervical cancer [0.03%]
宫颈癌中沉默和活跃HPV插入的多组学表征
Junpeng Fan,Yu Fu,Wenju Peng et al.
Junpeng Fan et al.
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a significant public health problem worldwide. HPV integration sites can be silent or actively transcribed, leading to the production of viral-host fusion t...
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts [0.03%]
全球生物样本库分析为在多样的队列中发展出多基因风险评分提供经验
Ying Wang,Shinichi Namba,Esteban Lopera et al.
Ying Wang et al.
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data from Global Biobank ...
The UCLA ATLAS Community Health Initiative: Promoting precision health research in a diverse biobank [0.03%]
加州大学洛杉矶分校的ATLAS社区健康计划：在多样化的生物样本库中促进精准医疗研究
Ruth Johnson,Yi Ding,Arjun Bhattacharya et al.
Ruth Johnson et al.
The UCLA ATLAS Community Health Initiative (ATLAS) has an initial target to recruit 150,000 participants from across the UCLA Health system with the goal of creating a genomic database to accelerate precision medicine efforts in California....
Shawn M Burgess
Shawn M Burgess
In this issue of Cell Genomics, McGarvey et al. characterize chromatin accessibility and gene regulation at single-cell resolution in the zebrafish embryo 24 h after fertilization, providing a valuable resource. Their findings add another i...
Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos [0.03%]
斑马鱼胚胎染色质架构的单细胞分辨率动力学确定细胞和调控状态
Alison C McGarvey,Wolfgang Kopp,Dubravka Vučićević et al.
Alison C McGarvey et al.
DNA accessibility of cis-regulatory elements (CREs) dictates transcriptional activity and drives cell differentiation during development. While many genes regulating embryonic development have been identified, the underlying CRE dynamics co...
Vincent Plagnol
Vincent Plagnol
In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). I...
Taiwan Biobank: A rich biomedical research database of the Taiwanese population [0.03%]
台湾生物样本库：台湾人群的丰富医学研究数据库
Yen-Chen Anne Feng,Chia-Yen Chen,Tzu-Ting Chen et al.
Yen-Chen Anne Feng et al.
The Taiwan Biobank (TWB) is an ongoing prospective study of >150,000 individuals aged 20-70 in Taiwan. A comprehensive list of phenotypes was collected for each consented participant at recruitment and follow-up visits through structured in...
A Nobel in evolution [0.03%]
诺贝尔奖花落进化论研究者
Laura M Zahn
Laura M Zahn
A home for the genome [0.03%]
基因组也有一个家了
Laura M Zahn
Laura M Zahn
Manel Esteller
Manel Esteller
Mouse models are widely used in biomedical sciences and in epigenetic studies, yet a simple way to interrogate the mouse DNA methylation was lacking. In this issue of Cell Genomics, Zhou et al.1 describe a mouse DNA methylation microarray t...