CSI-GEP: A GPU-based unsupervised machine learning approach for recovering gene expression programs in atlas-scale single-cell RNA-seq data [0.03%]
基于GPU的无监督机器学习方法CSI-GEP：在单细胞RNA测序图谱规模数据中恢复基因表达程序
Exploratory analysis of single-cell RNA sequencing (scRNA-seq) typically relies on hard clustering over two-dimensional projections like uniform manifold approximation and projection (UMAP). However, such methods can severely distort the da...
Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations [0.03%]
长程增强子控制的基因对调控因子扰动异常敏感
Cell-type-specific gene activation is regulated by enhancers, sometimes located at large genomic distances from target gene promoters. Whether distal enhancers require specific factors to orchestrate gene regulation remains unclear. Here, w...
Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing [0.03%]
基于CRISPR的表观基因组编辑激活印记的Prader-Willi综合症基因座
Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi syndrome (PWS) results from loss of paternally ex...