Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path [0.03%]
胚胎与偏见：从多样的初次转录印象到共同的发育路径
Guillaume Giraud Collet,Nicola Festuccia,Pablo Navarro
Guillaume Giraud Collet
Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain...
The fine art of chromatin folding: Revealing the path of DNA inside mitotic chromosomes [0.03%]
染色质折叠的精湛技艺：揭示有丝分裂中DNA的路径
Marina Vitoria Gomes,Christian H Haering
Marina Vitoria Gomes
How chromatin fibers fold into rod-shaped mitotic chromosomes has long been a central question in genome biology. Two new studies now reconstruct the path of DNA in human chromosomes at nanoscale resolution and reveal how loop-extruding mol...
Anthony M Gacita,Struan F A Grant
Anthony M Gacita
Many children presenting with type 1 diabetes have a family history of the disorder or another autoimmune disease. In this issue of Cell Genomics, Wang et al.1 use extensive clinical and genetic databases to identify the genetic factors con...
ESC models of autism with copy-number variations reveal cell-type-specific translational vulnerability [0.03%]
携带拷贝数变异的自闭症患者来源类器官模型揭示了特定类型细胞的蛋白合成异常
Jun Nomura,Amila Zuko,Keiko Kishimoto et al.
Jun Nomura et al.
Human genetics has identified numerous copy-number variations (CNVs) associated with autism spectrum disorders (ASDs). However, the lack of standardized biological resources impedes understanding of the cell-type-specific common features of...
CXCR4-LASP1-G9a-SNAIL axis drives NEPC transdifferentiation via induction of EMT and downregulation of REST [0.03%]
CXCR4-LASP1-G9a-SNAIL轴通过诱导EMT和REST下调驱动NEPC转分化
Liangliang Liu,Itzel Astiazarán Rascón,Dong Lin et al.
Liangliang Liu et al.
Phenotypic switching is an emerging driver of cancer treatment resistance, yet early signals regulating this process remain unclear. Here, using longitudinal single-cell RNA sequencing, we mapped differentiation trajectories in the LTL331 p...
Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis [0.03%]
人类遗传变异表明FCRL3是耶尔森氏鼠疫杆菌的淋巴细胞受体
Rachel M Keener,Sam Shi,Trisha Dalapati et al.
Rachel M Keener et al.
Yersinia pestis is the bacterium responsible for plague, one of the deadliest diseases in history. To discover human genetic determinants of Y. pestis infection, we utilized nearly 1,000 genetically diverse lymphoblastoid cell lines in a ce...
Extensive differential gene expression and regulation by sex in human skeletal muscle [0.03%]
人类骨骼肌中广泛存在性别差异基因表达及其调节机制
Sarah C Hanks,Abigail S Mauger,Arushi Varshney et al.
Sarah C Hanks et al.
The identification of sex-differential gene regulatory elements is essential for understanding sex-differential patterns of health and disease. We leveraged bulk and single-nucleus RNA sequencing (RNA-seq) and single-nucleus ATAC-seq data f...
SpaLinker identifies phenotype-associated spatial tumor microenvironment features by integrating bulk and spatial sequencing data [0.03%]
SpaLinker通过整合bulk和空间测序数据识别与表型相关的肿瘤微环境空间特征
Xiaojie Cheng,Chen Tang,Kejing Dong et al.
Xiaojie Cheng et al.
The emergence of spatial transcriptomics (ST) technology offers unprecedented opportunities to elucidate the complexity and heterogeneity of the tumor microenvironment (TME). However, quantitatively linking spatially resolved features with ...
Elena Fusari,Mariana Muzzopappa,Juliette Gracia et al.
Elena Fusari et al.
Aneuploidy is pervasive in early human embryos but robustly dampened during development. Later in life, aneuploidy correlates with pathological conditions, including cancer. Identification of the mechanisms underlying the elimination of ane...
Pisces: A multi-modal data augmentation approach for drug combination synergy prediction [0.03%]
用于药物组合协同预测的多模态数据增强方法 Pisces
Hanwen Xu,Jiacheng Lin,Addie Woicik et al.
Hanwen Xu et al.
Drug combination therapy is promising for cancer treatment by reducing resistance and improving efficacy. Machine learning approaches to predicting drug combinations require massive training data. Here, we propose Pisces, a novel machine le...