Moran N Cabili,Jonathan Lawson,Andrea Saltzman et al.
Moran N Cabili et al.
The current paradigm for data use oversight of biomedical datasets is onerous, extending the timescale and resources needed to obtain access for secondary analyses, thus hindering scientific discovery. For a researcher to utilize a controll...
Rosa Fregel
Rosa Fregel
In the sixth century, the Avar elites established themselves in the Carpathian Basin as evidenced today by the astounding archaeological sites with exquisite grave goods made of silver and gold. Recently reported in Cell, Gnecchi-Ruscone et...
Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma [0.03%]
原发性开角型青光眼的视网膜节细胞特异性遗传调控
Maciej Daniszewski,Anne Senabouth,Helena H Liang et al.
Maciej Daniszewski et al.
To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into reti...
Global priorities for large-scale biomarker-based prospective cohorts [0.03%]
基于生物标志物的大规模前瞻性队列的全球优先事项
Rory Collins,Mary K Balaconis,Søren Brunak et al.
Rory Collins et al.
The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health ou...
Jose Espejo Valle-Inclan,Nicolle J M Besselink,Ewart de Bruijn et al.
Jose Espejo Valle-Inclan et al.
Accurate detection of somatic structural variation (SV) in cancer genomes remains a challenging problem. This is in part due to the lack of high-quality, gold-standard datasets that enable the benchmarking of experimental approaches and bio...
Emilie M Wigdor,Daniel J Weiner,Jakob Grove et al.
Emilie M Wigdor et al.
Autism spectrum disorder (ASD) is diagnosed three to four times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common inherited ge...
Jose C Florez
Jose C Florez
Two diabetes-related papers are featured in this issue of Cell Genomics. Gardner et al.1 focus on type 2 diabetes through exome sequencing, and Benaglio et al.2 employ a functional genomics approach to advance understanding in type 1 diabet...
Expanding the genomic encyclopedia of Actinobacteria with 824 isolate reference genomes [0.03%]
通过824个分离株参考基因组扩展放线菌基因组百科全书
Rekha Seshadri,Simon Roux,Katharina J Huber et al.
Rekha Seshadri et al.
The phylum Actinobacteria includes important human pathogens like Mycobacterium tuberculosis and Corynebacterium diphtheriae and renowned producers of secondary metabolites of commercial interest, yet only a small part of its diversity is r...
Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity [0.03%]
多祖先哮喘元分析鉴定出新的关联并突显了提升统计功效和增加多样性的价值
Kristin Tsuo,Wei Zhou,Ying Wang et al.
Kristin Tsuo et al.
Asthma is a complex disease that varies widely in prevalence across populations. The extent to which genetic variation contributes to these disparities is unclear, as the genetics underlying asthma have been investigated primarily in popula...
Prokaryotic and viral genomes recovered from 787 Japanese gut metagenomes revealed microbial features linked to diets, populations, and diseases [0.03%]
从日本人的肠道元基因组中恢复出的原核和病毒基因组揭示了与饮食、人群以及疾病相关的微生物特征
Yoshihiko Tomofuji,Toshihiro Kishikawa,Yuichi Maeda et al.
Yoshihiko Tomofuji et al.
We reconstructed 19,084 prokaryotic and 31,395 viral genomes from 787 Japanese gut metagenomes as Japanese metagenome-assembled genomes (JMAG) and Japanese Virus Database (JVD), which are large microbial genome datasets for a single populat...