Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities [0.03%]
多功能长链非编码RNA图谱揭示非小细胞肺癌的弱点
Roberta Esposito,Taisia Polidori,Dominik F Meise et al.
Roberta Esposito et al.
Long noncoding RNAs (lncRNAs) are widely dysregulated in cancer, yet their functional roles in cancer hallmarks remain unclear. We employ pooled CRISPR deletion to perturb 831 lncRNAs detected in KRAS-mutant non-small cell lung cancer (NSCL...
Karen Echeverri
Karen Echeverri
The discovery of regeneration-specific enhancer elements has added an exciting player to the field of regeneration biology. In this issue of Cell Genomics, Jimenez et al.1 demonstrate the power of combining single-cell genomics with the gen...
Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes [0.03%]
英国生物银行394,841个外显子的千种表型的系统单变异和基因相关检验
Konrad J Karczewski,Matthew Solomonson,Katherine R Chao et al.
Konrad J Karczewski et al.
Genome-wide association studies have successfully discovered thousands of common variants associated with human diseases and traits, but the landscape of rare variations in human disease has not been explored at scale. Exome-sequencing stud...
Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution [0.03%]
同一细胞多种谱系测量的整合重构了肿瘤的平行演化过程
Lennart Kester,Buys de Barbanson,Anna Lyubimova et al.
Lennart Kester et al.
Organoid evolution models complemented with integrated single-cell sequencing technology provide a powerful platform to characterize intra-tumor heterogeneity (ITH) and tumor evolution. Here, we conduct a parallel evolution experiment to mi...
A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer [0.03%]
一种基于类器官的大规模筛选平台用于推进胰腺癌药物再定位研究
Sara Mainardi,Rene Bernards
Sara Mainardi
Hirt et al.1 report an automated, high-throughput drug screening platform for organoid cultures to enable repurposing of previously approved drugs for pancreatic cancers harboring specific genetic alterations. The pancreatic cancer organoid...
Peter J Campbell
Peter J Campbell
Multiple somatic mutations drive cancer cell transformation, but the sequence of events is poorly understood. In this issue of Cell Genomics, Kester et al. combine organoid technology, prospective barcode labeling, and single-cell sequencin...
Voices of GA4GH members: Collaborating in technology and policy development [0.03%]
GA4GH成员之声：在技术和政策开发方面开展合作
The Global Alliance for Genomics and Health (GA4GH) is organized around eight Work Streams, where members develop technology standards and policy frameworks to enable the responsible sharing of human genomic and health-related data. These a...
Chris Lunt,Joshua C Denny
Chris Lunt
In this issue of Cell Genomics, GA4GH reports key efforts to help share data across enclaves, including a framework for responsible data sharing, a data use ontology, and approaches for data use oversight. While there remains work in establ...
Orli G Bahcall
Orli G Bahcall
CanDIG: Federated network across Canada for multi-omic and health data discovery and analysis [0.03%]
.CanDIG：加拿大跨机构的多组学和健康数据发现与分析联盟
L Jonathan Dursi,Zoltan Bozoky,Richard de Borja et al.
L Jonathan Dursi et al.
We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which enables federated querying and analysis of human genomics and linked biomedical data. CanDIG leverages the standards and frameworks of the Global Allia...