Stop codon context modulates NMD efficiency through translation termination kinetics [0.03%]
终止密码子的背景调控通过翻译终止动力学调控无义介导的mRNA降解效率
Dasa Longman,Laura Monaghan,Javier F Cáceres
Dasa Longman
Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study by Kolakada et al.1 demonstrates that glycine residues preceding stop codons create an extended translation...
Qing Yang,Zhi-Yang Hou,Linxia Li et al.
Qing Yang et al.
The soybean is a critical source of vegetable protein, but its proteome remains undercharacterized. Here, we quantify 12,855 proteins across 14 soybean organs using 4D data-independent acquisition mass spectrometry (4D-DIA-MS), creating the...
Coordinated regulation by lncRNAs results in tight lncRNA-target couplings [0.03%]
长非编码RNA的协调调节导致紧密的长非编码RNA-目标结合体
Hua-Sheng Chiu,Sonal Somvanshi,Chung-Te Chang et al.
Hua-Sheng Chiu et al.
The determination of long non-coding RNA (lncRNA) function is a major challenge in RNA biology with applications to basic, translational, and medical research. We developed BigHorn to computationally infer lncRNA-DNA interactions that media...
Benchmarking of T cell receptor-epitope predictors with ePytope-TCR [0.03%]
基于ePytope-TCR对T细胞受体表位预测工具的评测
Felix Drost,Anna Chernysheva,Mahmoud Albahah et al.
Felix Drost et al.
Understanding the recognition of disease-derived epitopes through T cell receptors (TCRs) has the potential to serve as a stepping stone for the development of efficient immunotherapies and vaccines. While a plethora of sequence-based predi...
Structural diversity and evolutionary constraints of oxidative phosphorylation [0.03%]
氧化磷酸化的结构多样性及进化约束
José Luis Cabrera-Alarcón,Marina Rosa-Moreno,Lucía Sánchez-García et al.
José Luis Cabrera-Alarcón et al.
The oxidative phosphorylation (OxPhos) system is central to metabolism. The more than 90 structural subunits are encoded by different chromosome categories (autosomal, X, and mtDNA). The system is envisioned as an invariant structure betwee...
Scalable screening of ternary-code DNA methylation dynamics associated with human traits [0.03%]
大规模筛选与人类性状相关的三元码DNA甲基化动态效应
David C Goldberg,Cameron Cloud,Sol Moe Lee et al.
David C Goldberg et al.
Epigenome-wide association studies (EWASs) are transforming our understanding of the interplay between epigenetics and complex human traits. We introduce the methylation screening array (MSA) to enable scalable and quantitative screening of...
Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal [0.03%]
蚊子进餐后的肠道和脂肪体的单细胞转录景观
Thomas Vial,Hélène Lopez-Maestre,Elodie Couderc et al.
Thomas Vial et al.
Aedes aegypti mosquitoes transmit arboviruses that pose a growing global health threat. After a bloodmeal, mosquitoes experience complex physiological changes orchestrated by the midgut and fat body, beginning with digestion and culminating...
Evolutionarily recent transcription factors partake in human cell cycle regulation [0.03%]
新颖转录因子参与人体细胞周期调控
Cyril Pulver,Romain Forey,Alex R Lederer et al.
Cyril Pulver et al.
The cell cycle is a fundamental process in eukaryotic biology and is accordingly controlled by a highly conserved core signaling cascade. However, whether recently evolved proteins also influence this process is unclear. Here, we systematic...
A rare, evolutionarily conserved venom protein benefits endoparasitism across parasitoids [0.03%]
一种罕见的进化上保守的毒液蛋白有利于寄生oids跨内 Parasitism
Zhi Dong,Yueqi Lu,Gangqi Fang et al.
Zhi Dong et al.
Although many venom proteins and other parasitic effectors have been identified in various specific systems of parasitoids, key elements that contribute to parasitic success across a broad range of taxa remain largely unexplored. Here, we f...
Emily Stephenson,Erin Macdonald-Dunlop,Lisa M Dratva et al.
Emily Stephenson et al.
Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. We performed longitudinal single-cell immune profiling of ESKD patients with COVID-19. Transcriptome, surface proteome, and immunoreceptor sequencing data we...