Christophe Chapard,Nathalie Bastié,Axel Cournac et al.
Christophe Chapard et al.
The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. Structural maintenance of chromosome (SMC) complexes are essential instruments of chromosome...
Genomic insights into the demographic history and local adaptation of wild boars across Eurasia [0.03%]
基因组学见解：欧亚野猪的 demographic 历史和本地适应性
Zishuai Wang,Zixin Li,Tao Huang et al.
Zishuai Wang et al.
Wild boars exhibit genetic and phenotypic diversity shaped by migrations and local adaptations. Their expansion across Eurasia, especially in Central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wild...
Konstantinos C Makris,Andrea Baccarelli,Edwin K Silverman et al.
Konstantinos C Makris et al.
Because genetics and the environment interact to drive gene expression, we propose that exposomics must now be incorporated into the multi-omics paradigm to complete the overall biological pathway. Exposomics' groundbreaking tools and life-...
Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues [0.03%]
多态性对运动和饮食控制减肥反应的基因表达及剪接的影响研究-来自人类骨骼肌组织的证据
Wenjing Wang,Wei Lin Liew,Shiqi Huang et al.
Wenjing Wang et al.
Weight loss through exercise and diet reduces the risk of type 2 diabetes, but the genetic regulation of gene expression and splicing in response to weight loss remains unclear in humans. We collected clinical data and skeletal muscle biops...
Oncogenic roles of young human de novo genes and their potential as neoantigens in cancer immunotherapy [0.03%]
年轻的人类从头起源基因的致癌作用及其作为肿瘤免疫治疗neoantigen的潜力
Chunfu Xiao,Xiaoge Liu,Peiyu Liu et al.
Chunfu Xiao et al.
Young human de novo genes, recently emerging from non-coding regions, are expected to contribute to human-specific traits and diseases. However, systematic explorations of this connection have been lacking. Here, we report 37 recently origi...
OmicsTweezer: A distribution-independent cell deconvolution model for multi-omics Data [0.03%]
OmicsTweezer：一种用于多组学数据的独立分布细胞去卷积模型
Xinxing Yang,Faming Zhao,Tao Ren et al.
Xinxing Yang et al.
Cell deconvolution estimates cell type proportions from bulk omics data, enabling insights into tissue microenvironments and disease. However, practical applications are often hindered by batch effects between bulk data and referenced singl...
The CST complex mediates a post-resection non-homologous end joining repair pathway and promotes local deletions in Saccharomyces cerevisiae [0.03%]
CST复合体介导了不依赖重组的末端连接修复途径并在酿酒酵母中促进局部缺失产生
Oana Ilioaia,Liébaut Dudragne,Clémentine Brocas et al.
Oana Ilioaia et al.
The repair of a DNA double-strand break (DSB) by non-homologous end joining (NHEJ) generally leaves an intact or minimally modified sequence. Resection exposes single-stranded DNA and directs repair toward homology-dependent pathways and aw...
The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity [0.03%]
外泌体转录组提供了与肥胖相关疾病易感性相关的组织特异性功能基因组注释
Emeli Chatterjee,Michael J Betti,Quanhu Sheng et al.
Emeli Chatterjee et al.
We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity (277 unique genes; false discovery rate < 10%). Since circulating EVs may have broad o...
Exploring genetic adaptation and microbial dynamics in engineered anaerobic ecosystems via strain-level metagenomics [0.03%]
基于菌株水平元基因组学的工程厌氧生态系统中的基因适应及微生物动态研究
Gabriele Ghiotto,Aikaterini Xirostylidou,Maria Gaspari et al.
Gabriele Ghiotto et al.
Genetic heterogeneity exists within all microbial populations, with sympatric cells of the same species often exhibiting single-nucleotide variations that influence phenotypic traits, including metabolic efficiency. However, the evolutionar...
Peripheral chromatin remodeling at the center of zygotic genome activation [0.03%]
胚胎基因组激活中心的外围染色质重塑作用
Laure de Chancel,Jean-Léon Maître
Laure de Chancel
Pal and colleagues1 investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable...