CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway [0.03%]
CXCR4通过JAK2/STAT3信号通路调控TOX诱导的CD8⁺ T细胞耗竭表型
Canhui Cao,Miaochun Xu,Ye Wei et al.
Canhui Cao et al.
Evidence from clinical trials suggests that CXCR4 antagonists enhance immunotherapy effectiveness in several cancers. However, the specific mechanisms through which CXCR4 contributes to immune cell phenotypes are not fully understood. Here,...
Identifying compound-protein interactions with knowledge graph embedding of perturbation transcriptomics [0.03%]
基于干扰转录组学知识图嵌入的化合物-蛋白质相互作用识别
Shengkun Ni,Xiangtai Kong,Yingying Zhang et al.
Shengkun Ni et al.
The emergence of perturbation transcriptomics provides a new perspective for drug discovery, but existing analysis methods suffer from inadequate performance and limited applicability. In this work, we present PertKGE, a method designed to ...
Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response [0.03%]
转录本异构体的功能和动态谱分析揭示了干扰素反应中可变剪接的重要作用
Mahoko Takahashi Ueda,Jun Inamo,Fuyuki Miya et al.
Mahoko Takahashi Ueda et al.
Type I interferon (IFN-I) plays an important role in the innate immune response through inducing IFN-I-stimulated genes (ISGs). However, how alternative splicing (AS) events, especially over time, affect their function remains poorly unders...
Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome [0.03%]
母体基因组影响人类乳汁的组成及其对婴儿肠道菌群的影响
Kelsey E Johnson,Timothy Heisel,Mattea Allert et al.
Kelsey E Johnson et al.
Human milk is a complex mix of nutritional and bioactive components that provide complete nourishment for the infant. However, we lack a systematic knowledge of the factors shaping milk composition and how milk variation influences infant h...
Hui Wang,Mingqi Xie
Hui Wang
Drug resistance is a major hurdle prohibiting effective treatment of many diseases, including cancer. Using model-guided designs, Leighow et al.1 engineered a dual-switch selection gene drive system custom designed to combat drug-resistant ...
Paxton Kostos,Anna Galligos,Jennifer L Gerton
Paxton Kostos
In this issue of Cell Genomics, Rothschild et al.1 reveal how ribosomal RNA diversity impacts ribosome structure and its implications for health and disease. Their innovative methodologies uncover distinct ribosome subtypes with significant...
Missing regulatory effects and viral triggers explored for childhood-onset asthma [0.03%]
儿童期发病哮喘的缺失性调节效应和病毒触发因素研究
Hai Fang
Hai Fang
Missing regulatory effects of asthma genetic risks might be hidden within specific cell states. In this issue of Cell Genomics, Djeddi et al.1 uncover how airway epithelial cells, when activated by rhinovirus, influence genetic susceptibili...
Long genetic and social isolation in Neanderthals before their extinction [0.03%]
灭绝前尼安德特人长期的基因和社交隔绝性
Ludovic Slimak,Tharsika Vimala,Andaine Seguin-Orlando et al.
Ludovic Slimak et al.
Neanderthal genomes have been recovered from sites across Eurasia, painting an increasingly complex picture of their populations' structure that mostly indicates that late European Neanderthals belonged to a single metapopulation with no si...
Pooled endogenous protein tagging and recruitment for systematic profiling of protein function [0.03%]
蛋白质汇集内源性标记和募集技术用于系统分析蛋白质功能
Yevgeniy V Serebrenik,Deepak Mani,Timothé Maujean et al.
Yevgeniy V Serebrenik et al.
The emerging field of induced proximity therapeutics, which involves designing molecules to bring together an effector and target protein-typically to induce target degradation-is rapidly advancing. However, its progress is constrained by t...
An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing [0.03%]
基于长读长单细胞测序的结直肠癌转录组图谱
Zhongxiao Li,Bin Zhang,Jia Jia Chan et al.
Zhongxiao Li et al.
Colorectal cancer (CRC) ranks as the second leading cause of cancer deaths globally. In recent years, short-read single-cell RNA sequencing (scRNA-seq) has been instrumental in deciphering tumor heterogeneities. However, these studies only ...