Double or nothing: Ancient duplications in the amylase locus drove human adaptation [0.03%]
人类淀粉酶基因适应性扩增的遗传痕迹
Shahar Silverman,Diyendo Massilani
Shahar Silverman
Salivary and pancreatic amylase are encoded by AMY1 and AMY2, respectively, which are located within a single genomic locus that has undergone substantial structural variation, resulting in varying gene copy numbers across species. Using op...
Atlas-scale single-cell DNA methylation profiling with sciMETv3 [0.03%]
基于sciMETv3的大规模单细胞DNA甲基化谱图绘制技术
Ruth V Nichols,Lauren E Rylaarsdam,Brendan L O&#x;Connell et al.
Ruth V Nichols et al.
Single-cell methods to assess DNA methylation have not achieved the same level of cell throughput per experiment compared to other modalities, with large-scale datasets requiring extensive automation, time, and other resources. Here, we des...
CRISPR-Cas spacer acquisition is a rare event in human gut microbiome [0.03%]
CRISPR-Casspacer获取在人类肠道微生物组中是罕见事件
An-Ni Zhang,Jeffry M Gaston,Pablo Cárdenas et al.
An-Ni Zhang et al.
Host-parasite relationships drive the evolution of both parties. In microbe-phage dynamics, CRISPR functions as an adaptive defense mechanism, updating immunity via spacer acquisition. Here, we investigated these interactions within the hum...
Manuel Corpas,Mkpouto Pius,Marie Poburennaya et al.
Manuel Corpas et al.
Achieving diverse representation in biomedical data is critical for healthcare equity. Failure to do so perpetuates health disparities and exacerbates biases that may harm patients with underrepresented ancestral backgrounds. We present a q...
AI techniques have facilitated the understanding of epitranscriptome distribution [0.03%]
人工智能技术促进了表转录组修饰分布的理解
Daiyun Huang,Jia Meng,Kunqi Chen
Daiyun Huang
N6-methyladenosine (m6A), the most prevalent internal mRNA modification in higher eukaryotes, plays diverse roles in cellular regulation. By incorporating both sequence- and genome-derived features, Fan et al.1 designed a novel Transformer-...
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes [0.03%]
基因剂量对认知能力的影响：大脑和非大脑过程的功能性关联研究
Guillaume Huguet,Thomas Renne,Cécile Poulain et al.
Guillaume Huguet et al.
Copy-number variants (CNVs) that increase the risk for neurodevelopmental disorders also affect cognitive ability. However, such CNVs remain challenging to study due to their scarcity, limiting our understanding of gene-dosage-sensitive bio...
scTrends: A living review of commercial single-cell and spatial 'omic technologies [0.03%]
scTrends：商业单细胞和空间组学技术的living review
Joachim De Jonghe,James W Opzoomer,Amaia Vilas-Zornoza et al.
Joachim De Jonghe et al.
Understanding the rapidly evolving landscape of single-cell and spatial omic technologies is crucial for advancing biomedical research and drug development. We provide a living review of both mature and emerging commercial platforms, highli...
Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [0.03%]
单细胞表观转录组的统计建模及其在RNA甲基化轨迹和调控推断中的应用
Haozhe Wang,Yue Wang,Jingxian Zhou et al.
Haozhe Wang et al.
As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms. Recent advances in single-cell technology have enabled simultaneou...
Characterizing the genetic architecture of drug response using gene-context interaction methods [0.03%]
利用基因-环境互作方法研究药物反应的遗传结构
Michal Sadowski,Mike Thompson,Joel Mefford et al.
Michal Sadowski et al.
Identifying factors that affect treatment response is a central objective of clinical research, yet the role of common genetic variation remains largely unknown. Here, we develop a framework to study the genetic architecture of response to ...
Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning [0.03%]
成年单核神经元转录组揭示了胰岛素信号突变体的行为和学习调节因子
Jonathan St Ange,Yifei Weng,Rachel Kaletsky et al.
Jonathan St Ange et al.
Gene expression in individual neurons can change during development to adulthood and can have large effects on behavior. Additionally, the insulin/insulin-like signaling (IIS) pathway regulates many of the adult functions of Caenorhabditis ...