Urine cf-nucleosomes: A non-invasive window into human physiology and disease [0.03%]
尿液cf-核小体：非侵入式观察人体生理和疾病的新窗口
Matan Lotem,Israa Sharkia,Batia Azria et al.
Matan Lotem et al.
Urine contains fragments of cell-free DNA (cfDNA) that offer molecular insights into processes within the urinary system and the body. It remains unclear whether these fragments exist as chromatin and retain chromatin modifications from the...
Take the bull by the horns: A computational framework to predict lncRNA function [0.03%]
抓住牛角：预测长链非编码 RNA (lncRNA) 功能的计算框架
Amit Felach,Assaf C Bester
Amit Felach
In this issue of Cell Genomics, Chiu et al.1 present a new framework, "BigHorn," to predict lncRNA chromatin interactions and show that it can be used to predict lncRNA function. Felach and Bester discuss the findings in this preview articl...
David Gfeller
David Gfeller
Accurate TCR-epitope interaction predictions have the potential to unlock the use of TCR repertoires for diagnostics, TCR discovery, and cross-reactivity predictions. In this issue of Cell Genomics, Drost et al.1 developed a streamlined fra...
Ander Díaz-Navarro,Xindi Zhang,Wei Jiao et al.
Ander Díaz-Navarro et al.
Understanding how genomic alterations drive cancer is key to advancing precision oncology. To detect these alterations, accurate algorithms are used; however, due to privacy concerns, few deeply sequenced cancer genomes can be shared, limit...
The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance [0.03%]
脓毒症中循环细胞游离DNA景观主要由肝脏清除功能障碍所主导
Kiki Cano-Gamez,Patrick Maclean,Masato Inoue et al.
Kiki Cano-Gamez et al.
Circulating cell-free DNA (cfDNA) is a promising molecular biomarker, but its role in severe infection is unclear. Here, we profile cfDNA from sepsis patients and controls, demonstrating a 41-fold increase during disease. Methylation-based ...
Christophe Chapard,Nathalie Bastié,Axel Cournac et al.
Christophe Chapard et al.
The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. Structural maintenance of chromosome (SMC) complexes are essential instruments of chromosome...
Genomic insights into the demographic history and local adaptation of wild boars across Eurasia [0.03%]
基因组学见解：欧亚野猪的 demographic 历史和本地适应性
Zishuai Wang,Zixin Li,Tao Huang et al.
Zishuai Wang et al.
Wild boars exhibit genetic and phenotypic diversity shaped by migrations and local adaptations. Their expansion across Eurasia, especially in Central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wild...
Konstantinos C Makris,Andrea Baccarelli,Edwin K Silverman et al.
Konstantinos C Makris et al.
Because genetics and the environment interact to drive gene expression, we propose that exposomics must now be incorporated into the multi-omics paradigm to complete the overall biological pathway. Exposomics' groundbreaking tools and life-...
Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues [0.03%]
多态性对运动和饮食控制减肥反应的基因表达及剪接的影响研究-来自人类骨骼肌组织的证据
Wenjing Wang,Wei Lin Liew,Shiqi Huang et al.
Wenjing Wang et al.
Weight loss through exercise and diet reduces the risk of type 2 diabetes, but the genetic regulation of gene expression and splicing in response to weight loss remains unclear in humans. We collected clinical data and skeletal muscle biops...
Oncogenic roles of young human de novo genes and their potential as neoantigens in cancer immunotherapy [0.03%]
年轻的人类从头起源基因的致癌作用及其作为肿瘤免疫治疗neoantigen的潜力
Chunfu Xiao,Xiaoge Liu,Peiyu Liu et al.
Chunfu Xiao et al.
Young human de novo genes, recently emerging from non-coding regions, are expected to contribute to human-specific traits and diseases. However, systematic explorations of this connection have been lacking. Here, we report 37 recently origi...